{"orpha":70475,"name":"Radiation proctitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Radiation proctitis is a rare rectal disease directly induced by pelvic radiotherapy and characterized by rectal bleeding, change in bowel habits, tenesmus and sepsis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-70475/","orphanet_url":"https://www.orpha.net/en/disease/detail/70475","names":{"fr":{"name":"Proctite radique","definition":"La proctite radique est une maladie rectale rare causée par une radiothérapie pelvienne, caractérisée par un saignement rectal, une modification de la fréquence des selles, un ténesme et une septicémie."},"de":{"name":"Radiogene Proktitis","synonyms":["Strahlenproktitis"],"definition":"Die Strahlenproktitis ist eine seltene Erkrankung des Rektums. Sie wird direkt durch Strahlentherapie im Bereich des Beckens ausgelöst und ist gekennzeichnet durch rektale Blutungen, veränderte Gewohnheiten beim Stuhlgang, Tenesmen und Sepsis."},"es":{"name":"Proctitis por radiación","definition":"La proctitis por radiación es una enfermedad rectal poco común provocada directamente por una radioterapia pélvica y que se caracteriza por sangrado rectal, cambios en los hábitos de evacuación, tenesmo y sepsis."},"it":{"name":"Proctite da radiazioni","definition":"La proctite da radiazioni è una malattia rara del retto, provocata dalla radioterapia a livello della regione pelvica, caratterizzata da sanguinamento rettale, alterazione delle abitudini intestinali, tenesmo e sepsi."},"nl":{"name":"Radiatieproctitis","synonyms":["Bestralingsproctitis","Proctitis door straling"],"definition":"Een zeldzame aandoening van rectum, rechtstreeks geïnduceerd door radiotherapie van bekken, en gekenmerkt door rectaal bloedverlies, verandering van ontlastingspatroon, tenesmus en sepsis."},"pt":{"name":"Proctite por radiação"},"pl":{"name":"Popromienne zapalenie prostnicy"},"cs":{"name":"Radiační proktitida"},"uk":{"name":"Променевий проктит","definition":"Radiation proctitis is a rare rectal disease directly induced by pelvic radiotherapy and characterized by rectal bleeding, change in bowel habits, tenesmus and sepsis."},"zh":{"name":"放射性直肠炎"},"tr":{"name":"Radyasyon proktit"}},"xrefs":[{"source":"ICD-10","code":"K62.7","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"DB33.42","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"177305885"},{"source":"MONDO","code":"0019084","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0400827","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10037766","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":521132,"name":"Radiation-induced disorder","classifications":[204]},{"orpha":117569,"name":"Rare intestinal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":35.0,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-17","source":"27504391[PMID]_36660465[PMID]","terms":[{"hpo":"HP:0025015","label":"Abnormal vascular morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003549","label":"Abnormality of connective tissue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004296","label":"Abnormality of gastrointestinal vasculature","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002034","label":"Abnormality of the rectum","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002597","label":"Abnormality of the vasculature","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002583","label":"Colitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0005224","label":"Rectal abscess","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100590","label":"Rectal fistula","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0500005","label":"Anal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100279","label":"Ulcerative colitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012089","label":"Arteritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005214","label":"Intestinal obstruction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012702","label":"Tenesmus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002607","label":"Bowel incontinence","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002573","label":"Hematochezia","frequency":"Very rare (<4-1%)","criteria":null}]}}