{"orpha":90081,"name":"AIDS wasting syndrome","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare condition associated with acquired immunodeficiency syndrome (AIDS) and characterized by unwanted weight loss (involving both fat and muscle) of more than ten percent of body weight, with either diarrhea or weakness and fever which have lasted at least 30 days and are not related to an infection.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90081/","orphanet_url":"https://www.orpha.net/en/disease/detail/90081","names":{"fr":{"name":"Etat de cachexie lié au sida","definition":"Maladie rare associée au syndrome d'immunodéficience acquise (SIDA) caractérisée par une perte involontaire de poids de plus de dix pour cent du poids corporel (concernant aussi bien la masse graisseuse que la masse musculaire), accompagnée soit de diarrhée, soit de faiblesse et de fièvre, persistant au moins 30 jours en l'absence de toute infection."},"de":{"name":"Wasting-Syndrom bei AIDS","synonyms":["HIV-Auszehrungssyndrom"],"definition":"Ein seltener Zustand, der mit dem erworbenen Immundefektsyndrom (AIDS) in Verbindung gebracht wird und durch einen unerwünschten Gewichtsverlust (sowohl bei Fett als auch bei Muskeln) von mehr als zehn Prozent des Körpergewichts gekennzeichnet ist, der entweder mit Durchfall oder Schwäche und Fieber einhergeht und seit mindestens 30 Tagen anhält und nicht auf eine Infektion zurückzuführen ist."},"es":{"name":"Síndrome de desgaste asociado al SIDA","definition":"Es un trastorno poco frecuente asociado al síndrome de inmunodeficiencia adquirida (SIDA) caracterizado por una pérdida de peso no deseada (que afecta tanto al tejido graso como muscular) de más del diez por ciento del peso corporal, con diarrea o debilidad y fiebre durante al menos 30 días y no asociados a infección."},"it":{"name":"Sindrome da deperimento da AIDS"},"nl":{"name":"AIDS-cachexiesyndroom","definition":"Een zeldzame aandoening geassocieerd met verworven immuundeficiëntiesyndroom (AIDS), gekenmerkt door ongewenst gewichtsverlies (met betrokkenheid van zowel vet als spier) van meer dan tien procent van het lichaamsgewicht, met ofwel diarree ofwel zwakte en koorts die minstens 30 dagen aanhouden en die niet gerelateerd zijn aan infectie."},"pt":{"name":"Síndrome de caquexia associada à SIDA","definition":"Condição rara associada à síndrome da imunodeficiência adquirida (AIDS) e caracterizada por perda de peso indesejada (envolvendo gordura e músculos) acima de dez por cento do peso corporal, com diarreia ou fraqueza e febre que duram pelo menos 30 dias e não estando relacionado com uma infeção."},"pl":{"name":"Zespół wyniszczenia wywołany AIDS","definition":"Rzadko występujący stan kojarzony z zespołem nabytego niedoboru odporności (AIDS), charakteryzujący się niezamierzoną utratą masy ciała (zarówno tkanki tłuszczowej, jak i mięśni) o więcej niż dziesięć procent masy ciała, której towarzyszy biegunka lub osłabienie i gorączka, które trwają co najmniej 30 dni i nie są związane z infekcją."},"cs":{"name":"AIDS syndrom chřadnutí"},"uk":{"name":"Синдром виснаження при СНІДі","definition":"A rare condition associated with acquired immunodeficiency syndrome (AIDS) and characterized by unwanted weight loss (involving both fat and muscle) of more than ten percent of body weight, with either diarrhea or weakness and fever which have lasted at least 30 days and are not related to an infection."},"zh":{"name":"艾滋病消耗综合征"},"tr":{"name":"AIDS tükenmişlik sendromu"}},"xrefs":[{"source":"ICD-10","code":"B22.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C62.3Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"956141777"},{"source":"MONDO","code":"0005797","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"5797","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D019247","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0343755","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10050309","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98004,"name":"Rare immune disease"},"parents":[{"orpha":310050,"name":"Rare acquired immunodeficiency","classifications":[195]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":20.0,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-25","source":"9834931[PMID]","terms":[{"hpo":"HP:0500012","label":"Abnormal gonadotropin-releasing hormone concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004326","label":"Cachexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002024","label":"Malabsorption","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004395","label":"Malnutrition","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003202","label":"Skeletal muscle atrophy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null}]}}