{"orpha":715950,"name":"Diffuse hemispheric glioma-H3 G34-mutant","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-715950/","orphanet_url":"https://www.orpha.net/en/disease/detail/715950","names":{"fr":{"name":"Gliome diffus hémisphérique H3 G34-muté"},"de":{"name":"Diffuses hemisphärisches Gliom, H3 G34-Mutante"},"es":{"name":"Glioma hemisférico difuso con mutación H3 G34"},"it":{"name":"Glioma emisferico diffuso con mutazione H3 G34"},"nl":{"name":"Diffuus hemisferisch glioom-H3 G34-mutant"},"pt":{"name":"Diffuse hemispheric glioma-H3 G34-mutant"},"pl":{"name":"Rozlany glejak półkulowy - mutacja H3 G34"},"cs":{"name":"Diffuse hemispheric glioma-H3 G34-mutant"}},"xrefs":[{"source":"ICD-10","code":"C71.9","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A00.0Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"XH2SS9","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"315967029"}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":251561,"name":"High-grade astrocytoma","classifications":[181,202]}],"children":[],"genes":[{"symbol":"H3-3A","name":"H3.3 histone A","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"40402198[PMID]_36493960[PMID]","hgnc":"4764","ensembl":"ENSG00000163041","omim":"601128","loci":["1q42.12"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}