{"orpha":810,"name":"Shigellosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare bacterial infectious disease characterized by dysentery caused by Shigella. There are four species (S. dysenteriae, S. flexneri, S. boydii and S. sonnei), all of which cause bacillary dysentery and are strictly limited to human hosts. Affected individuals present with dysenteric syndrome with 10-30 glairy, bloody and watery stools per day, a high temperature (40°C), abdominal pain/cramps and tenesmus following an incubation period of 2-3 days.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-810/","orphanet_url":"https://www.orpha.net/en/disease/detail/810","names":{"fr":{"name":"Shigellose","definition":"Les shigelles sont de petits bacilles à Gram négatif strictement humains, ubiquitaires, appartenant au groupe des entérobactéries. On dénombre quatre espèces : <i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> et <i>S. sonnei</i>, responsables de la dysenterie bacillaire."},"de":{"name":"Shigellose","definition":"Die durch Shigella verursachte Ruhr ist eine seltene bakterielle Infektionskrankheit. Es gibt vier Arten (<i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> und <i>S. sonnei</i>), die alle eine Bakterien-Dysenterie verursachen und ausschließlich den Menschen als Wirt befallen. Betroffene Personen leiden nach einer Inkubationszeit von zwei bis drei Tagen unter einem dysenterischen Syndrom mit zehn bis 30 schleimigen, blutigen und wässrigen Stuhlgängen pro Tag, hohem Fieber (40 °C), Bauchschmerzen/Krämpfen und Tenesmus."},"es":{"name":"Shigelosis","definition":"Es una enfermedad infecciosa de origen bacteriano poco frecuente caracterizada por disentería causada por <i>Shigella</i>. Hay cuatro especies: <i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> y <i>S. sonnei</i>, todas ellas causantes de disentería bacilar y que se limitan estrictamente a huéspedes humanos. Tras un período de incubación de 2 a 3 días, se manifiesta el síndrome disentérico con 10 a 30 deposiciones líquidas, sanguinolentas y glabras al día, fiebre alta (40 °C) y dolor abdominal."},"it":{"name":"Shighellosi"},"nl":{"name":"Shigellose","definition":"Een zeldzame bacteriële infectieuze aandoening, gekenmerkt door dysenterie veroorzaakt door Shigella. Er bestaan vier soorten (<i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> en <i>S. sonnei</i>), die allen bacillaire dysenterie veroorzaken en strikt beperkt blijven tot mensen als gastheer. Getroffen individuen presenteren zich met dysenterie-syndroom met 10-30 slijmerige, bloederige en waterige ontlastingen per dag, een hoge temperatuur (40°C), abdominale pijn/krampen en tenesmus na een incubatieperiode van 2-3 dagen."},"pt":{"name":"Shigelose","definition":"A shigellose é uma infecção bacteriana que leva a disenteria e é causada pelas <i>Shigella</i>, que são pequenas bactérias Gram-negativo, ubíquoas, pertencentes à família enterobacteria. Existem quatro espécies: <i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> e <i>S. sonnei</i>, todas causam disenteria bacilar e estão estritamente limitadas a hospedeiros humanos."},"pl":{"name":"Szigelloza"},"cs":{"name":"Shigelóza"},"uk":{"name":"Шигельоз","definition":"Shigellosis is a bacterial infection leading to dysentery and is caused by <i>Shigella</i>, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: <i>S. dysenteriae</i>, <i>S. flexneri</i>, <i>S. boydii</i> and <i>S. sonnei</i>, all of which cause bacillary dysentery and are strictly limited to human hosts."},"zh":{"name":"细菌性痢疾"},"tr":{"name":"Şigelloz"}},"xrefs":[{"source":"ICD-10","code":"A03.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A03.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A03.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A03.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A03.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A03.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1A02","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2080365623"},{"source":"MONDO","code":"0019345","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0013371","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"4818","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10054178","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.68,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.18,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.33,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.6,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.08,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.38,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.82,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.78,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.54,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.7,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.74,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.38,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.12,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.34,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.12,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.6,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.34,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.4,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.18,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.1,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.02,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.44,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.68,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.32,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Iceland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.06,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-02","source":"27556171[PMID]_24891600[PMID]_17399943[PMID]","terms":[{"hpo":"HP:0032155","label":"Abdominal cramps","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025086","label":"Bloody mucoid diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003111","label":"Abnormal blood ion concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025406","label":"Asthenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001944","label":"Dehydration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012702","label":"Tenesmus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025615","label":"Abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100282","label":"Acute colitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025085","label":"Bloody diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001531","label":"Failure to thrive in infancy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002373","label":"Febrile seizure (within the age range of 3 months to 6 years)","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001943","label":"Hypoglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031274","label":"Hypovolemic shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002590","label":"Paralytic ileus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100279","label":"Ulcerative colitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031864","label":"Bacteremia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001396","label":"Cholestasis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012804","label":"Corneal ulceration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005575","label":"Hemolytic-uremic syndrome","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031368","label":"Intestinal perforation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001937","label":"Microangiopathic hemolytic anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025059","label":"Splenic abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0500006","label":"Urethritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001025","label":"Urticaria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Very rare (<4-1%)","criteria":null}]}}