{"orpha":585956,"name":"B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-585956/","orphanet_url":"https://www.orpha.net/en/disease/detail/585956","names":{"fr":{"name":"Leucémie/lymphome lymphoblastique B associé à t(1;19)(q23;p13.3)","synonyms":["Leucémie/lymphome lymphoblastique B avec t(1;19)(q23;p13.3); TCF3-PBX1"]},"de":{"name":"B-lymphoblastische Leukämie/Lymphom mit t(1;19)(q23;p13.3)","synonyms":["B-lymphoblastische Leukämie/Lymphom mit t(1;19)(q23;p13.3); TCF3-PBX1"]},"es":{"name":"Leucemia/linfoma linfoblástico B con t(1;19)(q23;p13.3)","synonyms":["Leucemia/linfoma linfoblástico de células B con t(1;19)(q23;p13.3); TCF3-PBX1"]},"it":{"name":"Leucemia linfoblastica a cellule B/linfoma con t(1;19)(q23;p13.3)","synonyms":["Leucemia linfoblastica a cellule B/linfoma con t(1;19)(q23;p13.3); TCF3-PBX1"]},"nl":{"name":"B-lymfoblastische leukemie/lymfoom met t(1;19)(q23;p13.3)","synonyms":["B-lymfoblastische leukemie/lymfoom met t(1;19)(q23;p13.3); TCF3-PBX1"]},"pt":{"name":"Leucemia/linfoma linfoblástico-B com t(1;19)(q23;p13.3)"},"pl":{"name":"Białaczka/chłoniak limfoblastyczny z komórek B z t(1;19)(q23;p13.3)","synonyms":["Białaczka/chłoniak limfoblastyczny z komórek B z t(1;19)(q23;p13.3); TCF3-PBX1"]},"cs":{"name":"B-lymfoblastická leukémie/lymfom s t(1;19)(q23;p13.3)","synonyms":["B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1"]},"uk":{"name":"В-лімфобластний лейкоз/лімфома з t(1;19)(q23;p13.3)","synonyms":["Лімфобластний лейкоз В, лімфома з t(1;19)(q23;p13.3); TCF3-PBX1"]},"zh":{"name":"B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)","synonyms":["B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1"]},"tr":{"name":"B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)","synonyms":["B lymphoblastic leukemia lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1"]}},"xrefs":[{"source":"ICD-10","code":"C91.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A70.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"877168682"},{"source":"ICD-11","code":"XH3GU8","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"410073608"},{"source":"MONDO","code":"0600030","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2698315","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":99860,"name":"Precursor B-cell acute lymphoblastic leukemia","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"PBX1","name":"PBX homeobox 1","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"31575852[PMID]","hgnc":"8632","ensembl":"ENSG00000185630","omim":"176310","loci":["1q23.3"]},{"symbol":"TCF3","name":"transcription factor 3","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"31575852[PMID]","hgnc":"11633","ensembl":"ENSG00000071564","omim":"147141","loci":["19p13.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"}],"phenotypes":null}