{"orpha":863,"name":"Trichinellosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Trichinosis"],"definition":"Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus <i>Trichinella</i> and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-863/","orphanet_url":"https://www.orpha.net/en/disease/detail/863","names":{"fr":{"name":"Trichinellose","synonyms":["Trichinose"],"definition":"Parasitose zoonotique causée par la consommation de viande crue ou insuffisamment cuite (porc et gibier sauvage) infectée par des nématodes du genre <i>Trichinella</i> qui se caractérise par une phase entérale (intestinale), qui peut être asymptomatique ou se manifester par des diarrhées, des nausées, des vomissements et des douleurs abdominales, et une phase parentérale (musculaire), qui se manifeste par une fièvre, un oedème périorbitaire, un gonflement et des douleurs musculaires, une faiblesse et, dans certains cas, une éruption cutanée et un oedème périphérique. Dans de rares cas, peuvent s'observer des complications cardiaques (myocardite), pulmonaires (pneumonie, insuffisance respiratoire) et du système nerveux (méningo-encéphalite), mettant potentiellement en jeu le pronostic vital."},"de":{"name":"Trichinellose","synonyms":["Trichinose"]},"es":{"name":"Triquinelosis","synonyms":["Triquinosis"],"definition":"Es una enfermedad zoonótica parasitaria producida por el consumo de carne cruda o poco cocinada (cerdo y caza silvestre) infectada por nematodos del género <i>Trichinella</i> y que se caracteriza por una fase enteral (intestinal) que puede ser asintomática o manifestarse con diarrea, náuseas, vómitos y dolor abdominal, y una fase parenteral (muscular) que se manifiesta con fiebre, edema periorbital, inflamación y dolor muscular, debilidad y, en algunos casos, erupción cutánea y edema periférico. Se pueden producir, excepcionalmente, complicaciones cardíacas (miocarditis), pulmonares (neumonitis, insuficiencia respiratoria) y del sistema nervioso (meningoencefalitis), que son potencialmente letales."},"it":{"name":"Trichinellosi","synonyms":["Trichinosi"],"definition":"La trichillenosi è una zoonosi da parassiti causata dal consumo di carne cruda o poco cotta (di maiale e selvaggina) infettata dai nematodi della specie <i>Trichinella.</i> È caratterizzata da una fase enterica (intestinale), che può essere asintomatica oppure esordire con diarrea, nausea, vomito e dolore addominale, seguita da una fase parenterale (muscolare) nella quale il paziente presenta febbre, edema periorbitale, gonfiore e dolore muscolare, debolezza e, in alcuni casi, eruzione cutanea ed edema periferico. Raramente intervengono complicanze cardiache (miocardite), polmonari (polmonite, insufficienza respiratoria) e a livello del sistema nervoso centrale (meningoencefalite) potenzialmente letali."},"nl":{"name":"Trichinellose","synonyms":["Trichinose"],"definition":"Trichinellose is een zoönotische parasitaire ziekte die veroorzaakt wordt door de consumptie van rauw of onvoldoende gekookt vlees (varken en wild) geïnfecteerd met nematoden van het genus <i>Trichinella</i>, en die gekarakteriseerd wordt door een enterale (intestinale) fase, die asymptomatisch kan zijn of zich kan manifesteren met diarree, misselijkheid, braken en buikpijn, en een parenterale (musculaire) fase, die zich manifesteert met koorts, periorbitaal oedeem, zwelling en pijn aan de spieren, zwakte, en in sommige gevallen huiduitslag en perifeer oedeem. Zelden kunnen ook potentieel fatale cardiale (i.e. myocarditis) en pulmonale (i.e. pneumonitis, respiratoire insufficiëntie) complicaties optreden, alsook complicaties aan het zenuwstelsel (i.e. meningo-encefalitis)."},"pt":{"name":"Triquinelose","synonyms":["Triquinose"]},"pl":{"name":"Włośnica","synonyms":["Trichinosis"]},"cs":{"name":"Trichinelóza","synonyms":["Trichinóza"]},"uk":{"name":"Трихінельоз","synonyms":["Трихінельоз"],"definition":"Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus <i>Trichinella</i> and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur."},"zh":{"name":"旋毛虫病","synonyms":["旋毛虫病"]},"tr":{"name":"Trişinolozis","synonyms":["Trikinoz"]}},"xrefs":[{"source":"ICD-10","code":"B75","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F6E","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"284613639"},{"source":"MONDO","code":"0019444","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014235","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0040896","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5250","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044608","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":206997,"name":"Parasitic myositis","classifications":[181]},{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.48,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.067,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.06,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.6,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.64,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-02","source":"23829915[PMID]_11099848[PMID]","terms":[{"hpo":"HP:0030953","label":"Conjunctival hyperemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003457","label":"EMG abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000282","label":"Facial edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001265","label":"Hyporeflexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003212","label":"Increased circulating IgE concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100539","label":"Periorbital edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000496","label":"Abnormality of eye movement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001626","label":"Abnormality of the cardiovascular system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002921","label":"Abnormality of the cerebrospinal fluid","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000741","label":"Apathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001262","label":"Excessive daytime somnolence","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001269","label":"Hemiparesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005986","label":"Limitation of neck motion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002354","label":"Memory impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000602","label":"Ophthalmoplegia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000360","label":"Tinnitus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000211","label":"Trismus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002321","label":"Vertigo","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000587","label":"Abnormal optic nerve morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000553","label":"Abnormal uvea morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0009916","label":"Anisocoria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002381","label":"Aphasia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003487","label":"Babinski sign","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025342","label":"Central retinal artery occlusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001298","label":"Encephalopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010628","label":"Facial palsy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002301","label":"Hemiplegia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000573","label":"Retinal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null}]}}