{"orpha":781,"name":"Q fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Coxiellosis","Infection due to Coxiella burnetii","Nine Mile fever","Quadrilateral fever","Query fever"],"definition":"Q fever, caused by <i>Coxiella burnetii</i>, is a bacterial zoonosis with a wide clinical spectrum that can be life-threatening and, in some cases, can become chronic.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-781/","orphanet_url":"https://www.orpha.net/en/disease/detail/781","names":{"fr":{"name":"Fièvre Q","synonyms":["Coxiellose","Fièvre du Montana","Fièvre quadrilatérale","Infection à Coxiella burnetii"],"definition":"La fièvre Q, causée par <i>Coxiella burnetii</i> est une zoonose bactérienne à large spectre clinique qui peut mettre en jeu le pronostic vital, et dans certains cas devenir chronique."},"de":{"name":"Q-Fieber","synonyms":["Coxiellose","Infektion durch Coxiella burnetii","Query-Fieber","Schlachthausfieber","Siebentagefieber"],"definition":"Das Q-Fieber ist eine bakterielle Zoonose und wird durch <i>Coxiella burnetii</i> verursacht. Das klinische Spektrum ist breit und reicht von akut lebensbedrohlichen bis zu chronischen Verläufen."},"es":{"name":"Fiebre Q","synonyms":["Coxielosis","Fiebre 'query'","Fiebre cuadrilateral","Fiebre de Nine Mile","Infección por Coxiella burnetii"],"definition":"La fiebre Q, causada por <i>Coxiella burnetii</i>, es una zoonosis bacteriana con un espectro clínico amplio que puede suponer una amenaza para la vida y, en algunos casos, puede llegar a ser crónica."},"it":{"name":"Febbre Q","synonyms":["Coxiellosi","Febbre Query","Febbre di Nine Mile","Febbre quadrilaterale","Infezione da Coxiella burnetii"],"definition":"La febbre Q, da <i>Coxiella burnetii</i>, è una zoonosi batterica associata ad un ampio spettro clinico. Può essere potenzialmente letale e, in alcuni casi, può diventare cronica."},"nl":{"name":"Q-koorts","synonyms":["Coxiellose","Infectie door Coxiella burnetii","Nine Mile koorts","Quadrilaterale koorts","Querykoorts"],"definition":"Q-koorts, veroorzaakt door <i>Coxiella burnetii</i>, is een bacteriële zoönose met een breed klinisch spectrum die levensbedreigend kan zijn en, in sommige gevallen, chronisch kan worden."},"pt":{"name":"Febre Q"},"pl":{"name":"Gorączka Q","synonyms":["Koksielloza","Zakażenie Coxiella burnetii"]},"cs":{"name":"Horečka Q","synonyms":["Koxielóza","Infekce způsobená Coxiellou burnetii","Horečka Nine Mile","Horečka Quadrilateral"]},"uk":{"name":"Q лихоманка","synonyms":["Коксієльоз","Інфекція, спричинена Coxiella burnetii","Лихоманка Девятої милі","Чотирикутна лихоманка","Лихоманка Квері"],"definition":"Q fever, caused by <i>Coxiella burnetii</i>, is a bacterial zoonosis with a wide clinical spectrum that can be life-threatening and, in some cases, can become chronic."},"zh":{"name":"Q热","synonyms":["贝氏柯克斯体所致感染"]},"tr":{"name":"Q ateşi","synonyms":["Coxiellosis","Query ateşi","Nine Mile ateşi","Kuadrilateral ateş","Koksiella burnetii'ye bağlı enfeksiyon"]}},"xrefs":[{"source":"ICD-10","code":"A78","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"DB98.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2113860626"},{"source":"MONDO","code":"0019186","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D011778","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0034362","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7515","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10037688","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.03,"area":"United States","status":"Validated","source":"23535757[PMID]_Center for Diseases Control and Prevention[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.0,"area":"Australia","status":"Validated","source":"16503466[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.4,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.64,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.07,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.18,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-06-17","source":"32629489[PMID]_32310555[PMID]_18755387[PMID]_22226692[PMID]","terms":[{"hpo":"HP:0032252","label":"Granuloma","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003565","label":"Elevated erythrocyte sedimentation rate","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001626","label":"Abnormality of the cardiovascular system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001392","label":"Abnormality of the liver","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0020136","label":"Anticardiolipin IgG antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003613","label":"Antiphospholipid antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001878","label":"Hemolytic anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001433","label":"Hepatosplenomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010702","label":"Increased circulating immunoglobulin concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001511","label":"Intrauterine growth retardation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030166","label":"Night sweats","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033430","label":"Non-infectious meningitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001562","label":"Oligohydramnios","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002923","label":"Rheumatoid factor positive","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002360","label":"Sleep abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001518","label":"Small for gestational age","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003262","label":"Smooth muscle antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002633","label":"Vasculitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005162","label":"Abnormal left ventricular function","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006530","label":"Abnormal pulmonary interstitial morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011034","label":"Amyloidosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001082","label":"Cholecystitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100778","label":"Cryoglobulinemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025343","label":"Lupus anticoagulant","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001698","label":"Pericardial effusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Very rare (<4-1%)","criteria":null}]}}