{"orpha":730396,"name":"Invasive meningococcal disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["IMD"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-730396/","orphanet_url":"https://www.orpha.net/en/disease/detail/730396","names":{"fr":{"name":"Infection invasive à méningocoque","synonyms":["IIM"]},"de":{"name":"Invasive Meningokokkenerkrankung","synonyms":["IMD"]},"es":{"name":"Enfermedad meningocócica invasiva","synonyms":["EMI"]},"it":{"name":"Malattia meningococcica invasiva","synonyms":["IMD"]},"nl":{"name":"Invasieve meningokokkenziekte","synonyms":["Invasieve infectie door Neisseria meningitidis","IMD","Invasieve meningokokkeninfectie"]},"pt":{"name":"Invasive meningococcal disease"},"pl":{"name":"Invasive meningococcal disease","synonyms":["IMD"]},"cs":{"name":"Invasive meningococcal disease","synonyms":["IMD"]}},"xrefs":[],"associations":[],"incoming_associations":[{"type":"Moved to","orpha":33475,"name":"Meningococcal meningitis","status":"inactive"}],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-02-07","source":"30860561[PMID]_31990941[PMID]_31956973[PMID]_29203096[PMID]","terms":[{"hpo":"HP:0012229","label":"CSF pleocytosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011972","label":"Hypoglycorrhachia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0031179","label":"Nuchal rigidity","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000967","label":"Petechiae","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002587","label":"Projectile vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:6000647","label":"Bulging fontanelle","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002329","label":"Drowsiness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000365","label":"Hearing impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032308","label":"Increased circulating procalcitonin concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002516","label":"Increased intracranial pressure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001085","label":"Papilledema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011880","label":"Acute disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002045","label":"Hypothermia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002643","label":"Neonatal respiratory distress","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Very rare (<4-1%)","criteria":null}]}}