{"orpha":647758,"name":"Adrenal Cushing syndrome","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["Adrenal CS"],"definition":"A group of endogenous Cushing syndrome (CS) that may result from excess secretion of cortisol by either a unilateral and benign (adrenocortical adenoma), or malignant (adrenocortical carcinoma) adrenocortical tumor, or nodular adrenocortical disease, including Cushing syndrome due to bilateral macronodular adrenocortical disease (BMAD), isolated micronodular adrenocortical disease (i-MAD) and primary pigmented nodular adrenocortical disease (PPNAD; isolated or in Carney complex).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-647758/","orphanet_url":"https://www.orpha.net/en/disease/detail/647758","names":{"fr":{"name":"Syndrome de Cushing surrénalien","definition":"Groupe de syndromes de Cushing endogènes pouvant résulter d'une sécrétion excessive de cortisol par une tumeur surrénalienne unilatérale bénigne (adénome surrénalien) ou maligne (carcinome surrénalien), ou une maladie nodulaire surrénalienne, y compris le syndrome de Cushing dû à une maladie macronodulaire bilatérale des surrénales (BMAD), une maladie micronodulaire des glandes surrénales isolée (i-MAD) et une maladie nodulaire pigmentée primaire de la surrénale (PPNAD ; isolée ou associée au complexe de Carney)."},"de":{"name":"Adrenales Cushing-Syndrom","synonyms":["Adrenales CS"],"definition":"Eine Gruppe von endogenen Cushing-Syndromen (CS), die aus einer übermäßigen Sekretion von Cortisol durch einen einseitigen und gutartigen (adrenokortikales Adenom) oder malignen (adrenokortikales Karzinom) adrenokortikalen Tumor resultieren können, oder einer knotigen Nebennierenrindenerkrankung, einschließlich des Cushing-Syndroms aufgrund einer bilateralen makronodulären Nebennierenrindenerkrankung (BMAD), einer isolierten mikronodulären Nebennierenrindenerkrankung (i-MAD) und einer primären pigmentierten nodulären Nebennierenrindenerkrankung (PPNAD; isoliert oder im Carney-Komplex)."},"es":{"name":"Síndrome de Cushing suprarrenal","synonyms":["SC suprarrenal"],"definition":"Es un grupo del síndrome de Cushing (SC) endógeno que puede resultar de una secreción excesiva de cortisol por un tumor adrenocortical unilateral y benigno (adenoma adrenocortical), o maligno (carcinoma adrenocortical), o enfermedad adrenocortical nodular, incluyendo el síndrome de Cushing por enfermedad adrenocortical macronodular bilateral (BMAD), enfermedad adrenocortical micronodular aislada (i-MAD) y enfermedad adrenocortical nodular pigmentada primaria (PPNAD; aislada o en el complejo de Carney)."},"it":{"name":"Sindrome di Cushing surrenalica","synonyms":["SC surrenalica"]},"nl":{"name":"Adrenaal syndroom van Cushing","synonyms":["Adrenaal CS","Syndroom van Cushing met oorzaak in bijnier"],"definition":"Een groep van endogeen syndroom van Cushing (CS), mogelijk veroorzaakt door excessieve secretie van cortisol door een unilaterale en goedaardige (bijnierschorsadenoom) of kwaadaardige (bijnierschorscarcinoom) bijnierschorstumor, of door nodulaire adrenocorticale ziekte, waaronder syndroom van Cushing door bilaterale macronodulaire adrenocorticale ziekte (BMAD), geïsoleerde micronodulaire adrenocorticale ziekte (i-MAD) en primaire gepigmenteerde nodulaire adrenocorticale ziekte (PPNAD; geïsoleerd of als onderdeel van Carney-complex)."},"pt":{"name":"Síndrome Cushing supra-renal","synonyms":["CS supra-renal"],"definition":"Grupo da síndrome Cushing (SC) endógena que pode resultar da secreção excessiva de cortisol por um tumor adrenocortical unilateral e benigno (adenoma adrenocortical) ou maligno (carcinoma adrenocortical) ou doença adrenocortical nodular, incluindo a síndrome Cushing devido à doença adrenocortical macronodular bilateral (DMBA), doença adrenocortical micronodular isolada (DMI-i) e doença adrenocortical nodular pigmentada primária (DPPNAD; isolada ou no complexo Carney)."},"pl":{"name":"Zespół Cushinga pochodzenia nadnerczowego","synonyms":["Adrenal CS"],"definition":"Grupa endogennego zespołu Cushinga, który może wynikać z nadmiernego wydzielania kortyzolu przez jednostronny i łagodny guz kory nadnerczy (gruczolak kory nadnerczy lub złośliwy rak kory nadnerczy) lub guzkowy rozrost kory nadnerczy. Zalicza się tu również zespół Cushinga spowodowany obustronnym makroguzkowym rozrostem kory nadnerczy, izolowanym mikroguzkowym rozrostem kory nadnerczy oraz pierwotnym pigmentowym guzkowym rozrostem kory nadnerczy (izolowanym lub w zespole Carneya)."},"cs":{"name":"Adrenální Cushingův syndrom","synonyms":["Adrenal CS"]},"uk":{"name":"Адренальний синдром Кушинга","synonyms":["Adrenal CS"],"definition":"A group of endogenous Cushing syndrome (CS) that may result from excess secretion of cortisol by either a unilateral and benign (adrenocortical adenoma), or malignant (adrenocortical carcinoma) adrenocortical tumor, or nodular adrenocortical disease, including Cushing syndrome due to bilateral macronodular adrenocortical disease (BMAD), isolated micronodular adrenocortical disease (i-MAD) and primary pigmented nodular adrenocortical disease (PPNAD; isolated or in Carney complex)."}},"xrefs":[{"source":"UMLS","code":"C0342443","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":99893,"name":"OBSOLETE: ACTH-independent Cushing syndrome","status":"inactive"},{"type":"Referred to","orpha":189424,"name":"OBSOLETE: ACTH-independent Cushing syndrome due to bilateral adrenocortical hyperplasia","status":"inactive"},{"type":"Referred to","orpha":443287,"name":"OBSOLETE: ACTH-independent Cushing syndrome due to rare cortisol-producing adrenal tumor","status":"inactive"},{"type":"Referred to","orpha":642013,"name":"OBSOLETE: Adrenal Cushing syndrome due to isolated adrenocortical benign tumor","status":"inactive"}],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":641613,"name":"Endogenous Cushing syndrome","classifications":[193]}],"children":[{"orpha":189427,"name":"Cushing syndrome due to bilateral macronodular adrenocortical disease","type":"Disease"},{"orpha":642788,"name":"Cushing syndrome due to cortisol-producing adrenocortical adenoma","type":"Disease"},{"orpha":314749,"name":"Rare disease with adrenal Cushing syndrome as a major feature","type":"Category"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}