{"orpha":79492,"name":"Pili gemini","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Pili multigemini"],"definition":"A rare isolated hair shaft abnormality characterized by multiple hair shafts arise from a single pilosebaceous canal and emerge from a single follicular ostium. It can occur in each type of hair; mostly in bread of men or in the other uncommon locations of the body (such as the back or abdomen). Folliculitis may also be present. Most of the patients are asymptomatic, however, some may present with recurrent inflammatory lesions which can have residual atrophic or hypertrophic scars. Persisting itching is also reported in some patients.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-79492/","orphanet_url":"https://www.orpha.net/en/disease/detail/79492","names":{"fr":{"name":"Pili gemini","synonyms":["Pili multigemini"],"definition":"Le pili gemini décrit la stuation où la pointe de la papille d'un follicule pileux se divise pendant la phase anagène, donnant naissance à deux tiges de cheveux qui émergent du même canal pilaire. Quand une papille se divise en plusieurs pointes, elle produit plusieurs tiges de cheveux : c'est un pili multigemini. Le pili gemini ou multigemini affecte tous les types de cheveux."},"de":{"name":"Pili gemini","synonyms":["Pili multigemini"],"definition":"Mit Pili gemini wird eine Situation beschrieben, in der sich die Papillenspitze eines Haarfollikels während der Anagen-Phase aufspaltet und danach zwei Haarschäfte aus einem einzelnen Haarkanal herauswachsen. Eine Papillenspitze, die sich in mehrere Spitzen aufteilt, produziert mehrere Haarschäfte. Diese Situation wird Pili multigemini genannt. Pili gemini oder multigemini können in jedem Haartyp auftreten."},"es":{"name":"Pili gemini","synonyms":["Pili multigemini"],"definition":"Pili gemini define una situación en la que la punta de la papila del folículo piloso se divide en la fase anágena, dando lugar al crecimiento de dos tallos pilosos que emergen a través de un único canal piloso. Si la punta de una papila se divide en varios tallos producirá varios cabellos, una situación denominada pili multigemini. Tanto pili gemini como multigemini pueden producirse en todo tipo de cabello."},"it":{"name":"Pili gemini","synonyms":["Pili multigemini"],"definition":"La definizione pili gemini descrive la situazione in cui la punta della papilla di un follicolo pilifero si spacca durante la fase anagen e, di conseguenza, si creano due fusti piliferi che originano da un singolo canale pilare. La punta di una papilla che si suddivide in diverse punte produce diversi fusti piliferi, una condizione nota come pili multigemini. I pili gemini o multigemini possono insorgere in qualunque tipo di capelli."},"nl":{"name":"Pili gemini","synonyms":["Pili multigemini"],"definition":"Een zeldzame geïsoleerde afwijking van haarschacht, gekenmerkt door meerdere haarschachten die ontspringen uit één enkel pilosebaceus kanaal en uittreden uit één enkel folliculair ostium. Het kan optreden bij elk type van haar, vooral in baarden van mannen of op andere minder gangbare plaatsen op het lichaam (zoals rug of abdomen). Folliculitis kan ook aanwezig zijn. De meeste patiënten zijn asymptomatisch, maar sommigen kunnen echter recidiverende inflammatoire laesies vertonen, mogelijk met residuele atrofie of hypertrofische littekens. Aanhoudende jeuk wordt ook gerapporteerd bij sommige patiënten."},"pt":{"name":"Pili multigemini","definition":"Pili gemini define uma situação em que a ponta de um folículo piloso da papila se divide durante a fase anágena e, consequentemente, crescem dois fios de cabelo através de um único canal piloso. Uma ponta de papila que se divide em várias pontas vai produzir vários fios de cabelo, uma situação chamada pili multigemini. Pili gemini ou multigemini podem ocorrer em cada tipo de cabelo."},"pl":{"name":"Włosy bliźniacze","synonyms":["Pili multigemini"]},"cs":{"name":"Pili gemini","synonyms":["Pili multigemini"]},"uk":{"name":"Мультипліковані волосини (Pili gemini)","synonyms":["Pili multigemini"],"definition":"Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair."},"zh":{"name":"双菌毛","synonyms":["双菌毛"]},"tr":{"name":"Pili gemini","synonyms":["Pili multigemini"]}},"xrefs":[{"source":"ICD-10","code":"L67.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"ED73.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"573280555"},{"source":"MONDO","code":"0019330","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C537188","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0019571","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":79366,"name":"Isolated hair shaft abnormality","classifications":[156,187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-06-17","source":"10882940[PMID]","terms":[{"hpo":"HP:0003329","label":"Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes","frequency":"Obligate (100%)","criteria":null},{"hpo":"HP:0003328","label":"Abnormal hairshaft morphology","frequency":"Frequent (79-30%)","criteria":null}]}}