{"orpha":78,"name":"Ankylostomiasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Ancylostomiasis","Hookworm infection"],"definition":"A hookworm infection caused primarily by the species <i>Ancylostoma duodenale </i> or <i>Necator americanus</i>, usually acquired through penetration of the skin, (often asymptomatic but that can also manifest with an allergic reaction at the site of skin penetration), followed by the migration of larva through the bloodstream to the lungs (causing asymptomatic pneumonitis, eosinophilia) and finally reaching and colonizing the small intestines where they cause blood extravasation leading to diarrhea, abdominal pain, and when untreated, melena, iron-deficiency anemia and protein malnutrition.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-78/","orphanet_url":"https://www.orpha.net/en/disease/detail/78","names":{"fr":{"name":"Ankylostomiase","synonyms":["Ancylostomiase","Ankylostomose"],"definition":"Infection par ankylostome causée principalement par les espèces <i>Ancylostoma duodenale</i> ou <i>Necator americanus</i>, généralement contractée par voie cutanée (souvent asymptomatique, mais une réaction allergique au site de pénétration de la peau est possible), suivie par la migration des larves dans la circulation sanguine jusqu'aux poumons (provoquant une pneumonie asymptomatique, une éosinophilie) pour atteindre et coloniser l'intestin grêle où elles provoquent une extravasation sanguine entraînant des diarrhées, des douleurs abdominales et, en l'absence de traitement, un méléna, une anémie ferriprive et une malnutrition protéique."},"de":{"name":"Ankylostomiasis","synonyms":["Hakenwurm-Infektion"]},"es":{"name":"Anquilostomiasis","synonyms":["Ancilostomiasis","Infección por uncinarias"],"definition":"Es una infección por anquilostomas producida principalmente por la especie <i>Ancylostoma duodenale</i> o <i>Necator americanus</i> que, por lo general, se adquiere a través de la piel, (a menudo asintomática pero que también puede manifestarse con una reacción alérgica en el punto de inoculación), seguida por la migración de la larva a través del torrente sanguíneo hacia los pulmones (provocando neumonitis asintomática, eosinofilia) y alcanzando finalmente el intestino delgado y colonizándolo, donde provocan una extravasación de sangre que conduce a diarrea, dolor abdominal y, en ausencia de tratamiento, melena, anemia por deficiencia de hierro y malnutrición proteica."},"it":{"name":"Anchilostomiasi","synonyms":["Infezione da anchilostomi"],"definition":"L'anchilostomiasi è un'infezione da anchilostoma causata per lo più dalle specie <i>Ancylostoma duodenale</i>, e <i>Necator americanus</i>. Di solito l'infezione avviene attraverso la cute (in genere asintomatica, ma può manifestarsi anche con una reazione allergica nel sito di penetrazione della cute), seguita dalla migrazione delle larve verso i polmoni attraverso il torrente ematico (che esita nella polmonite asintomatica e nell'eosinofilia). Infine, le larve raggiungono e colonizzano l'intestino tenue, causando la fuoriuscita di sangue che esita nella diarrea, nel dolore addominale e, se non trattato, nella melena, nell'anemia da carenza di ferro e nella malnutrizione da carenza di proteine. ."},"nl":{"name":"Ankylostomiasis","synonyms":["Ancylostomiasis","Haakworminfectie"],"definition":"Een infectie met haakwormen die voornamelijk veroorzaakt wordt door de soort <i>Ancylostoma duodenale</i> of <i>Necator americanus</i> en die meestal verworven wordt door penetratie van de huid (vaak asymptomatisch maar kan zich ook manifesteren met een allergische reactie op de plaats waar de huid werd gepenetreerd), gevolgd door migratie van larven door de bloedstroom naar de longen waar ze asymptomatische pneumonitis en eosinofilie veroorzaken, om uiteindelijk de dunne darm te bereiken en te koloniseren waar ze bloeduitstorting veroorzaken, wat leidt tot diarree, abdominale pijn, en indien behandeling uitblijft, zwarte stoelgang, ijzergebreksanemie, en malnutritie van proteïne."},"pt":{"name":"Ancilostomiose","synonyms":["Infeção por vermes com ganchos"]},"pl":{"name":"Ankilostomatoza","synonyms":["Zakażenie tęgoryjcami"]},"cs":{"name":"Ankylostomiáza","synonyms":["Infekce měchovcem"]},"uk":{"name":"Анкілостомоз","synonyms":["Анцилостомоз","Зараження аскаридами"],"definition":"A hookworm infection caused primarily by the species <i>Ancylostoma duodenale </i> or <i>Necator americanus</i>, usually acquired through penetration of the skin, (often asymptomatic but that can also manifest with an allergic reaction at the site of skin penetration), followed by the migration of larva through the bloodstream to the lungs (causing asymptomatic pneumonitis, eosinophilia) and finally reaching and colonizing the small intestines where they cause blood extravasation leading to diarrhea, abdominal pain, and when untreated, melena, iron-deficiency anemia and protein malnutrition."},"zh":{"name":"钩虫病","synonyms":["钩虫感染"]},"tr":{"name":"Ankilostomiaz","synonyms":["Ansilostomiyaz","Kanca kurdu enfeksiyonu"]}},"xrefs":[{"source":"ICD-10","code":"B76.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B76.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B76.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B76.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F68.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1542252776"},{"source":"MONDO","code":"0005645","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000724","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0002831","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9742","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10002255","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}