{"orpha":589534,"name":"Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-589534/","orphanet_url":"https://www.orpha.net/en/disease/detail/589534","names":{"fr":{"name":"Leucémie aiguë de phénotype mixte associé à t(9;22)(q34.1;q11.2)","synonyms":["MPAL associé à t(9;22)(q34.1;q11.2); BCR-ABL1"]},"de":{"name":"Akute Leukämie mit gemischtem Phänotyp mit t(9;22)(q34.1;q11.2)","synonyms":["MPAL mit t(9;22)(q34.1;q11.2); BCR-ABL1"]},"es":{"name":"Leucemia aguda de fenotipo mixto con t(9; 22)(q34.1;q11.2)","synonyms":["MPAL con t(9;22)(q34.1;q11.2); BCR-ABL1"]},"it":{"name":"Leucemia acuta a fenotipo misto con t(9;22)(q34.1;q11.2)","synonyms":["MPAL con t(9;22)(q34.1;q11.2); BCR-ABL1"]},"nl":{"name":"Acute leukemie met gemengd fenotype en t(9;22)(q34.1;q11.2)","synonyms":["MPAL met t(9;22)(q34.1;q11.2); BCR-ABL1"]},"pt":{"name":"Leucemia aguda de fenótipo misto com t(9;22)(q34.1;q11.2)"},"pl":{"name":"Ostra białaczka o mieszanym fenotypie z t(9;22)(q34.1;q11.2)","synonyms":["MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"]},"cs":{"name":"Akutní leukémie se smíšeným fenotypem s t(9;22)(q34.1;q11.2)","synonyms":["MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"]},"uk":{"name":"Гострий лейкоз зі змішаним фенотипом з t(9;22)(q34.1;q11.2)","synonyms":["MPAL з t(9;22)(q34.1;q11.2); BCR-ABL1"]},"zh":{"name":"Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)","synonyms":["MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"]},"tr":{"name":"Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)","synonyms":["MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"]}},"xrefs":[{"source":"ICD-10","code":"C92.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1951762156"},{"source":"ICD-11","code":"XH97B7","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"70044537"},{"source":"MONDO","code":"0035639","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2826037","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":530995,"name":"Mixed phenotype acute leukemia","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"FLT3","name":"fms related receptor tyrosine kinase 3","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"27069254[PMID]_29072953[PMID]_26276768[PMID]","hgnc":"3765","ensembl":"ENSG00000122025","omim":"136351","loci":["13q12.2"]},{"symbol":"KMT2A","name":"lysine methyltransferase 2A","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"27069254[PMID]_29072953[PMID]_26276768[PMID]","hgnc":"7132","ensembl":"ENSG00000118058","omim":"159555","loci":["11q23.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"}],"phenotypes":null}