{"orpha":90036,"name":"Mixed-type autoimmune hemolytic anemia","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Mixed AIHA"],"definition":"Mixed autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA) defined by the presence of both warm and cold autoantibodies, which have a deleterious effect on red blood cells at either body temperature or at lower temperatures.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90036/","orphanet_url":"https://www.orpha.net/en/disease/detail/90036","names":{"fr":{"name":"Anémie hémolytique auto-immune mixte","synonyms":["AIHA mixte"],"definition":"L'anémie hémolytique auto-immune mixte est une forme d'anémie hémolytique auto-immune (AHAI) définie par la présence conjointe d'auto-anticorps chauds et froids, délétères pour les hématies tant à température corporelle qu'à plus basses températures."},"de":{"name":"Anämie, autoimmun-hämolytische, gemischter Typ","definition":"Die Gemischte Autoimmun-hämolytische Anämie, eine Form der Autoimmun-hämolytischen Anämie (AIHA; s. dort), ist definiert durch das gleichzeitige Vorhandensein von Wärme- und Kälte-Autoantikörpern, die ihre deletären Auswirkungen auf die Erythrozyten sowohl bei Körpertemperatur als auch bei niedrigeren Temperaturen entfalten."},"es":{"name":"Anemia hemolítica autoinmune tipo mixto","synonyms":["AHAI tipo mixto","AIHA tipo mixto"],"definition":"La anemia hemolítica autoinmune (AHAI) tipo mixto o bifásica es un tipo de anemia hemolítica autoinmune (AIHA; véase este término) caracterizada por la presencia de autoanticuerpos (AAC) llamados bifásicos porque su acción nociva sobre los eritrocitos se ejerce tanto a temperatura corporal como por debajo de ella."},"it":{"name":"Anemia emolitica autoimmune, tipo misto","synonyms":["AIHA mista"]},"nl":{"name":"Auto-immune hemolytische anemie, gemengd type","synonyms":["Gemengde AIHA"],"definition":"Gemengde auto-immune hemolytische anemie is een type van auto-immune hemolytische anemie (AIHA), gekenmerkt door de aanwezigheid van zowel warme als koude auto-antilichamen, die een schadelijk effect hebben op rode bloedcellen bij lichaamstemperatuur en bij lagere temperaturen."},"pt":{"name":"Anemia hemolítica autoimune, tipo misto","definition":"A anemia hemolítica auto-imune mista é um tipo de anemia hemolítica autoimune (AIHA, ver este termo) definida pela presença de auto-anticorpos frios e quentes, que têm um efeito deletério sobre os glóbulos vermelhos à temperatura corporal ou a temperaturas mais baixas."},"pl":{"name":"Niedokrwistość autoimmunohemolityczna typu mieszanego","synonyms":["AIHA mieszana"]},"cs":{"name":"Autoimunitní hemolytická anémie smíšeného typu","synonyms":["Smíšená AIHA"]},"uk":{"name":"Аутоімунна гемолітична анемія змішаного типу","synonyms":["Змішаний АМСЗ"],"definition":"Mixed autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA; see this term) defined by the presence of both warm and cold autoantibodies, which have a deleterious effect on red blood cells at either body temperature or at lower temperatures."},"zh":{"name":"混合型自身免疫性溶血性贫血","synonyms":["混合型AIHA"]},"tr":{"name":"Karma tipte otoimmün hemolitik anemi","synonyms":["Karma AIHA"]}},"xrefs":[{"source":"ICD-10","code":"D59.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"3A20.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1878239449"},{"source":"MONDO","code":"0019534","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4305257","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":98375,"name":"Autoimmune hemolytic anemia","classifications":[194]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0001890","label":"Autoimmune hemolytic anemia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002875","label":"Exertional dyspnea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000980","label":"Pallor","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002665","label":"Lymphoma","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002725","label":"Systemic lupus erythematosus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012086","label":"Abnormal urinary color","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003573","label":"Increased total bilirubin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null}]}}