{"orpha":700,"name":"Alopecia totalis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A form of alopecia areata, an inflammatory disease of the hair follicle, characterized by a complete loss of hair of the entire scalp which becomes glabrous.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-700/","orphanet_url":"https://www.orpha.net/en/disease/detail/700","names":{"fr":{"name":"Pelade totale","definition":"La pelade totale est une forme d'alopécie en aires, une maladie inflammatoire du follicule pileux, caractérisée par une alopécie complète du cuir chevelu qui devient glabre."},"de":{"name":"Alopecia totalis","definition":"Die Alopecia totalis ist eine Form der Alopecia areata, einer entzündlichen Erkrankung des Haarfollikels, und gekennzeichnet durch Haarverlust an der Kopfhaut, bis zu vollständiger Haarlosigkeit."},"es":{"name":"Alopecia total","definition":"Es una forma de alopecia areata, una enfermedad inflamatoria del folículo del pelo, que se caracteriza por una pérdida completa del pelo de todo el cuero cabelludo que pasa a ser glabro."},"it":{"name":"Alopecia areata totale","definition":"L'alopecia totale è una forma di alopecia areata, una malattia infiammatoria del follicolo pilifero, caratterizzata dalla perdita completa dei capelli del cuoio capelluto, che diventa glabro."},"nl":{"name":"Alopecia totalis","definition":"Een vorm van alopecia areata, een inflammatoire ziekte van haarfollikels, gekarakteriseerd door volledig verlies van haar op de hele hoofdhuid die kaal wordt."},"pt":{"name":"Alopecia totalis"},"pl":{"name":"Łysienie całkowite"},"cs":{"name":"Alopecia totalis"},"uk":{"name":"Тотальна алопеція","definition":"A form of alopecia areata, an inflammatory disease of the hair follicle, characterized by a complete loss of hair of the entire scalp which becomes glabrous."},"zh":{"name":"全秃"},"tr":{"name":"Alopesi totalis"}},"xrefs":[{"source":"OMIM","code":"104000","qualifier":"NTBT","icd_relation":null,"validated":true},{"source":"OMIM","code":"300042","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"OMIM","code":"610753","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"L63.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"ED70.21","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1633035058"},{"source":"MONDO","code":"0019080","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0263504","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"1470","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10001766","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":79364,"name":"Alopecia","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.5,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-09-18","source":"33085372[PMID]","terms":[{"hpo":"HP:0002293","label":"Alopecia of scalp","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007418","label":"Alopecia totalis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001808","label":"Fragile nails","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002037","label":"Inflammation of the large intestine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001803","label":"Nail pits","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001806","label":"Onycholysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030804","label":"Trachyonychia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100651","label":"Type I diabetes mellitus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001045","label":"Vitiligo","frequency":"Occasional (29-5%)","criteria":null}]}}