{"orpha":576074,"name":"Middle East respiratory syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["MERS"],"definition":"A rare infectious disease caused by Middle East respiratory syndrome coronavirus (MERS&#8208;CoV) and characterized by a spectrum of illness, ranging from mild upper respiratory symptoms to rapidly progressive lower respiratory infection/pneumonia potentially leading to acute respiratory distress syndrome (ARDS), multi-system organ failure, and death. Presenting signs and symptoms typically include fever, cough, shortness of breath, chills, dyspnea, myalgia, abdominal pain, nausea, vomiting, and diarrhea.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-576074/","orphanet_url":"https://www.orpha.net/en/disease/detail/576074","names":{"fr":{"name":"Syndrome respiratoire du Moyen-Orient","synonyms":["MERS"],"definition":"Maladie infectieuse rare causée par le coronavirus responsable du syndrome respiratoire du Moyen-Orient (MERS-CoV) et caractérisée par un spectre de maladies allant de symptômes légers des voies respiratoires supérieures à une infection/pneumonie rapidement progressive des voies respiratoires inférieures pouvant conduire au syndrome de détresse respiratoire aiguë (SDRA), à une défaillance multiviscérale et au décès. Les signes et symptômes typiques sont la fièvre, la toux, l'essoufflement, les frissons, la dyspnée, les myalgies, les douleurs abdominales, les nausées, les vomissements et la diarrhée."},"de":{"name":"Mittlerer-Osten-Atemwegssyndrom","synonyms":["MERS"],"definition":"Eine seltene Infektionskrankheit, die durch das Middle East Respiratory Syndrome Coronavirus (MERS-CoV) verursacht wird und durch ein Krankheitsspektrum gekennzeichnet ist, das von leichten Symptomen der oberen Atemwege bis hin zu einer schnell fortschreitenden Infektion/Lungenentzündung der unteren Atemwege reicht, die möglicherweise zu einem akuten Atemnotsyndrom (ARDS), Multiorganversagen und zum Tod führt. Zu den typischen Anzeichen und Symptomen gehören Fieber, Husten, Kurzatmigkeit, Schüttelfrost, Atemnot, Myalgie, Bauchschmerzen, Übelkeit, Erbrechen und Durchfall."},"es":{"name":"Síndrome respiratorio de Oriente Medio","synonyms":["MERS"],"definition":"Es una enfermedad infecciosa poco frecuente causada por el coronavirus responsable del síndrome respiratorio de Oriente Medio (MERS&#8208;CoV) y caracterizada por un espectro de enfermedades que van desde síntomas leves de las vías respiratorias superiores hasta una infección/neumonía de las vías respiratorias inferiores rápidamente progresiva que puede evolucionar a síndrome de dificultad respiratoria aguda (SDRA), insuficiencia orgánica multisistémica y fallecimiento. Los signos y síntomas que se presentan típicamente incluyen fiebre, tos, dificultad respiratoria, escalofríos, disnea, mialgia, dolor abdominal, náuseas, vómitos y diarrea."},"it":{"name":"Sindrome respiratoria del Medio Oriente","synonyms":["MERS"]},"nl":{"name":"Midden-Oosten respiratoir syndroom","synonyms":["MERS"],"definition":"Een zeldzame infectieziekte, veroorzaakt door Midden-Oosten respiratoir syndroom-coronavirus (MERS&#8208;CoV), en gekenmerkt door een ziektespectrum gaande van milde symptomen van bovenste luchtwegen tot snel progressieve infectie van onderste luchtwegen/pneumonie die potentieel leidt tot syndroom van acute ademnood (ARDS), multisystemisch orgaanfalen, en sterfte. Typische presenterende verschijnselen en symptomen zijn koorts, hoest, kortademigheid, rillingen, dyspneu, spierpijn, abdominale pijn, misselijkheid, braken, en diarree."},"pt":{"name":"Síndrome Respiratório do Médio Oriente","synonyms":["MERS"],"definition":"Doença infeciosa rara causada pelo coronavírus da síndrome respiratória do Médio Oriente (MERS&#8208;CoV) e caracterizada por um espectro de doença que varia de sintomas respiratórios superiores leves a infeção/pneumonia do trato respiratório inferior rapidamente progressiva, potencialmente levando à síndrome do desconforto respiratório agudo (SDRA), falência multissistémica de órgãos e morte. Os sinais e sintomas apresentados geralmente incluem febre, tosse, respiração superficial, calafrios, dispneia, mialgias, dor abdominal, náuseas, vómitos e diarreia."},"pl":{"name":"Zespół oddechowy na Bliskim Wschodzie","synonyms":["MERS"]},"cs":{"name":"Respirační syndrom na Středním východě","synonyms":["MERS"]},"uk":{"name":"Близькосхідний респіраторний синдром","synonyms":["MERS"],"definition":"A rare infectious disease caused by Middle East respiratory syndrome coronavirus (MERS&#8208;CoV) and characterized by a spectrum of illness, ranging from mild upper respiratory symptoms to rapidly progressive lower respiratory infection/pneumonia potentially leading to acute respiratory distress syndrome (ARDS), multi-system organ failure, and death. Presenting signs and symptoms typically include fever, cough, shortness of breath, chills, dyspnea, myalgia, abdominal pain, nausea, vomiting, and diarrhea."},"zh":{"name":"中东呼吸综合征","synonyms":["MERS"]},"tr":{"name":"Orta Doğu solunum sendromu","synonyms":["MERS"]}},"xrefs":[{"source":"ICD-10","code":"B34.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1D64","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1840423014"},{"source":"MONDO","code":"0100116","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D065207","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C3694279","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10075271","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":2613.0,"area":"Worldwide","status":"Validated","source":"World Health Organization 2024[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"World Health Organization 2024[OTHER]_ORPHANET"}],"phenotypes":null}