{"orpha":685082,"name":"Pediatric acute respiratory distress syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["PARDS","Pediatric ARDS"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-685082/","orphanet_url":"https://www.orpha.net/en/disease/detail/685082","names":{"fr":{"name":"Syndrome de détresse respiratoire aiguë de l'enfant","synonyms":["SDRA de l'enfant"]},"de":{"name":"Akutes pädiatrisches Atemnotsyndrom","synonyms":["ARDS im Kindesalter","Akutes nicht obstruktives Lungenversagen im Kindesalter","PARDS","Pädiatrisches ARDS"]},"es":{"name":"Síndrome de dificultad respiratoria aguda pediátrica","synonyms":["PARDS","SDRA pediátrico"]},"it":{"name":"Sindrome pediatrica da distress respiratorio acuto","synonyms":["PARDS","PARDS pediatrica"]},"nl":{"name":"Pediatrisch acuut ademhalingsnoodsyndroom","synonyms":["PARDS","Pediatrisch ARDS","Pediatrisch acute respiratory distress-syndroom"]},"pt":{"name":"Síndrome pediátrico de dificuldade respiratória aguda","synonyms":["ARDS pediátrico","PARDS"]},"pl":{"name":"Pediatric acute respiratory distress syndrome","synonyms":["PARDS","Pediatric ARDS"]},"cs":{"name":"Syndrom akutní dechové tísně u dětí","synonyms":["PARDS","Pediatric ARDS"]}},"xrefs":[{"source":"ICD-11","code":"CB00","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"100131","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Moved to","orpha":70587,"name":"Infant acute respiratory distress syndrome","status":"inactive"}],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]}],"children":[],"genes":[{"symbol":"ABCA3","name":"ATP binding cassette subfamily A member 3","gene_type":"gene with protein product","association":"Candidate gene tested in","status":"Not yet assessed","source":"27516224[PMID]","hgnc":"33","ensembl":"ENSG00000167972","omim":"601615","loci":["16p13.3"]},{"symbol":"SFTPB","name":"surfactant protein B","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"11063734[PMID]","hgnc":"10801","ensembl":"ENSG00000168878","omim":"178640","loci":["2p11.2"]},{"symbol":"SFTPC","name":"surfactant protein C","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"29805340[PMID]","hgnc":"10802","ensembl":"ENSG00000168484","omim":"178620","loci":["8p21.3"]}],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":[],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-18","source":"10762543[PMID]_28589372[PMID]_30379667[PMID]","terms":[{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000765","label":"Abnormal thorax morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100750","label":"Atelectasis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000961","label":"Cyanosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030863","label":"Nasal flaring","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001695","label":"Cardiac arrest","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011947","label":"Respiratory tract infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Very rare (<4-1%)","criteria":null}]}}