{"orpha":83594,"name":"Eastern equine encephalitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Eastern equine encephalomyelitis"],"definition":"An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-83594/","orphanet_url":"https://www.orpha.net/en/disease/detail/83594","names":{"fr":{"name":"Encéphalite équine de l'est","synonyms":["Encéphalomyélite équine de l'est"],"definition":"Infection aiguë causée par un arbovirus du genre alphavirus, de la famille des <i>Togaviridae</i> transmis par un moustique infecté, qui se caractérise par l'apparition de symptômes de type fébrile, à savoir fièvre, frissons, faiblesse, maux de tête, vomissements, douleurs abdominales avec diarrhée, myalgie, leucocytose et hématurie, évoluant rapidement vers une atteinte diffuse du système nerveux central (SNC) avec confusion, somnolence, voire coma. Des crises d'épilepsie, pouvant évoluer vers un état de mal épileptique et des séquelles neurologiques, des paralysies des nerfs crâniens et une photophobie peuvent s'observer. La maladie est associée à un taux élevé de morbidité et de létalité."},"de":{"name":"Östliche Pferdeenzephalitis","synonyms":["Eastern-Equine-Encephalitis"]},"es":{"name":"Encefalitis equina oriental","synonyms":["Encefalomielitis equina oriental"],"definition":"Es una infección arboviral aguda causada por un <i>Alfavirus</i> de la familia <i>Togaviridae</i> transmitida por un mosquito infectado. Está caracterizada por la aparición de síntomas similares a la gripe, tales como fiebre, escalofríos, debilidad, cefalea, vómitos, dolor abdominal con diarrea, mialgia, leucocitosis y hematuria, que progresa rápidamente a una afectación difusa del sistema nervioso central (SNC) con confusión, somnolencia e incluso coma. Pueden producirse crisis epilépticas, con posible progresión a estatus epiléptico y con secuelas neurológicas, así como parálisis de nervios craneales y fotofobia. La infección está asociada a una elevada tasa de morbimortalidad."},"it":{"name":"Encefalite equina dell'Est","synonyms":["Encefalomielite equina dell'Est"]},"nl":{"name":"Oosterse paardenencefalitis","synonyms":["Oosterse equine encefalitis","Oosterse paardenencefalomyelitis"],"definition":"Een acute arbovirale infectie veroorzaakt door een <i>alphavirus</i> van de <i>Togaviridae</i>-familie en overgedragen door een geïnfecteerde mug. De infectie wordt gekarakteriseerd door aanvang van griepachtige symptomen zoals koorts, koude rillingen, zwakte, hoofdpijn, braken, abdominale pijn met diarree, myalgie, leukocytose, en hematurie, en evolueert snel tot diffuse betrokkenheid van het centrale zenuwstelsel (CZS) met verwardheid, slaperigheid, of zelfs coma. Insulten, die kunnen evolueren tot status epilepticus en neurologische restverschijnselen, hersenzenuwverlammingen, en fotofobie kunnen ook voorkomen. EEE is geassocieerd met hoge morbiditeit en mortaliteit."},"pt":{"name":"Encefalite equina oriental","synonyms":["Encefalomielite equina oriental"]},"pl":{"name":"Wschodnie końskie zapalenie mózgu","synonyms":["Wschodnie końskie zapalenie mózgu i opon mózgowych"]},"cs":{"name":"Východní koňská encefalitida","synonyms":["Východní koňská encefalomyelitida"]},"uk":{"name":"Східний кінський енцефаліт","synonyms":["Східний енцефаломієліт коней"],"definition":"An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality."},"zh":{"name":"东方马脑炎","synonyms":["东部马脑脊髓炎"]},"tr":{"name":"Doğu at ensefaliti","synonyms":["Doğu at ensefalomiyeliti"]}},"xrefs":[{"source":"ICD-10","code":"A83.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1C84","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"682536148"},{"source":"MONDO","code":"0005736","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D020242","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0153065","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"10821","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10014587","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":166490,"name":"Infectious disease with epilepsy","classifications":[181]},{"orpha":98252,"name":"Infectious encephalitis","classifications":[181,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"United States","status":"Validated","source":"Center for Diseases Control and Prevention 1989-1996[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}