{"orpha":589595,"name":"Mixed phenotype acute leukemia with t(v;11q23.3)","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["MPAL with t(v;11q23.3); KMT2A rearranged","MPAL with t(v;11q23.3); MLL rearranged"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-589595/","orphanet_url":"https://www.orpha.net/en/disease/detail/589595","names":{"fr":{"name":"Leucémie aiguë de phénotype mixte associé à t(v;11q23.3)","synonyms":["MPAL avec t(v;11q23.3); KMT2A réarrangé","MPAL avec t(v;11q23.3); MLL réarrangé"]},"de":{"name":"Akute Leukämie mit gemischtem Phänotyp mit t(v;11q23.3)","synonyms":["MPAL mit t(v;11q23.3); KMT2A-Rearrangement","MPAL mit t(v;11q23.3); MLL-Rearrangement"]},"es":{"name":"Leucemia aguda de fenotipo mixto con t(v;11q23.3)","synonyms":["MPAL con t(v;11q23.3); reordenamiento del gen KMT2A","MPAL con t(v;11q23.3); reordenamiento del gen MLL"]},"it":{"name":"Leucemia acuta a fenotipo misto con t(v;11q23.3)","synonyms":["MPAL con t(v;11q23.3); riarrangiamenti in KMT2A","MPAL con t(v;11q23.3); riarrangiamenti in MLL"]},"nl":{"name":"Acute leukemie met gemengd fenotype en t(v;11q23.3)","synonyms":["MPAL met t(v;11q23.3); KMT2A herschikt","MPAL met t(v;11q23.3); MLL herschikt"]},"pt":{"name":"Leucemia aguda de fenótipo misto com t(v;11q23.3)"},"pl":{"name":"Ostra białaczka o mieszanym fenotypie z t(v;11q23.3)","synonyms":["MPAL with t(v;11q23.3); KMT2A rearranged","MPAL with t(v;11q23.3); MLL rearranged"]},"cs":{"name":"Akutní leukémie se smíšeným fenotypem s t(v;11q23.3)","synonyms":["MPAL with t(v;11q23.3); KMT2A rearranged","MPAL with t(v;11q23.3); MLL rearranged"]},"uk":{"name":"Гострий лейкоз зі змішаним фенотипом з t(v;11q23.3)","synonyms":["MPAL з t(v;11q23.3); KMT2A реаранжування","MPAL з t(v;11q23.3); MLL реаранжування"]},"zh":{"name":"Mixed phenotype acute leukemia with t(v;11q23.3)","synonyms":["MPAL with t(v;11q23.3); KMT2A rearranged","MPAL with t(v;11q23.3); MLL rearranged"]},"tr":{"name":"Mixed phenotype acute leukemia with t(v;11q23.3)","synonyms":["MPAL with t(v;11q23.3); KMT2A rearranged","MPAL with t(v;11q23.3); MLL rearranged"]}},"xrefs":[{"source":"ICD-10","code":"C92.6","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"424104055"},{"source":"MONDO","code":"0035642","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2826048","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":530995,"name":"Mixed phenotype acute leukemia","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"FLT3","name":"fms related receptor tyrosine kinase 3","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"27069254[PMID]_29072953[PMID]_26276768[PMID]","hgnc":"3765","ensembl":"ENSG00000122025","omim":"136351","loci":["13q12.2"]},{"symbol":"AFF1","name":"ALF transcription elongation factor 1","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":null,"hgnc":"7135","ensembl":"ENSG00000172493","omim":"159557","loci":["4q21.3-q22.1"]},{"symbol":"KMT2A","name":"lysine methyltransferase 2A","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"27069254[PMID]_29072953[PMID]_26276768[PMID]","hgnc":"7132","ensembl":"ENSG00000118058","omim":"159555","loci":["11q23.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Infancy"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumour[OTHER]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumour[OTHER]_ORPHANET"}],"phenotypes":null}