{"orpha":664372,"name":"Soft and hard cleft palate","type":"Morphological anomaly","group":"Disorder","status":"active","flags":[],"synonyms":["Combined form of soft and hard cleft palate","Isolated cleft of the soft and hard palate"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-664372/","orphanet_url":"https://www.orpha.net/en/disease/detail/664372","names":{"fr":{"name":"Fente vélo-palatine"},"de":{"name":"Hart- und Weichgaumenspalte","synonyms":["Isolierte Spaltbildung des weichen und harten Gaumens","Kombinierte Form der weichen und harten Gaumenspalte"]},"es":{"name":"Hendidura del paladar blando y duro","synonyms":["Forma combinada de paladar hendido blando y duro","Hendidura aislada del paladar blando y duro"]},"it":{"name":"Schisi del palato molle e duro","synonyms":["Forma combinata di schisi del palato molle e duro","Schisi isolata del palato molle e duro"]},"nl":{"name":"Gespleten zacht en hard gehemelte","synonyms":["Schisis van palatum molle en palatum durum","Gecombineerde vorm van gespleten zacht en hard gehemelte","Geïsoleerde spleet van zacht en hard gehemelte"]},"pt":{"name":"Fenda palato mole e duro","synonyms":["Fenda isolada do palato mole e duro","Forma combinada de fenda do palato mole e duro"]},"pl":{"name":"Rozszczep podniebienia miękkiego i twardego","synonyms":["Combined form of soft and hard cleft palate","Isolated cleft of the soft and hard palate"]},"cs":{"name":"Rozštěp měkkého a tvrdého patra","synonyms":["Combined form of soft and hard cleft palate","Isolated cleft of the soft and hard palate"]},"uk":{"name":"Розщілина мякого та твердого піднебіння","synonyms":["Комбінована форма розщілини мякого та твердого піднебіння","Ізольована розщілина мякого та твердого піднебіння"]}},"xrefs":[{"source":"ICD-10","code":"Q35.5","qualifier":"E","icd_relation":"specific","validated":true},{"source":"MONDO","code":"0971092","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"971092","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":2014,"name":"Cleft palate","classifications":[147,209]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":[],"prevalence":[],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-07-09","source":"37436176[PMID]_33976983[PMID]","terms":[{"hpo":"HP:0000689","label":"Dental malocclusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001611","label":"Hypernasal speech","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000327","label":"Hypoplasia of the maxilla","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000347","label":"Micrognathia","frequency":"Occasional (29-5%)","criteria":null}]}}