{"orpha":83312,"name":"Rickettsialpox","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, acquired, self-limiting, infectious disease due to the mite-borne bacteria <i>Rickettsia akari</i> characterized by an asymptomatic, 0.5 to 2 cm in diameter papulovesicle that typically ulcerates and forms an eschar, followed by a generalized papulovesicular rash associating variable constitutional symptoms, such as localized lymphadenopathy, fever, malaise, and headaches. Additonal symptoms may include diaphoresis, myalgia and, less frequently, rhinorrhea, pharyngitis, nausea, vomiting, splenomegaly, conjunctival hyperemia, and abdominal pain. Systemic symptoms resolve within 6-10 days.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-83312/","orphanet_url":"https://www.orpha.net/en/disease/detail/83312","names":{"fr":{"name":"Fièvre vésiculeuse","definition":"Maladie infectieuse rare, acquise, spontanément résolutive, due à la bactérie <i>Rickettsia akari</i> transmise par les acariens, caractérisée par une papulovésicule asymptomatique de 0,5 à 2 cm de diamètre qui s'ulcère généralement et forme une escarre, suivie d'une éruption papulovésiculaire généralisée associée à des symptômes constitutionnels variables, à savoir lymphadénopathie localisée, fièvre, malaises et céphalées. Parmi les autres symptômes peuvent figurer une diaphorèse, une myalgie et, moins fréquemment, une rhinorrhée, une pharyngite, des nausées, des vomissements, une splénomégalie, une hyperémie conjonctivale et des douleurs abdominales. Les symptômes systémiques disparaissent en 6 à 10 jours."},"de":{"name":"Rickettsienpocken","definition":"Eine seltene, erworbene, selbstlimitierende Infektionskrankheit, die durch das von Milben übertragene Bakterium <i>Rickettsia akari</i> verursacht wird. Sie ist gekennzeichnet durch eine asymptomatische Papulovesikel mit einem Durchmesser von 0,5 bis 2 cm, die typischerweise ulzeriert und einen Schorf bildet, gefolgt von einem generalisierten papulovesikulären Ausschlag, der mit variablen konstitutionellen Symptomen wie lokalisierter Lymphadenopathie, Fieber, Unwohlsein und Kopfschmerzen einhergeht. Zu den zusätzlichen Symptomen können Diaphorese, Myalgie und, seltener, Rhinorrhoe, Pharyngitis, Übelkeit, Erbrechen, Splenomegalie, konjunktivale Hyperämie und Bauchschmerzen gehören. Die systemischen Symptome klingen innerhalb von 6-10 Tagen ab."},"es":{"name":"Rickettsiosis exantemática","definition":"Es una enfermedad infecciosa adquirida poco frecuente y autolimitada provocada por la bacteria <i>Rickettsia akari</i>, transmitida por ácaros. Está caracterizada por una papulovesícula asintomática de 0,5 a 2 cm de diámetro que, por lo general, se ulcera y forma una escara, seguida por una erupción papulovesicular generalizada que asocia síntomas constitucionales variables, tales como linfadenopatía localizada, fiebre, malestar general y cefaleas. Otros síntomas adicionales pueden incluir diaforesis, mialgia y, con menor frecuencia, rinorrea, faringitis, náusea, vómitos, esplenomegalia, hiperemia conjuntival y dolor abdominal. Los síntomas sistémicos remiten en 6-10 días."},"it":{"name":"Esantema da rickettsia","definition":"È una malattia infettiva acquisita rara autolimitante causata dai batteri <i>Rickettsia akari</i> tramessi dagli acari. È caratterizzata da una vescicola papulosa asintomatica, dal diametro compreso tra 0,5 e 2 cm, che di solito va incontro ad ulcerazione con conseguente formazione di un'escara, seguita da un'eruzione papulo-vescicolare generalizzata. Si associa a sintomi costituzionali variabili, che comprendono la linfoadenopatia localizzata, la febbre, il malessere e la cefalea. Altri segni clinici sono la diaforesi, la mialgia e, più raramente, la rinorrea, la faringite, la nausea, il vomito, la splenomegalia, iperemia della congiuntiva e il dolore addominale. I sintomi sistemici scompaiono nell'arco di 6-10 giorni."},"nl":{"name":"Rickettsiapokken","definition":"Een zeldzame, verworven, zelflimiterende infectieziekte veroorzaakt door de bacterie <i>Rickettsia akari</i>, die wordt overgedragen door mijten. De ziekte wordt gekarakteriseerd door een asymptomatisch papulovesikel met een diameter van 0,5 tot 2 cm dat doorgaans verzweert en een eschar vormt, gevolgd door een gegeneraliseerde papulovesiculaire uitslag die variabele constitutionele symptomen associeert, zoals gelokaliseerde lymfadenopathie, koorts, malaise, en hoofdpijn. Mogelijke bijkomende symptomen zijn onder meer diaforese, myalgie en, minder frequent, rinorroe, faryngitis, misselijkheid, braken, splenomegalie, hyperemie van de conjunctiva, en buikpijn. Systemische symptomen verdwijnen binnen 6-10 dagen."},"pt":{"name":"Rickettsiose variceliforme"},"pl":{"name":"Ospa riketsjowa"},"cs":{"name":"Rickettsiové neštovice"},"uk":{"name":"Рикетсіозна віспа","definition":"A rare, acquired, self-limiting, infectious disease due to the mite-borne bacteria <i>Rickettsia akari</i> characterized by an asymptomatic, 0.5 to 2 cm in diameter papulovesicle that typically ulcerates and forms an eschar, followed by a generalized papulovesicular rash associating variable constitutional symptoms, such as localized lymphadenopathy, fever, malaise, and headaches. Additonal symptoms may include diaphoresis, myalgia and, less frequently, rhinorrhea, pharyngitis, nausea, vomiting, splenomegaly, conjunctival hyperemia, and abdominal pain. Systemic symptoms resolve within 6-10 days."},"zh":{"name":"立克次体痘疹"},"tr":{"name":"Ricketsiyal çiçek hastalığı"}},"xrefs":[{"source":"ICD-10","code":"A79.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C32","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1005140361"},{"source":"MONDO","code":"0019360","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000073605","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0035597","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039137","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":102022,"name":"Spotted fever rickettsiosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":800.0,"area":"Worldwide","status":"Validated","source":"15577753[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}