{"orpha":83314,"name":"Epidemic typhus","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A Rickettsial disease characterized by malaise and vague symptoms before the onset of high fever, headache, severe myalgias and less commonly petechial rash on the trunk and limbs, nausea, vomiting, coughing and pneumonia. Most patients also have some central nervous system disturbances, such as meningeal irritation, confusion, drowsiness, seizures, coma, and hearing loss.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-83314/","orphanet_url":"https://www.orpha.net/en/disease/detail/83314","names":{"fr":{"name":"Thyphus épidémique","definition":"Rickettsiose caractérisée par un malaise général et des symptômes non spécifiques précédant l'apparition d'une forte fièvre, de céphalées, de myalgies sévères et plus rarement d'une éruption pétéchiale sur le tronc et les membres, de nausées, de vomissements, d'une toux et d'une pneumonie. La plupart des patients présentent également des troubles du système nerveux central : méningite, confusion, somnolence, convulsions, coma et perte d'audition."},"de":{"name":"Fleckfieber, epidemisches","definition":"Eine Rickettsiose, die durch Unwohlsein und vage Symptome vor Beginn von hohem Fieber, Kopfschmerzen, schweren Myalgien und seltener petechialem Ausschlag am Stamm und an den Gliedmaßen, Übelkeit, Erbrechen, Husten und Lungenentzündung gekennzeichnet ist. Die meisten Patienten zeigen ebenfalls einige Störungen des zentralen Nervensystems, wie z.B. meningeale Reizung, Verwirrung, Schläfrigkeit, Krampfanfälle, Koma und Hörverlust."},"es":{"name":"Tifus epidémico","definition":"Es una rickettsiosis caracterizada por malestar general y síntomas vagos previos al inicio de fiebre alta, cefalea, mialgias intensas y , con menor frecuencia, erupción petequial en el tronco y las extremidades, náuseas, vómitos, tos y neumonía. La mayoría de los pacientes presenta también algún trastorno del sistema nervioso central, como irritación meníngea, confusión, somnolencia, crisis epilépticas, coma y pérdida auditiva."},"it":{"name":"Tifo epidemico","definition":"Si tratta di una rickettsiosi caratterizzata da malessere e sintomi sfumati, che precedono l'insorgenza della febbre elevata, della cefalea, delle mialgie gravi e, più raramente, delle petecchie sul tronco e sugli arti, della nausea, del vomito, della tosse e della polmonite. La maggior parte dei pazienti presenta anche disturbi variabili a livello del sistema nervoso centrale, come l'irritazione delle meningi, la confusione, la sonnolenza, le crisi epilettiche, il coma e la sordità."},"nl":{"name":"Epidemische tyfus","definition":"Een Rickettsiose gekarakteriseerd door malaise en vage symptomen voor aanvang van hoge koorts, hoofdpijn, ernstige spierpijn en minder gangbaar petechiën op de romp en de ledematen, misselijkheid, braken, hoesten en pneumonie. De meeste patiënten vertonen ook enkele stoornissen van het centrale zenuwstelsel, zoals irritatie van de hersenvliezen, verwardheid, slaperigheid, insulten, coma, en gehoorverlies."},"pt":{"name":"Tifo epidémico"},"pl":{"name":"Dur plamisty"},"cs":{"name":"Epidemický tyfus","synonyms":["Skvrnitý tyfus"]},"uk":{"name":"Епідемічний висипний тиф","definition":"A Rickettsial disease characterized by malaise and vague symptoms before the onset of high fever, headache, severe myalgias and less commonly petechial rash on the trunk and limbs, nausea, vomiting, coughing and pneumonia. Most patients also have some central nervous system disturbances, such as meningeal irritation, confusion, drowsiness, seizures, coma, and hearing loss."},"zh":{"name":"流行性斑疹伤寒"},"tr":{"name":"Epidemik tifüs"}},"xrefs":[{"source":"ICD-10","code":"A75.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C30.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"295798687"},{"source":"MONDO","code":"0019362","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"19362","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014438","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0041473","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10014979","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":102023,"name":"Typhus-group rickettsiosis","classifications":[203]}],"children":[{"orpha":99990,"name":"Brill-Zinsser disease","type":"Clinical subtype"},{"orpha":99991,"name":"Relapsing epidemic typhus","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}