{"orpha":90065,"name":"Acquired aneurysmal subarachnoid hemorrhage","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, life threatening rare neurologic disease characterized by a sudden rupture of an intracranial aneurysm into the subarachnoid space. It usually presents with a sudden, severe, excruciating headache accompanied by nausea, vomiting and syncope. Other features may include focal neurological signs, third and sixth nerve palsies, seizures and cardiac failure. Early complications include rebleeding, hydrocephalus, and seizures.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90065/","orphanet_url":"https://www.orpha.net/en/disease/detail/90065","names":{"fr":{"name":"Hémorragie subarachnoïdienne par rupture d'anévrisme intracrânien, forme acquise","definition":"Maladie neurologique rare, mettant en jeu le pronostic vital, caractérisée par la rupture soudaine d'un anévrisme intracrânien dans l'espace sous-arachnoïdien. Elle se manifeste généralement par des maux de tête soudains, violents et lancinants, accompagnés de nausées, de vomissements et de syncopes. D'autres caractéristiques peuvent inclure des signes neurologiques focaux, des paralysies des 3 <sup>e</sup> et 6<sup>e</sup> nerfs, des crises convulsives et une insuffisance cardiaque. Parmi les complications immédiates figurent les saignements, l'hydrocéphalie et les crises convulsives."},"de":{"name":"Aneurysmatische Subarachnoidalblutung, erworbene","definition":"Eine lebensbedrohliche seltene neurologische Erkrankung, die durch eine plötzliche Ruptur eines intrakraniellen Aneurysmas in den Subarachnoidalraum gekennzeichnet ist. Sie präsentiert sich in der Regel mit einem plötzlichen, starken, quälenden Kopfschmerz, begleitet von Übelkeit, Erbrechen und Synkope. Weitere Merkmale können fokale neurologische Zeichen, Lähmungen des dritten und sechsten Nervs, Krampfanfälle und Herzversagen sein. Zu den frühen Komplikationen gehören Nachblutungen, Hydrozephalus und Krampfanfälle."},"es":{"name":"Hemorragia subaracnoidea aneurismática adquirida","definition":"Es una enfermedad neurológica poco frecuente, grave y potencialmente mortal, caracterizada por la ruptura espontánea de un aneurisma intracraneal en el espacio subaracnoideo. Por lo general, se presenta con una cefalea súbita muy intensa acompañada de náuseas, vómitos y síncope. Otros hallazgos pueden incluir signos neurológicos focales, parálisis del tercer y sexto pares craneales, convulsiones e insuficiencia cardíaca. Las complicaciones más inmediatas incluyen resangrado, hidrocefalia y convulsiones."},"it":{"name":"Emorragia subaracnoidea aneurismatica acquisita","definition":"L'emorragia subaracnoidea aneurismatica acquisita è una malattia neurologica rara grave e potenzialmente letale, caratterizzata dall'improvvisa rottura di un aneurisma intracranico nello spazio subaracnoideo. Di solito si manifesta con una cefalea improvvisa, grave e lancinante, associata a nausea, vomito e sincope. Possono associarsi segni neurologici focali, paralisi del terzo e del sesto nervo, crisi epilettiche e insufficienza cardiaca. Le complicanze immediate comprendono le nuove emorragie, l'idrocefalo e le crisi epilettiche."},"nl":{"name":"Verworven aneurysmale subarachnoïdale hemorragie","definition":"Een zeldzame, levensbedreigende, neurologische ziekte, gekarakteriseerd door plots scheuren van een intracranieel aneurysma in de subarachnoïdale ruimte. De ziekte manifesteert zich meestal met een plotse, ernstige, ondraaglijke hoofdpijn, samen met misselijkheid, braken en syncope. Andere mogelijke kenmerken zijn onder meer focale neurologische tekenen, derde en zesde zenuwverlammingen, insulten en hartfalen. Vroege complicaties zijn onder meer recidiefbloeding, hydrocefalie, en insulten."},"pt":{"name":"Hemorragia subaracnóidea aneurismática"},"pl":{"name":"Nabyty krwotok podpajęczynówkowy z pkniętego tętniaka"},"cs":{"name":"Získané subarachnoideální krvácení z aneuryzmatu"},"uk":{"name":"Набутий аневризматичний субарахноїдальний крововилив","definition":"A rare, life threatening rare neurologic disease characterized by a sudden rupture of an intracranial aneurysm into the subarachnoid space. It usually presents with a sudden, severe, excruciating headache accompanied by nausea, vomiting and syncope. Other features may include focal neurological signs, third and sixth nerve palsies, seizures and cardiac failure. Early complications include rebleeding, hydrocephalus, and seizures."},"zh":{"name":"获得性动脉瘤蛛网膜下腔出血"},"tr":{"name":"Edinsel anevrizmal subaraknoid kanama"}},"xrefs":[{"source":"ICD-10","code":"I60.9","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"8B01.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"958976948"},{"source":"MONDO","code":"0019543","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0338572","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":71281,"name":"Rare central nervous system and retinal vascular disease","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-13","source":"30535853[PMID]_24670311[PMID]_29623945[PMID]_27316915[PMID]_31051460[PMID]_30366144[PMID]","terms":[{"hpo":"HP:0009145","label":"Abnormal cerebral artery morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001342","label":"Cerebral hemorrhage","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100543","label":"Cognitive impairment","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001133","label":"Constriction of peripheral visual field","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002354","label":"Memory impairment","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012250","label":"ST segment depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025637","label":"Vasospasm","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030955","label":"Alcoholism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002637","label":"Cerebral ischemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000238","label":"Hydrocephalus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003124","label":"Hypercholesterolemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003074","label":"Hyperglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031885","label":"Hyperglycorrhachia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000821","label":"Hypothyroidism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031058","label":"Impairment of activities of daily living","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002490","label":"Increased CSF lactate","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002140","label":"Ischemic stroke","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001712","label":"Left ventricular hypertrophy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001658","label":"Myocardial infarction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002344","label":"Progressive neurologic deterioration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005184","label":"Prolonged QTc interval","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001279","label":"Syncope","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000505","label":"Visual impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040075","label":"Hypopituitarism","frequency":"Very rare (<4-1%)","criteria":null}]}}