{"orpha":83311,"name":"Rocky Mountain spotted fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, acquired, life-threatening, infectious disease due to the tick-borne bacteria <i>Rickettsia rickettsii</i> characterized by an acute onset of fever, malaise, and severe headache, variably accompanied by myalgia, anorexia, nausea, vomiting, abdominal pain, and photophobia, associating (2-5 days after fever onset) a typically erythematous, blanching or non-blanching, maculopapluar rash with petechiae, starting on the wrists and ankles and progressing centrifugally to the palms and soles and centripetally to the arms, legs and trunk. Additonal variable features may include conjunctivitis, mucosal ulcers, post-inflammatory hyperpigmentation, jaundice, pneumonia, hepatomegaly, renal failure, meningismus, amnesia, optic disc edema, and ocular arterial occlusion.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-83311/","orphanet_url":"https://www.orpha.net/en/disease/detail/83311","names":{"fr":{"name":"Fièvre pourprée des Montagnes Rocheuses","definition":"Maladie infectieuse rare, acquise, potentiellement létale, due à la bactérie <i>Rickettsia rickettsii</i> transmise par les tiques, caractérisée par l'apparition d'une forte fièvre, d'un malaise et de violents maux de tête, accompagnés de façon variable de myalgie, d'anorexie, de nausées, de vomissements, de douleurs abdominales et de photophobie, associant (deux à cinq jours après l'apparition de la fièvre) une éruption maculo-papuleuse typiquement érythémateuse, blanchissante ou non, avec des pétéchies, affectant d'abord les poignets et les chevilles et progressant de manière centrifuge vers les paumes des mains et les plantes des pieds et de manière centripète vers les bras, les jambes et le tronc. D'autres caractéristiques sont inconstantes et peuvent inclure : conjonctivite, ulcères muqueux, hyperpigmentation post-inflammatoire, ictère, pneumonie, hépatomégalie, insuffisance rénale, méningisme, amnésie, oedème papillaire et occlusion veineuse rétinienne."},"de":{"name":"Rocky-Mountain-Fleckfieber","definition":"Eine erworbene lebensbedrohliche Infektionskrankheit, die durch das von Zecken übertragene Bakterium <i>Rickettsia rickettsii</i> verursacht wird und durch akut einsetzendes Fieber, Unwohlsein und starke Kopfschmerzen gekennzeichnet ist. Die Manifestationen können Myalgie, Anorexie, Übelkeit, Erbrechen, Bauchschmerzen und Photophobie umfassen, einhergehend (2-5 Tage nach Fieberbeginn) mit einem typischerweise erythematösen, bleichenden oder nicht bleichenden, makulopapulösen Ausschlag mit Petechien, der an den Hand- und Fußgelenken beginnt und zentral auf die Handflächen und Fußsohlen sowie zentral auf Arme, Beine und Rumpf übergeht. Weitere variable Merkmale sind Konjunktivitis, Schleimhautgeschwüre, postinflammatorische Hyperpigmentierung, Gelbsucht, Lungenentzündung, Hepatomegalie, Nierenversagen, Meningismus, Amnesie, Sehnervenödem und Okklusion der Augenarterien."},"es":{"name":"Fiebre maculosa de las Montañas Rocosas","definition":"Es una enfermedad infecciosa adquirida potencialmente mortal y poco frecuente causada por la bacteria <i>Rickettsia rickettsii</i> transmitida por garrapatas. Está caracterizada por un inicio agudo de fiebre, malestar general y grave cefalea, acompañado, de forma variable, por mialgia, anorexia, náusea, vómitos, dolor abdominal y fotofobia asociada con (2-5 días después del inicio de la fiebre) una erupción maculopapular eritematosa típica, blanqueadora o no blanqueadora con petequias, que se origina en las muñecas y los tobillos con progresión centrífuga a las palmas y las plantas y centrípeta hacia los brazos, las piernas y el tronco. Otros hallazgos variables adicionales pueden incluir conjuntivitis, úlceras mucosas, hiperpigmentación postinflamatoria, ictericia, neumonía, hepatomegalia, insuficiencia renal, meningismo, amnesia, edema del disco óptico y oclusión arterial retiniana."},"it":{"name":"Febbre maculosa delle Montagne Rocciose","definition":"È una malattia infettiva acquisita rara, potenzialmente letale, causata dal batterio tramesso dalle zecche <i>Rickettsia rickettsii</i>; è caratterizzata da febbre ad esordio acuto, malessere e grave cefalea, variabilmente associati a mialgia, anoressia, nausea, vomito, dolore addominale e fotofobia. Due-cinque giorni dopo l'esordio della febbre, compare un'eruzione maculo-papulare, di solito eritematosa, che schiarisce o non schiarisce, associata a petecchie, ad esordio dapprima sui polsi e sulle caviglie con successiva progressione centrifuga verso il palmo delle mani e la pianta dei piedi, e centripeta verso le braccia, le gambe e il tronco. Altri segni clinici variabili comprendono la congiuntivite, l'ulcerazione della mucosa, l'iperpigmentazione post-infiammatoria, l'ittero, la polmonite, l'epatomegalia, l'insufficienza renale, il meningismo, l'amnesia, l'edema del disco ottico e l'occlusione dell'arteria oftalmica."},"nl":{"name":"Rocky Mountain-vlekkenkoorts","definition":"Een zeldzame, verworven, levensbedreigende infectieziekte veroorzaakt door de door teken overgedragen bacterie <i>Rickettsia rickettsii</i> en gekarakteriseerd door een acute aanvang van koorts, malaise, en ernstige hoofdpijn, variabel vergezeld van myalgie, anorexie, misselijkheid, braken, buikpijn en fotofobie, geassocieerd (2-5 dagen na aanvang van koorts) met een typisch erythemateuze, al dan niet verblekende, maculopapulaire uitslag met petechiën die begint op de polsen en enkels en centrifugaal evolueert naar de palmen en zolen en centripetaal naar de armen, benen en romp. Mogelijke bijkomende variabele kenmerken zijn onder meer bindvliesontsteking, zweren in het slijmvlies, post-inflammatoire hyperpigmentatie, geelzucht, pneumonie, hepatomegalie, nierfalen, meningisme, amnesie, oedeem van de optische papil, en oculaire arteriële occlusie."},"pt":{"name":"Febre maculosa das Montanhas Rochosas"},"pl":{"name":"Gorączka plamista z Gór Skalistych"},"cs":{"name":"Horečka Skalistých hor"},"uk":{"name":"Плямиста лихоманка Скелястих гір","definition":"A rare, acquired, life-threatening, infectious disease due to the tick-borne bacteria <i>Rickettsia rickettsii</i> characterized by an acute onset of fever, malaise, and severe headache, variably accompanied by myalgia, anorexia, nausea, vomiting, abdominal pain, and photophobia, associating (2-5 days after fever onset) a typically erythematous, blanching or non-blanching, maculopapluar rash with petechiae, starting on the wrists and ankles and progressing centrifugally to the palms and soles and centripetally to the arms, legs and trunk. Additonal variable features may include conjunctivitis, mucosal ulcers, post-inflammatory hyperpigmentation, jaundice, pneumonia, hepatomegaly, renal failure, meningismus, amnesia, optic disc edema, and ocular arterial occlusion."},"zh":{"name":"落矶山斑疹热"},"tr":{"name":"Kayalık Dağlar benekli humması"}},"xrefs":[{"source":"ICD-10","code":"A77.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C31.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"215936800"},{"source":"MONDO","code":"0019359","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012373","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0035793","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7585","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039207","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":102022,"name":"Spotted fever rickettsiosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.24,"area":"United States","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}