{"orpha":730421,"name":"Complex neurodevelopmental disorder with unspecific dysmorphic features/congenital anomalies without intellectual disability or autism spectrum disorder","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare neurodevelopmental disorder characterized by the combination of at least two neurodevelopmental disorders, including specific learning disorder (e.g., impairment in reading, written expression, or mathematics), motor disorder (e.g. developmental coordination disorder, stereotypic movement disorder, tic disorder), communication disorder (e.g., developmental language disorder, speech sound disorder, childhood-onset fluency disorder, social/pragmatic communication disorder), attention deficit/hyperactivity disorder (ADD/ADHD) and other specified or unspecified neurodevelopmental disorders as defined in DSM-5 or ICD-11. Patients don't reach the criteria of an autism spectrum disorder diagnosis, do not have intellectual disability but can present with unspecific dysmorphic features and/or congenital anomalies.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-730421/","orphanet_url":"https://www.orpha.net/en/disease/detail/730421","names":{"fr":{"name":"Trouble complexe du neurodéveloppement avec anomalies congénitales multiples/dysmorphie sans déficience intellectuelle ni trouble du spectre autistique"},"de":{"name":"Komplexe neurologische Entwicklungsstörung mit unspez. dysmorphen Merkmalen/kongenitalen Anomalien ohne Intelligenzminderung oder Autismus-Spektrum-Störung"},"es":{"name":"Trastorno del neurodesarrollo complejo con rasgos dismórficos inespecíficos/anomalías congénitas sin discapacidad intelectual ni trastorno del espectro autista"},"it":{"name":"Malattia complessa del neurosviluppo con dismorfismi aspecifici/anomalie congenite senza disabilità intellettiva o disturbi dello spettro autistico"},"nl":{"name":"Complexe NDD met aspecifieke dysmorfe kenmerken/congenitale anomalieën zonder intellectuele achterstand of autismespectrumstoornis"},"pt":{"name":"Complex neurodevelopmental disorder with unspesific dysmorphic features/congenital anomalies without intellectual disability or autism spectrum disorder"},"pl":{"name":"Complex neurodevelopmental disorder with unspecific dysmorphic features/congenital anomalies without intellectual disability or autism spectrum disorder"},"cs":{"name":"Complex neurodevelopmental disorder with unspecific dysmorphic features/congenital anomalies without intellectual disability or autism spectrum disorder"}},"xrefs":[],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":730693,"name":"Rare complex neurodevelopmental disorder without intellectual disability or autism spectrum disorder","classifications":[156,181]},{"orpha":93890,"name":"Rare developmental defect during embryogenesis","classifications":[147]},{"orpha":183530,"name":"Rare genetic developmental defect during embryogenesis","classifications":[156]}],"children":[{"orpha":730418,"name":"Complex neurodevelopmental disorder with unspecific dysmorphic features/congenital anomalies without ID/ASD of genetic/genomic origin","type":"Etiological subtype"},{"orpha":730415,"name":"Complex neurodevelopmental disorder with unspecific dysmorphic features/congenital anomalies without ID/ASD of not yet identified genetic/genomic cause","type":"Etiological subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}