{"orpha":673,"name":"Malaria","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A life-threatening parasitic disease caused by <i>Plasmodium</i> (<i>P. </i>) parasites that are transmitted by <i>Anophles</i> mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-673/","orphanet_url":"https://www.orpha.net/en/disease/detail/673","names":{"fr":{"name":"Paludisme","synonyms":["Malaria"],"definition":"Une maladie parasitaire mettant en jeu le pronostic vital, causée par les parasites <i>Plasmodium (P.)</i>, et transmise à l'homme par la morsure du moustique <i>Anophles</i>. Sur le plan clinique, elle se caractérise par des épisodes fiévreux, des céphalées, des frissons et des vomissements."},"de":{"name":"Malaria","definition":"Eine lebensbedrohliche parasitäre Erkrankung, verursacht durch Infektion mit verschiedenen Arten von Protozoen der Gattung <i>Plasmodium</i>. Sie wird durch Stiche der <i>Anophles</i>-Mücke auf den Menschen übertragen werden und ist klinisch typischerweise durch Fieberanfälle, Kopfschmerzen, Schüttelfrost und Erbrechen gekennzeichnet."},"es":{"name":"Malaria","synonyms":["Paludismo"],"definition":"Es una enfermedad parasitaria potencialmente mortal causada por parásitos <i>Plasmodium</i> (<i> P. </i>) transmitidos a humanos por picaduras del mosquito <i>Anopheles</i>. Por lo general, está clínicamente caracterizada por episodios de fiebre, cefalea, escalofríos y vómitos."},"it":{"name":"Malaria"},"nl":{"name":"Malaria","definition":"Een levensbedreigende parasitaire ziekte, veroorzaakt door <i>Plasmodium</i> (<i>P. </i>)-parasieten die op mensen worden overgedragen door een beet van een <i>Anophles</i>-mug, en doorgaans klinisch gekarakteriseerd door aanvallen van koorts, hoofdpijn, koude rillingen en braken."},"pt":{"name":"Malária"},"pl":{"name":"Malaria"},"cs":{"name":"Malárie"},"uk":{"name":"Малярія","definition":"A life-threatening parasitic disease caused by <i>Plasmodium</i> (<i>P. </i>) parasites that are transmitted by <i>Anophles</i> mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting."},"zh":{"name":"疟疾"},"tr":{"name":"Sıtma"}},"xrefs":[{"source":"OMIM","code":"611162","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"B50.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B50.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B50.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B51.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B51.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B51.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B52.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B52.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B52.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B53.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B53.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B53.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B54","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F40","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"579583286"},{"source":"ICD-11","code":"1F41","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1203794080"},{"source":"ICD-11","code":"1F42","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"862789727"},{"source":"ICD-11","code":"1F43","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1168452782"},{"source":"ICD-11","code":"1F44","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1260563068"},{"source":"ICD-11","code":"1F45","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"633896543"},{"source":"MONDO","code":"0005136","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008288","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0024530","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6961","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10025487","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":3.0,"area":"Europe","status":"Validated","source":"European Medicines Agency2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":12.0,"area":"France","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"6-9 / 10 000","value":73.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.2,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.8,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.1,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.52,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.74,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.68,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.7,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.18,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.84,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.54,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.84,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.44,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.28,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.5,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.88,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.38,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.62,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.62,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.75,"area":"Iceland","status":"Validated","source":"European Centre for Disease prevention and Control 2016-2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-01-25","source":"27175507[PMID]","terms":[{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002011","label":"Morphological central nervous system abnormality","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001871","label":"Abnormality of blood and blood-forming tissues","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100543","label":"Cognitive impairment","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002141","label":"Gait imbalance","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002904","label":"Hyperbilirubinemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000488","label":"Retinopathy","frequency":"Occasional (29-5%)","criteria":null}]}}