{"orpha":797,"name":"Sarcoidosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Besnier-Boeck-Schaumann disease","Boeck sarcoid"],"definition":"A rare multisystemic, autoinflammatory disorder of unknown etiology characterized by the formation of immune, non-caseating granulomas in any organ(s), leading to variable clinical symptoms and severity. Clinical presentation is typically with persistent dry cough, eye or skin manifestations, peripheral lymph nodes, fatigue, weight loss, fever or night sweats, and Löfgren syndrome.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-797/","orphanet_url":"https://www.orpha.net/en/disease/detail/797","names":{"fr":{"name":"Sarcoïdose","synonyms":["BBS","Maladie de Besnier-Boeck-Schaumann","Maladie de Boeck"],"definition":"Maladie auto-inflammatoire multisystémique rare de cause inconnue, caractérisée par le développement de granulomes immunisés non caséeux affectant tous les organes et dont les symptômes cliniques et la sévérité sont variables. Les manifestations cliniques typiques sont une toux sèche persistante, des atteintes oculaires et cutanées, des adénopathies périphériques, une fatigue, une perte de poids, de la fièvre ou des sueurs nocturnes et le syndrome de Löfgren."},"de":{"name":"Sarkoidose","synonyms":["Besnier-Boeck-Schaumann-Krankheit","Boeck-Krankheit"],"definition":"Eine multisystemische autoinflammatorische Erkrankung unbekannter Ätiologie, die durch die Bildung von immunologisch bedingten, nicht karzinomatösen Granulomen in einem oder mehreren Organen mit unterschiedlichen klinischen Symptomen und Schweregraden gekennzeichnet ist. Die klinische Präsentation ist typischerweise durch anhaltenden trockenen Husten, Augen- oder Hautmanifestationen, periphere Lymphknoten, Müdigkeit, Gewichtsverlust, Fieber oder nächtliche Schweißausbrüche und das Löfgren-Syndrom gekennzeichnet."},"es":{"name":"Sarcoidosis","synonyms":["Enfermedad de Besnier-Boeck-Schaumann","Enfermedad de Boeck"],"definition":"Es un trastorno autoinflamatorio multisistémico poco frecuente de etiología desconocida caracterizado por la formación de granulomas inmunitarios no caseificantes en cualquier órgano u órganos, lo que da lugar a síntomas clínicos de gravedad variable. La presentación clínica es típicamente con tos seca persistente, manifestaciones oculares o cutáneas, ganglios linfáticos periféricos, cansancio, pérdida de peso, fiebre o sudores nocturnos y síndrome de Löfgren."},"it":{"name":"Sarcoidosi","synonyms":["Malattia di Besnier-Boeck-Schaumann","Malattia di Boeck"],"definition":"La sarcoidosi è una malattia multisistemica autoinfiammatoria rara, le cui cause non sono note. È caratterizzata dalla formazione di granulomi immuni non caseosi in uno o più organi, associata a segni clinici di gravità variabile. In genere i pazienti presentano tosse secca persistente, sintomi oculari o cutanei, ingrossamento dei linfonodi periferici, affaticamento, perdita di peso, febbre o sudorazione notturna e sindrome di Löfgren."},"nl":{"name":"Sarcoïdose","synonyms":["Sarcoïd van Boeck","Ziekte van Besnier-Boeck-Schaumann"],"definition":"Een zeldzame, multisystemische auto-inflammatoire aandoening met ongekende etiologie, gekarakteriseerd door vorming van immune granulomen zonder caseum (kaasachtig centrum) in eender welk orgaan, met variabele klinische symptomen en gradaties van ernst. Het klinische beeld omvat doorgaans persisterende droge hoest, manifestaties van oog en huid, perifere adenopathie, vermoeidheid, gewichtsverlies, koorts of nachtzweten, en syndroom van Löfgren."},"pt":{"name":"Sarcoidose","synonyms":["Doença de Besnier-Boeck-Schaumann","Sarcoide de Boeck"]},"pl":{"name":"Sarkoidoza","synonyms":["Choroba Besniera, Boecka i Schaumanna"]},"cs":{"name":"Sarkoidóza","synonyms":["Besnierova-Boeckova-Schaumannova choroba","Boeckova sarkoidóza","Besnier-Boeck-Schaumannova choroba"]},"uk":{"name":"Саркоїдоз","synonyms":["Хвороба Бесніє-Бека-Шомана","Саркоїд Бека"],"definition":"A rare multisystemic, autoinflammatory disorder of unknown etiology characterized by the formation of immune, non-caseating granulomas in any organ(s), leading to variable clinical symptoms and severity. Clinical presentation is typically with persistent dry cough, eye or skin manifestations, peripheral lymph nodes, fatigue, weight loss, fever or night sweats, and Löfgren syndrome."},"zh":{"name":"结节病","synonyms":["Besnier-Boeck-Schaumann病"]},"tr":{"name":"Sarkoidoz","synonyms":["Boeck sarkoid","Besnier-Boeck-Schaumann hastalığı"]}},"xrefs":[{"source":"OMIM","code":"181000","qualifier":"E","icd_relation":null,"validated":true},{"source":"OMIM","code":"612387","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"OMIM","code":"612388","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"D86.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"D86.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"D86.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"D86.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"D86.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"D86.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"4B20","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"330792642"},{"source":"ICD-11","code":"4B20.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"820827059"},{"source":"ICD-11","code":"4B20.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1437015591"},{"source":"ICD-11","code":"4B20.2","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1434414203"},{"source":"ICD-11","code":"4B20.3","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1479285656"},{"source":"ICD-11","code":"4B20.4","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1980319000"},{"source":"ICD-11","code":"4B20.5","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1145144140"},{"source":"MONDO","code":"0019338","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012507","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0036202","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7607","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039486","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":324930,"name":"Granulomatous autoinflammatory syndrome","classifications":[196]},{"orpha":166484,"name":"Inflammatory and autoimmune disease with epilepsy","classifications":[181]},{"orpha":217720,"name":"Non-familial restrictive cardiomyopathy","classifications":[146]},{"orpha":567558,"name":"Non-genetic systemic disease with glomerulopathy as a major feature","classifications":[188,233]},{"orpha":95617,"name":"Pituitary hormone deficiency secondary to a granulomatous disease","classifications":[193]},{"orpha":280373,"name":"Rare pediatric systemic disease","classifications":[231]},{"orpha":182222,"name":"Rare systemic disease","classifications":[196]},{"orpha":264745,"name":"Secondary interstitial lung disease specific to adulthood associated with a systemic disease","classifications":[184,233]},{"orpha":280926,"name":"Systemic diseases with anterior uveitis","classifications":[189]},{"orpha":280933,"name":"Systemic diseases with panuveitis","classifications":[189]},{"orpha":280930,"name":"Systemic diseases with posterior uveitis","classifications":[189]},{"orpha":209007,"name":"Systemic inflammatory disease associated with an acquired peripheral neuropathy","classifications":[181]}],"children":[],"genes":[{"symbol":"BTNL2","name":"butyrophilin like 2","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"15735647[PMID]","hgnc":"1142","ensembl":"ENSG00000204290","omim":"606000","loci":["6p21.32"]},{"symbol":"HLA-DRB1","name":"major histocompatibility complex, class II, DR beta 1","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"22991420[PMID]","hgnc":"4948","ensembl":"ENSG00000196126","omim":"142857","loci":["6p21.32"]}],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Worldwide","status":"Validated","source":"[EXPERT]_ORPHANET_DOI:10.1016/B978-0-323-54429-0.00001-X[OTHER]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":48.1,"area":"Ireland","status":"Validated","source":"[EXPERT]_DOI:10.1016/B978-0-323-54429-0.00001-X[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.3,"area":"Croatia","status":"Validated","source":"21906764[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":20.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2007[OTHER]_DOI:10.1016/B978-0-323-54429-0.00001-X[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.0,"area":"United Kingdom","status":"Validated","source":"16844727[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":30.2,"area":"France","status":"Validated","source":"28775045 [PMID]_[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.5,"area":"Spain","status":"Validated","source":"21546016[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":28.2,"area":"Finland","status":"Validated","source":"7617979[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.68,"area":"Denmark","status":"Validated","source":"18983653[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":7.0,"area":"Switzerland","status":"Validated","source":"19897550[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"Switzerland","status":"Validated","source":"DOI:10.1016/B978-0-323-54429-0.00001-X[OTHER]_[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.07,"area":"Greece","status":"Validated","source":"19345567[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":5.89,"area":"Greece","status":"Validated","source":"19345567[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.84,"area":"Iceland","status":"Validated","source":"17277405[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.0,"area":"Czech Republic","status":"Validated","source":"7809493[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"6-9 / 10 000","value":63.0,"area":"Czech Republic","status":"Validated","source":"7809493[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.35,"area":"Australia","status":"Validated","source":"17535377[PMID]_ORPHANET_[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.01,"area":"Japan","status":"Validated","source":"17959635[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":3.7,"area":"Japan","status":"Validated","source":"7617979[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.125,"area":"Korea, Republic of","status":"Validated","source":"11436538[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.56,"area":"Singapore","status":"Validated","source":"17539838[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"6-9 / 10 000","value":60.0,"area":"United States","status":"Validated","source":"2750915[PMID]_[EXPERT]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":49.0,"area":"Italy","status":"Validated","source":"28475583[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.9,"area":"France","status":"Validated","source":"28775045 [PMID]_[EXPERT]"},{"type":"Point prevalence","qualification":"Value and class","class":">1 / 1000","value":160.0,"area":"Sweden","status":"Validated","source":"27471207[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":11.5,"area":"Sweden","status":"Validated","source":"27471207[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":2.17,"area":"Taiwan, Province of China","status":"Validated","source":"27786368 [PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"Portugal","status":"Validated","source":"5884467[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":26.7,"area":"Norway","status":"Validated","source":"5884453[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":14.4,"area":"Norway","status":"Validated","source":"5884453[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.5,"area":"Canada","status":"Validated","source":"5884470[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":21.0,"area":"Guadeloupe","status":"Validated","source":"24962008[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.3,"area":"Guadeloupe","status":"Validated","source":"24962008[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.4,"area":"Uruguay","status":"Validated","source":"5884475[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-02-15","source":"10430755[PMID]","terms":[{"hpo":"HP:0002088","label":"Abnormal lung morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011121","label":"Abnormal skin morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003011","label":"Abnormality of the musculature","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002103","label":"Abnormality of the pleura","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001410","label":"Decreased liver function","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100828","label":"Increased T cell count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200036","label":"Skin nodule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030872","label":"Abnormal cardiac ventricular function","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000502","label":"Abnormal conjunctiva morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030146","label":"Abnormal liver parenchyma morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012243","label":"Abnormal reproductive system morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002921","label":"Abnormality of the cerebrospinal fluid","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011024","label":"Abnormality of the gastrointestinal tract","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002733","label":"Abnormality of the lymph nodes","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000433","label":"Abnormality of the nasal mucosa","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001596","label":"Alopecia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000618","label":"Blindness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012062","label":"Bone cyst","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002110","label":"Bronchiectasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000518","label":"Cataract","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010310","label":"Chylothorax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000620","label":"Dacryocystitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000873","label":"Diabetes insipidus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002097","label":"Emphysema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007734","label":"Enlarged lacrimal glands","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011801","label":"Enlargement of parotid gland","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010628","label":"Facial palsy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000501","label":"Glaucoma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012722","label":"Heart block","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003072","label":"Hypercalcemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002150","label":"Hypercalciuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000953","label":"Hyperpigmentation of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001010","label":"Hypopigmentation of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001097","label":"Keratoconjunctivitis sicca","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033505","label":"Livedo reticularis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000121","label":"Nephrocalcinosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000787","label":"Nephrolithiasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011850","label":"Parotitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001409","label":"Portal hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003701","label":"Proximal muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002206","label":"Pulmonary fibrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100699","label":"Scarring","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200035","label":"Skin plaque","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001482","label":"Subcutaneous nodule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001970","label":"Tubulointerstitial nephritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002781","label":"Upper airway obstruction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004756","label":"Ventricular tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000834","label":"Abnormality of the adrenal glands","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001878","label":"Hemolytic anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000836","label":"Hyperthyroidism","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002045","label":"Hypothermia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000821","label":"Hypothyroidism","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001880","label":"Increased total eosinophil count","frequency":"Very rare (<4-1%)","criteria":null}]}}