{"orpha":90033,"name":"Autoimmune hemolytic anemia, warm type","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Warm AIHA","wAHA","wAIHA"],"definition":"Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40°C).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90033/","orphanet_url":"https://www.orpha.net/en/disease/detail/90033","names":{"fr":{"name":"Anémie hémolytique auto-immune à auto-anticorps chauds","synonyms":["AIHA chaude","wAHA","wAIHA"],"definition":"L'anémie hémolytique auto-immune à auto-anticorps chauds est une forme d'anémie hémolytique auto-immune (AHAI) définie par la présence d'auto-anticorps anti-érythrocytaires dits « chauds », c'est-à-dire actifs à des températures de 37 à 40 °C."},"de":{"name":"Anämie, autoimmun-hämolytische, Wärme-Typ","definition":"Der Wärmetyp der Autoimmum-hämolytischen Anämie ist die häufigste Form der Autoimmun-hämolytischen Anämie (AIHA; s. dort). Er ist gekennzeichnet durch das Vorhandensein von Wärme-Autoantikörpern gegen Erythrozyten (bei Temperaturen zwischen 37°C und 40°C aktive Autoantikörper). Wärme-Autoantikörper sind für 60-70% der AIHA-Fälle verantwortlich."},"es":{"name":"Anemia autoinmune hemolítica tipo caliente","synonyms":["AHAI caliente","AIHA caliente","wAHA","wAIHA"],"definition":"La anemia hemolítica autoinmune por anticuerpo caliente es la forma más frecuente de anemia hemolítica autoinmune (AIHA; véase este término), caracterizada por la presencia de autoanticuerpos que se activan a temperaturas entre 37 y 40˚C (autoanticuerpos calientes) que atacan a los glóbulos rojos."},"it":{"name":"Anemia emolitica autoimmune, tipo caldo","synonyms":["AIHA calda","wAHA","wAIHA"]},"nl":{"name":"Auto-immune hemolytische anemie, warmte-type","synonyms":["Auto-immune hemolytische anemie met warme auto-antilichamen","Warme AIHA","wAHA","wAIHA"],"definition":"Auto-immune hemolytische anemie, warmte-type is de meest voorkomende vorm van auto-immune hemolytische anemie, gedefinieerd door de aanwezigheid van warme auto-antilichamen (auto-antilichamen die actief zijn bij temperaturen tussen 37-40°C) tegen rode bloedcellen."},"pt":{"name":"Anemia hemolítica autoimune, tipo quente","definition":"A anemia hemolítica auto-imune tipo quente é a forma mais comum de anemia hemolítica auto-imune (ver este termo) definida pela presença de auto-anticorpos contra glóbulos vermelhos quentes (auto-anticorpos que atuam a temperaturas entre 37-40 ° C)."},"pl":{"name":"Niedokrwistość autoimmunohemolityczna typu ciepłego","synonyms":["wAHA","wAIHA","Warm AIHA"]},"cs":{"name":"Autoimunitní hemolytická anémie s tepelnými protilátkami","synonyms":["Tepelná AIHA","wAHA","wAIHA"]},"uk":{"name":"Аутоімунна гемолітична анемія теплого типу","synonyms":["wAHA","wAIHA","Теплий AIHA"],"definition":"Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia (see this term) defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40°C)."},"zh":{"name":"温抗体型自身免疫性溶血性贫血","synonyms":["温抗体型AIHA"]},"tr":{"name":"Otoimmün hemolitik anemi, ılık tip","synonyms":["WAHA","WAIHA","Warm AIHA"]}},"xrefs":[{"source":"ICD-10","code":"D59.1","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"3A20.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"880772122"},{"source":"MONDO","code":"0019532","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0272118","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7876","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10047822","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":98375,"name":"Autoimmune hemolytic anemia","classifications":[194]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.4,"area":"France","status":"Validated","source":"36485114[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-10-18","source":"31412178[PMID]_26043384[PMID]","terms":[{"hpo":"HP:0001890","label":"Autoimmune hemolytic anemia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002875","label":"Exertional dyspnea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000980","label":"Pallor","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0020062","label":"Decreased hemoglobin concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003641","label":"Hemoglobinuria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005523","label":"Lymphoproliferative disorder","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004835","label":"Microspherocytosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001962","label":"Palpitations","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032366","label":"Positive direct antiglobulin test","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0020181","label":"Reduced haptoglobin level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001923","label":"Reticulocytosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008282","label":"Unconjugated hyperbilirubinemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012086","label":"Abnormal urinary color","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005550","label":"Chronic lymphatic leukemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030848","label":"Elevated jugular venous pressure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002725","label":"Systemic lupus erythematosus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null}]}}