{"orpha":86836,"name":"Refractory cytopenia with multilineage dysplasia","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":"Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-86836/","orphanet_url":"https://www.orpha.net/en/disease/detail/86836","names":{"fr":{"name":"Cytopénie réfractaire avec dysplasie multilignée","definition":"Sous-type fréquent de syndrome myélodysplasique (SMD) caractérisé par une ou plusieurs cytopénies du sang périphérique et une dysplasie d'au moins deux lignées myéloïdes."},"de":{"name":"Zytopenie, refraktäre mit multilineärer Dysplasie"},"es":{"name":"Citopenia refractaria con displasia multilineal","definition":"Son un subtipo frecuente de síndrome mielodisplásico (SMD) caracterizado por una o más citopenias en sangre periférica y displasia en dos o más líneas mieloides."},"it":{"name":"Citopenia refrattaria con displasia multilineare","definition":"La citopenia refrattaria con displasia multilineare (RCMD) è una forma comune di sindrome mielodisplastica (MDS; si veda questo termine), caratterizzata da una o più citopenie nel sangue periferico e da displasia in due o più linee mieloidi."},"nl":{"name":"Refractaire cytopenie met multilineaire dysplasie","definition":"Refractaire cytopenie met multilineaire dysplasie (RCMD) is een frequent subtype van myelodysplastisch syndroom (MDS; zie deze term), en wordt gekarakteriseerd door 1 of meer cytopenieën in het perifere bloed en dysplasie in 2 of meer myeloïde afstammelingen."},"pt":{"name":"Citopenia refratária com displasia multilinear"},"pl":{"name":"Cytopenia oporna na leczenie z wieloliniową dysplazją"},"cs":{"name":"Refrakterní cytopenie s multilineární dysplázií"},"uk":{"name":"Рефрактерна цитопенія з мультилінійною дисплазією","definition":"Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS; see this term) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages."},"zh":{"name":"难治性血细胞减少伴多系发育异常"},"tr":{"name":"Multilineage displazi ile seyreden refrakter sitopeni"}},"xrefs":[{"source":"ICD-11","code":"2A34","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1839380478"},{"source":"MONDO","code":"19453","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0796466","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10067959","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":52688,"name":"Myelodysplastic syndrome","classifications":[194,202,233]}],"children":[{"orpha":508542,"name":"Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome","type":"Disease"},{"orpha":98826,"name":"Myelodysplastic neoplasm with low blasts","type":"Disease"},{"orpha":98827,"name":"Unclassified myelodysplastic syndrome","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}