{"orpha":67,"name":"Amoebiasis due to Entamoeba histolytica","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A parasitic disease caused by the protozoa, <i>Entamoeba histolytica</i>, mainly occurring in tropical regions after the ingestion of an amoebic cyst, and resulting in clinical manifestations that may range from an asymptomatic state to amoebic colitis (violent abdominal pain, a painful contracted feeling around the anal sphincter, blood and mucus in the stools but without the presence of fever), or amoebic liver abscesses (fever, chills, abdominal pain, weight loss, hepatomegaly) that can be fatal if not immediately treated. Extraintestinal involvement elsewhere (i.e. thoracic, hepatic) is extremely rare.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-67/","orphanet_url":"https://www.orpha.net/en/disease/detail/67","names":{"fr":{"name":"Amibiase à Entamoeba histolytica","definition":"Une maladie parasitaire causée par le protozoaire <i>Entamoeba histolytica</i>, survenant surtout dans les régions tropicales après ingestion d'un kyste amoebien. Les manifestations cliniques peuvent varier d'un état asymptomatique à une colite amoebienne (une douleur abdominale violente, une sensation douloureuse de contraction autour du sphincter anal, présence de sang et de mucus dans les selles, en l'absence de fièvre), ou à des abcès hépatiques amoebiens (fièvre, frissons, douleur abdominale, perte de poids, hépatomégalie), pouvant être fatals s'ils ne sont pas traités immédiatement. L'atteinte extra-intestinale (thoracique, hépatique) est extrêmement rare."},"de":{"name":"Amöbiasis durch Entamoeba histolytica"},"es":{"name":"Amebiasis por Entamoeba histolytica","definition":"Es una enfermedad parasitaria causada por el protozoo <i>Entamoeba histolytica</i> que se presenta principalmente en regiones tropicales después de la ingestión de un quiste amebiano dando lugar a manifestaciones clínicas que pueden ir desde un estado asintomático hasta colitis amebiana (dolor abdominal intenso, sensación dolorosa de contracción alrededor del esfínter anal, sangre y mucosidad en las heces, pero sin fiebre) o abscesos hepáticos amebianos (fiebre, escalofríos, dolor abdominal, pérdida de peso, hepatomegalia) que puede ser fatal si no se trata de inmediato. La afectación extraintestinal (torácica, hepática) es muy infrecuente."},"it":{"name":"Amebiasi da Entamoeba histolytica","definition":"L'amebiasi da Entamoeba histolytica è una parassitosi causata dal protozoo Entamoeba histolytica, presente soprattutto nelle regioni tropicali. È causata dall'ingestione di una cisti amebica; i pazienti possono essere asintomatici oppure presentare colite amebica (forte dolore addominale, sensazione di contrazioni dolorose attorno allo sfintere anale, presenza di sangue e muco nelle feci, in assenza di febbre) o ascessi epatici amebici (febbre, brividi, dolore addominale, perdita di peso, epatomegalia), che possono essere letali se non trattati tempestivamente. L'interessamento extraintestinale (torace, fegato) è molto raro."},"nl":{"name":"Amoebiase door Entamoeba histolytica","synonyms":["Amoebiasis door Entamoeba histolytica"],"definition":"Een parasitaire ziekte veroorzaakt door het Protozoön <i>Entamoeba histolytica</i>, die voornamelijk voorkomt in tropische gebieden na inname van een amoebische cyste, en die leidt tot klinische manifestaties gaande van een asymptomatische toestand tot amoebische colitis (hevige buikpijn, een pijnlijk samentrekkend gevoel rond de anale sluitspier, bloed en mucus in de stoelgang maar zonder aanwezigheid van koorts), of amoebische leverabcessen (koorts, koude rillingen, buikpijn, gewichtsverlies, hepatomegalie) die fataal kunnen zijn indien onmiddellijke behandeling uitblijft. Overige extra-intestinale betrokkenheid (i.e. thoracaal, hepatisch) is uiterst zeldzaam."},"pt":{"name":"Amebiose por Entamoeba histolytica"},"pl":{"name":"Pełzakowica wywołana Entamoeba histolytica"},"cs":{"name":"Amébiáza způsobená Entamoeba histolytica"},"uk":{"name":"Амебіаз, спричинений Entamoeba histolytica","definition":"A parasitic disease caused by the protozoa, <i>Entamoeba histolytica</i>, mainly occurring in tropical regions after the ingestion of an amoebic cyst, and resulting in clinical manifestations that may range from an asymptomatic state to amoebic colitis (violent abdominal pain, a painful contracted feeling around the anal sphincter, blood and mucus in the stools but without the presence of fever), or amoebic liver abscesses (fever, chills, abdominal pain, weight loss, hepatomegaly) that can be fatal if not immediately treated. Extraintestinal involvement elsewhere (i.e. thoracic, hepatic) is extremely rare."},"zh":{"name":"溶组织内阿米巴所致阿米巴病"},"tr":{"name":"Entamoeba histolytica -ilişkili amipiyaz"}},"xrefs":[{"source":"ICD-10","code":"A06.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.4","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.5","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.6","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.7","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A06.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1A36","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"435671752"},{"source":"ICD-11","code":"1A36.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1727029934"},{"source":"ICD-11","code":"1A36.00","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1616956984"},{"source":"ICD-11","code":"1A36.01","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"349019849"},{"source":"ICD-11","code":"1A36.10","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1730350429"},{"source":"MONDO","code":"0019028","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C531613","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2930799","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-09","source":"30631758[PMID]_30255429[PMID]_25101557[PMID]_9504344[PMID]","terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025085","label":"Bloody diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002579","label":"Gastrointestinal dysmotility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004385","label":"Protracted diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001697","label":"Abnormal pericardium morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032016","label":"Abnormal sputum","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100282","label":"Acute colitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002563","label":"Constrictive pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002625","label":"Deep venous thrombosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003155","label":"Elevated circulating alkaline phosphatase concentration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003073","label":"Hypoalbuminemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005214","label":"Intestinal obstruction","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100523","label":"Liver abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025044","label":"Lung abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011919","label":"Pleural empyema","frequency":"Very rare (<4-1%)","criteria":null}]}}