{"orpha":60014,"name":"Argyria","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Silver staining"],"definition":"A rare dermatosis, which can be either localized or generalized, that occurs after prolonged contact and absorption of silver containing compounds over a period of years and that is characterized by irreversible blue-gray to gray-black staining of skin, fingernails and/or mucous membranes, most evident on sun exposed areas of the skin. Silver exposure is usually occupational but may also occur through dental amalgams, the ingestion of colloidal silver, acupuncture needles, orthopedic implants and topical medications (such as silver sulfadiazine).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-60014/","orphanet_url":"https://www.orpha.net/en/disease/detail/60014","names":{"fr":{"name":"Argyrie","synonyms":["Imprégnation cutanéo-muqueuse à l'argent"],"definition":"Dermatose rare, localisée ou généralisée, survenant à la suite d'un contact prolongé, sur une période de plusieurs années, et de l'ingestion de composés contenant de l'argent, qui se caractérise par une coloration irréversible bleu-gris à gris-noir de la peau, des ongles et/ou des muqueuses, plus manifeste sur les zones de la peau exposées au soleil. L'exposition à l'argent est généralement d'origine professionnelle, mais elle peut également être due aux amalgames dentaires, à l'ingestion d'argent colloïdal, aux aiguilles d'acupuncture, aux implants orthopédiques et aux médicaments topiques (tels que la sulfadiazine argentique)."},"de":{"name":"Argyrie","definition":"Eine seltene Dermatose, die entweder lokal oder generalisiert auftreten kann und nach jahrelangem Kontakt und Absorption silberhaltiger Verbindungen entsteht. Sie ist durch irreversible blaugraue bis grauschwarze Verfärbungen der Haut, Fingernägel und/oder Schleimhäute gekennzeichnet, die am deutlichsten an sonnenexponierten Hautpartien sichtbar sind. Silber wird in der Regel am Arbeitsplatz ausgesetzt, kann aber auch durch Zahnamalgam, die Einnahme von kolloidalem Silber, Akupunkturnadeln, orthopädische Implantate und topische Medikamente (wie Silbersulfadiazin) auftreten."},"es":{"name":"Argiria","synonyms":["Tinción de plata","Tinción por exposición a plata"],"definition":"Es una dermatosis poco frecuente, localizada o generalizada, que ocurre después del contacto prolongado y la absorción de compuestos que contienen plata durante un período de años. Está caracterizada por una tinción irreversible de la piel, las uñas y/o membranas mucosas de color gris azulado a gris negruzco, más evidente en áreas de la piel expuestas al sol. La exposición a la plata suele ser ocupacional, pero también puede ocurrir a través de amalgamas dentales, la ingestión de plata coloidal, agujas de acupuntura, implantes ortopédicos y medicamentos tópicos (como la sulfadiazina de plata)."},"it":{"name":"Argiria","synonyms":["Colorazione argento"]},"nl":{"name":"Argyrie","synonyms":["Zilverkleuring"],"definition":"Een zeldzame dermatose, die ofwel gelokaliseerd ofwel systemisch kan zijn en voorkomt na langdurig contact met en absorptie van zilverhoudende stoffen gedurende meerdere jaren, gekarakteriseerd door onomkeerbare blauwgrijze tot grijszwarte verkleuring van huid, vingernagels en/of slijmvlies, vooral op delen van de huid die worden blootgesteld aan de zon. Blootstelling aan zilver is doorgaans beroepsmatig maar kan ook voorkomen via amalgaam tandheelkundig vulmateriaal, inname van colloïdaal zilver, acupunctuurnaalden, orthopedische implantaten en topische medicatie (zoals zilversulfadiazine)."},"pt":{"name":"Argiria","synonyms":["Coloração pela prata"]},"pl":{"name":"Srebrzyca","synonyms":["Silver staining"]},"cs":{"name":"Argyrie","synonyms":["Šedavé zbarvení kůže"]},"uk":{"name":"Аргірія","synonyms":["Фарбування сріблом"],"definition":"A rare dermatosis, which can be either localized or generalized, that occurs after prolonged contact and absorption of silver containing compounds over a period of years and that is characterized by irreversible blue-gray to gray-black staining of skin, fingernails and/or mucous membranes, most evident on sun exposed areas of the skin. Silver exposure is usually occupational but may also occur through dental amalgams, the ingestion of colloidal silver, acupuncture needles, orthopedic implants and topical medications (such as silver sulfadiazine)."},"zh":{"name":"银质沉着病","synonyms":["银染色"]},"tr":{"name":"Arjiri","synonyms":["Gümüş boyama"]}},"xrefs":[{"source":"ICD-10","code":"T56.8","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"ED6Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"609692407"},{"source":"MONDO","code":"0018952","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D001129","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0003782","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10003094","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}