{"orpha":770,"name":"Rabies","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Rabies is a viral zoonosis leading to a fatal encephalopathy if not treated.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-770/","orphanet_url":"https://www.orpha.net/en/disease/detail/770","names":{"fr":{"name":"Rage","definition":"La rage est une zoonose virale responsable d'encéphalopathie en l'absence de traitement."},"de":{"name":"Tollwut","synonyms":["Rabies"],"definition":"Die Tollwut ist eine virale Zoonose, die unbehandelt zu fataler Enzephalopathie führt."},"es":{"name":"Rabia","definition":"La rabia es una zoonosis vírica que conduce a una encefalopatía fatal si no es tratada."},"it":{"name":"Rabbia","definition":"La rabbia è una zoonosi virale che, in assenza di trattamento, esita in un'encefalopatia fatale."},"nl":{"name":"Rabiës","synonyms":["Hondsdolheid"],"definition":"Rabiës is een virale zoönose die zonder behandeling leidt tot fatale encefalopathie."},"pt":{"name":"Raiva","definition":"A raiva é uma zoonose viral que leva a uma encefalopatia fatal se não for tratada."},"pl":{"name":"Wścieklizna"},"cs":{"name":"Vzteklina","synonyms":["Rabies","Lyssa"]},"uk":{"name":"Сказ","definition":"Rabies is a viral zoonosis leading to a fatal encephalopathy if not treated."},"zh":{"name":"狂犬病"},"tr":{"name":"Kuduz"}},"xrefs":[{"source":"ICD-10","code":"A82.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A82.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A82.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C82","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"854762584"},{"source":"MONDO","code":"0019173","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D011818","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0034494","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7516","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10037742","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98010,"name":"Infectious disease of the nervous system","classifications":[181]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"[EXPERT]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"United States","status":"Not yet validated","source":"22699971[PMID]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002039","label":"Anorexia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007018","label":"Attention deficit hyperactivity disorder","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003781","label":"Excessive salivation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002076","label":"Migraine","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100776","label":"Recurrent pharyngitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001604","label":"Vocal cord paresis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001645","label":"Sudden cardiac death","frequency":"Occasional (29-5%)","criteria":null}]}}