{"orpha":83315,"name":"Murine typhus","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Endemic typhus","Flea-borne typhus"],"definition":"A Rickettsial disease characterized by headache, fever and macular or maculopapular rash, with only one-third of patients manifesting all three symptoms. Other common symptoms are chills, malaise, stomach pain, myalgia, loss of appetite, and in some cases confusion and altered level of consciousness. Classical laboratory abnormalities include elevated liver enzymes, lactate dehydrogenase, erythrocyte sedimentation rate and hypoalbuminemia. In children, typical symptoms occur in only half of patients, and abdominal pain, diarrhea, sore throat and anemia are more common.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-83315/","orphanet_url":"https://www.orpha.net/en/disease/detail/83315","names":{"fr":{"name":"Typhus murin","synonyms":["Typhus endémique"],"definition":"Rickettsiose caractérisée par des céphalées, de la fièvre et une éruption maculaire ou maculopapulaire, seul un tiers des patients présentant les trois symptômes. Parmi les autres symptômes courants figurent : frissons, malaises, douleurs abdominales, myalgies, perte d'appétit et, dans certains cas, confusion et troubles de la conscience. Les anomalies classiques mises en évidence par les analyses biologiques comprennent une élévation des transaminases, de la lactate déshydrogénase, de la vitesse de sédimentation érythrocytaire et une hypoalbuminémie. Chez les patients pédiatriques, les symptômes typiques ne se manifestent que chez la moitié d'entre eux. Les douleurs abdominales, la diarrhée, les maux de gorge et l'anémie sont, quant à eux, plus fréquemment observés chez ces patients."},"de":{"name":"Fleckfieber, murines","synonyms":["Fleckfieber, endemisches","Flohfleckfieber"],"definition":"Eine Rickettsiose, die durch Kopfschmerzen, Fieber und makulösen oder makulopapulösen Ausschlag gekennzeichnet ist, wobei nur ein Drittel der Patienten alle drei Symptome aufweist. Weitere häufige Symptome sind Schüttelfrost, Unwohlsein, Bauchschmerzen, Myalgie, Appetitlosigkeit und in einigen Fällen Verwirrtheit und veränderte Bewusstseinslage. Zu den klassischen Laboranomalien gehören erhöhte Leberenzyme, Laktatdehydrogenase, Erythrozytensedimentationsrate und Hypoalbuminämie. Bei Kindern treten die typischen Symptome nur bei der Hälfte der Patienten auf, häufiger sind Bauchschmerzen, Durchfall, Halsschmerzen und Anämie."},"es":{"name":"Tifus murino","synonyms":["Tifus endémico","Tifus transmitido por pulgas"],"definition":"Es una rickettsiosis caracterizada por cefalea, fiebre y erupción macular o maculopapular, aunque sólo un tercio de los pacientes manifiesta todos estos síntomas. Otros hallazgos frecuentes son escalofríos, malestar general, dolor de estómago, mialgia, pérdida de apetito y, en algunos casos, confusión y alteración del nivel de conciencia. Los hallazgos típicos de laboratorio incluyen un incremento de las enzimas hepáticas y de la lactato deshidrogenasa, una elevación de velocidad de sedimentación globular e hipoalbuminemia. En niños, los síntomas típicos aparecen en tan solo la mitad de los pacientes, siendo los más frecuentes la diarrea, el dolor abdominal y de garganta y la anemia."},"it":{"name":"Tifo murino","definition":"Si tratta di una rickettsiosi caratterizzata da cefalea, febbre ed eruzione maculare o maculo-papulare. Solo un terzo dei pazienti presenta tutti e tre i sintomi. Altri segni clinici comuni sono i brividi, il malessere, il dolore allo stomaco, la mialgia, la perdita dell'appetito e, in alcuni casi, la confusione e le alterazioni dello stato di coscienza. Di solito gli esami di laboratorio evidenziano livelli elevati degli enzimi epatici, della lattato deidrogenasi e della velocità di sedimentazione degli eritrociti, associati a ipoalbuminemia. In età pediatrica, solo la metà dei pazienti presenta i sintomi caratteristici della malattia, mentre sono più comuni il dolore addominale, la diarrea, il mal di gola e l'anemia."},"nl":{"name":"Muriene tyfus","synonyms":["Door vlooien overgedragen tyfus","Endemische vlektyfus"],"definition":"Een Rickettsiose gekarakteriseerd door hoofdpijn, koorts en maculaire of maculopapulaire uitslag, waarbij slechts één derde van de patiënten alle drie de symptomen vertonen. Andere gangbare symptomen zijn rillingen, malaise, maagpijn, myalgie, verlies van eetlust, en in sommige gevallen verwardheid en een gewijzigd niveau van bewustzijn. Klassieke afwijkende laboratoriumuitslagen zijn een verhoging van leverenzymen, lactaatdehydrogenase, erytrocytbezinkingssnelheid en hypoalbuminemie. Bij kinderen komen de typische symptomen slechts bij de helft van de patiënten voor, en zijn buikpijn, diarree, keelpijn en anemie gangbaarder."},"pt":{"name":"Tifo murino"},"pl":{"name":"Dur szczurzy","synonyms":["Endemic typhus","Flea-borne typhus"]},"cs":{"name":"Endemický tyfus","synonyms":["Myší tyfus","Skvrnivka krysí"]},"uk":{"name":"Мишачий висипний тиф","synonyms":["Ендемічний висипний тиф","Блошиний висипний тиф"],"definition":"A Rickettsial disease characterized by headache, fever and macular or maculopapular rash, with only one-third of patients manifesting all three symptoms. Other common symptoms are chills, malaise, stomach pain, myalgia, loss of appetite, and in some cases confusion and altered level of consciousness. Classical laboratory abnormalities include elevated liver enzymes, lactate dehydrogenase, erythrocyte sedimentation rate and hypoalbuminemia. In children, typical symptoms occur in only half of patients, and abdominal pain, diarrhea, sore throat and anemia are more common."},"zh":{"name":"鼠型斑疹伤寒","synonyms":["蚤传播性伤寒"]},"tr":{"name":"Murin tifüs","synonyms":["Endemik tifüs","Pire kaynaklı tifüs"]}},"xrefs":[{"source":"ICD-10","code":"A75.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C30.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"4659958"},{"source":"MONDO","code":"0000330","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014437","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0041472","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10028282","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":102023,"name":"Typhus-group rickettsiosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}