{"orpha":585936,"name":"B-lymphoblastic leukemia/lymphoma with hyperdiploidy","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-585936/","orphanet_url":"https://www.orpha.net/en/disease/detail/585936","names":{"fr":{"name":"Leucémie/lymphome lymphoblastique B avec hyperdiploïdie"},"de":{"name":"B-lymphoblastische Leukämie/Lymphom mit Hyperdiploidie"},"es":{"name":"Leucemia/linfoma linfoblástico de células B con hiperdiploidía"},"it":{"name":"Leucemia linfoblastica a cellule B/linfoma con iperdiploidia"},"nl":{"name":"B-lymfoblastische leukemie/lymfoom met hyperdiploïdie"},"pt":{"name":"Leucemia/linfoma linfoblástico-B com hiperdiploidia"},"pl":{"name":"Białaczka/chłoniak limfoblastyczny z komórek B z hiperdiploidią"},"cs":{"name":"B-lymfoblastická leukémie/lymfom s hyperdiploidií"},"uk":{"name":"В-лімфобластний лейкоз/лімфома з гіпердіплоїдією"},"zh":{"name":"B-lymphoblastic leukemia/lymphoma with hyperdiploidy"},"tr":{"name":"B-lymphoblastic leukemia/lymphoma with hyperdiploidy"}},"xrefs":[{"source":"ICD-10","code":"C91.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A70.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"409224646"},{"source":"MONDO","code":"0035943","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2698311","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":99860,"name":"Precursor B-cell acute lymphoblastic leukemia","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"GATA3","name":"GATA binding protein 3","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"23996088[PMID]_24141364[PMID]_24203929[PMID]","hgnc":"4172","ensembl":"ENSG00000107485","omim":"131320","loci":["10p14"]},{"symbol":"PIP4K2A","name":"phosphatidylinositol-5-phosphate 4-kinase type 2 alpha","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"23996088[PMID]","hgnc":"8997","ensembl":"ENSG00000150867","omim":"603140","loci":["10p12.2"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"WHO Classification of Tumours[OTHER]_ORPHANET"}],"phenotypes":null}