{"orpha":687741,"name":"Multisystem Langerhans cell histiocytosis","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Multisystem Langerhans cell granulomatosis","Multisystem histiocytosis X"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-687741/","orphanet_url":"https://www.orpha.net/en/disease/detail/687741","names":{"fr":{"name":"Histiocytose langerhansienne multisystémique","synonyms":["Granulomatose à cellules de Langerhans multisystémique","Histiocytose X multisystémique"]},"de":{"name":"Langerhans-Zell-Histiozytose, multisystemische","synonyms":["Histiozytose X, multisystemische","Langerhans-Zell-Granulomatose, multisystemische"]},"es":{"name":"Histiocitosis de células de Langerhans multisistémica","synonyms":["Granulomatosis de células de Langerhans multisistémica","Histiocitosis X multisistémica"]},"it":{"name":"Multisystem Langerhans cell histiocytosis"},"nl":{"name":"Multisystemische langerhanscelhistiocytose","synonyms":["Multisystemische histiocytose X","Multisystemische langerhanscelgranulomatose"]},"pt":{"name":"Histiocitose de células Langerhans multissistémica","synonyms":["Granulomatose de células Langerhans multissistémica","Histiocitose X multissistémica"]},"pl":{"name":"Multisystem Langerhans cell histiocytosis","synonyms":["Multisystem Langerhans cell granulomatosis","Multisystem histiocytosis X"]},"cs":{"name":"Multisystémová histiocytóza z Langerhansových buněk","synonyms":["Multisystem Langerhans cell granulomatosis","Multisystem histiocytosis X"]}},"xrefs":[{"source":"ICD-10","code":"C96.0","qualifier":"NTBT","icd_relation":"attributed","validated":false}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":389,"name":"Langerhans cell histiocytosis","classifications":[184,194,196,202,233]}],"children":[],"genes":[{"symbol":"BRAF","name":"B-Raf proto-oncogene, serine/threonine kinase","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"22996177[PMID]","hgnc":"1097","ensembl":"ENSG00000157764","omim":"164757","loci":["7q34"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}