{"orpha":79088,"name":"Localized lipodystrophy","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":"A rare group of acquired lipodystrophies that are characterized by loss of subcutaneous tissue from generally small regions of the body, either single or multiple areas, and are not typically associated with metabolic complications. Some cases may involve lipohypertrophy (insulin). This group includes pressure-induced localized lipoatrophy, drug-induced localized lipodystrophy, panniculitis- induced localized lipodystrophy, centrifugal lipodystrophy, and idiopathic localized lipodystrophy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-79088/","orphanet_url":"https://www.orpha.net/en/disease/detail/79088","names":{"fr":{"name":"Lipodystrophie localisée","definition":"Groupe rare de lipodystrophies acquises qui se caractérisent par une perte de tissu sous-cutané affectant généralement des zones peu étendues du corps, qu'il s'agisse d'une seule ou de plusieurs régions, et qui ne sont généralement pas associées à des complications métaboliques. Dans certains cas, il peut s'agir d'une lipohypertrophie (insuline). Ce groupe comprend la lipoatrophie localisée due à la pression, la lipodystrophie localisée induite par les médicaments, la lipodystrophie localisée induite par une panniculite, la lipodystrophie centrifuge et la lipodystrophie localisée idiopathique."},"de":{"name":"Lipodystrophie, lokale","definition":"Eine seltene Gruppe von erworbenen Lipodystrophien, die durch den Verlust von subkutanem Gewebe an meist kleinen Körperregionen gekennzeichnet sind (entweder an einzelnen oder mehreren Stellen) und die typischerweise nicht mit metabolischen Komplikationen einhergehen. In einigen Fällen kann eine Lipohypertrophie (Insulin) auftreten. Zu dieser Gruppe gehören die druckinduzierte lokalisierte Lipoatrophie, die medikamenteninduzierte lokalisierte Lipodystrophie, die Pannikulitis-induzierte lokalisierte Lipodystrophie, die zentrifugale Lipodystrophie und die idiopathische lokalisierte Lipodystrophie."},"es":{"name":"Lipodistrofias localizadas","definition":"Es un grupo poco frecuente de lipodistrofias adquiridas caracterizadas por la pérdida de tejido subcutáneo de regiones generalmente pequeñas del cuerpo, áreas únicas o múltiples, y que por lo general no están asociadas a complicaciones metabólicas. Algunos casos pueden implicar lipohipertrofia (insulina). Este grupo incluye la lipoatrofia localizada inducida por presión, la lipodistrofia localizada inducida por fármacos, la lipodistrofia localizada inducida por paniculitis, la lipodistrofia centrífuga y la lipodistrofia localizada idiopática."},"it":{"name":"Lipodistrofia localizzata","definition":"Si tratta di un gruppo di lipodistrofie acquisite rare, caratterizzate dalla perdita del tessuto sottocutaneo in una o più aree del corpo di piccole dimensioni, di solito non associata a complicanze metaboliche. Alcuni pazienti presentano lipoipertrofia (insulina). Il gruppo comprende la lipoatrofia localizzata indotta dalla pressione, la lipodistrofia localizzata indotta dai farmaci, la lipodistrofia localizzata indotta dalla panniculite, la lipodistrofia centrifuga e la lipodistrofia localizzata idiopatica."},"nl":{"name":"Gelokaliseerde lipodystrofie","definition":"Een zeldzame groep van verworven lipodystrofieën die gekarakteriseerd worden door verlies van onderhuids weefsel in een of meerdere, doorgaans kleine regio's van het lichaam, en die niet typisch geassocieerd zijn met metabole complicaties. In sommige gevallen kan sprake zijn van lipohypertrofie (insuline). Deze groep omvat druk-geïnduceerde gelokaliseerde lipoatrofie, geneesmiddel-geïnduceerde gelokaliseerde lipodystrofie, panniculitis-geïnduceerde gelokaliseerde lipodystrofie, centrifugale lipodystrofie, en idiopathische gelokaliseerde lipodystrofie."},"pt":{"name":"Lipodistrofia localizada"},"pl":{"name":"Lipodystrofia zlokalizowana"},"cs":{"name":"Lokalizovaná forma lipodystrofie"},"uk":{"name":"Локалізована ліподистрофія","definition":"A rare group of acquired lipodystrophies that are characterized by loss of subcutaneous tissue from generally small regions of the body, either single or multiple areas, and are not typically associated with metabolic complications. Some cases may involve lipohypertrophy (insulin). This group includes pressure-induced localized lipoatrophy, drug-induced localized lipodystrophy, panniculitis- induced localized lipodystrophy, centrifugal lipodystrophy, and idiopathic localized lipodystrophy."},"zh":{"name":"局限性脂质营养不良"},"tr":{"name":"Lokalize lipodistrofi"}},"xrefs":[{"source":"MONDO","code":"0019194","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"19194","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4329999","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5867","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10088837","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":98307,"name":"Acquired lipodystrophy","classifications":[187,193]}],"children":[{"orpha":90156,"name":"Centrifugal lipodystrophy","type":"Disease"},{"orpha":90157,"name":"Drug-induced localized lipodystrophy","type":"Disease"},{"orpha":90158,"name":"Idiopathic localized lipodystrophy","type":"Disease"},{"orpha":90159,"name":"Panniculitis-induced localized lipodystrophy","type":"Disease"},{"orpha":90160,"name":"Pressure-induced localized lipoatrophy","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}