{"orpha":573163,"name":"Pheochromocytoma-paraganglioma","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":"A rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla (pheochromocytoma) or from sympathetic and parasympathetic ganglia (paraganglioma). These tumors are most often benign and may produce catecholamines in excess causing hypertension and sometimes severe acute cardiovascular complications.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-573163/","orphanet_url":"https://www.orpha.net/en/disease/detail/573163","names":{"fr":{"name":"Phéochromocytome-paragangliome","definition":"Tumeurs neuroendocrines rares se développant aux dépens des cellules chromaffines de la médullosurrénale (phéochromocytome) et des ganglions sympathiques ou parasympathiques (paragangliomes). Ces tumeurs sont le plus souvent bénignes et peuvent produire des catécholamines en excès, à l'origine d'une hypertension artérielle et d'éventuelles complications cardiovasculaires aiguës."},"de":{"name":"Phaeochromozytom-Paragangliom-Syndrom","definition":"Ein seltener neuroendokriner Tumor, der von chromaffinen Zellen des Nebennierenmarks (Phäochromozytom) oder von sympathischen und parasympathischen Ganglien (Paragangliom) ausgeht. Diese Tumore sind in den meisten Fällen gutartig und können einen Überschuss an Katecholaminen produzieren, der Bluthochdruck und manchmal schwere akute kardiovaskuläre Komplikationen verursacht."},"es":{"name":"Feocromocitoma-paraganglioma","definition":"Es un tumor neuroendocrino poco frecuente que surge de las células cromafines de la médula suprarrenal (feocromocitoma) o de los ganglios simpáticos y parasimpáticos (paraganglioma). Estos tumores suelen ser benignos y pueden producir catecolaminas en exceso, lo que causa hipertensión y, en ocasiones, complicaciones cardiovasculares agudas graves."},"it":{"name":"Feocromocitoma-paraganglioma","definition":"Si tratta neoplasie neuroendocrine rare che originano dalle cellule cromaffini della midollare del surrene (feocromocitoma) o dai gangli simpatici e parasimpatici (paraganglioma). Nella maggior parte dei casi i tumori sono benigni e possono associarsi ad una ipersecrezione di catecolamine, che causa ipertensione e, talvolta, complicanze cardiovascolari acute e gravi."},"nl":{"name":"Feochromocytoom-paraganglioom","definition":"Een zeldzame neuro-endocriene tumor die ontstaat uit chromaffiene cellen van bijniermerg (feochromocytoom) of uit sympathische en parasympathische ganglia (paraganglioom). Deze tumoren zijn meestal goedaardig en kunnen overmaat aan catecholamines produceren, wat leidt tot hypertensie en soms ernstige acute cardiovasculaire complicaties."},"pt":{"name":"Feocromocitoma-paraganglioma"},"pl":{"name":"Guz chromochłonny nadnercza i przyzwojak"},"cs":{"name":"Feochromocytom-paragangliom"},"uk":{"name":"Феохромоцитома-парагангліома","definition":"A rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla (pheochromocytoma) or from sympathetic and parasympathetic ganglia (paraganglioma). These tumors are most often benign and may produce catecholamines in excess causing hypertension and sometimes severe acute cardiovascular complications."},"zh":{"name":"嗜铬细胞瘤-副神经节瘤","definition":"一种罕见的神经内分泌肿瘤，产生于肾上腺髓质的嗜铬细胞瘤（嗜铬细胞瘤）或交感神经节和副交感神经节（副神经节瘤）。这些肿瘤最常见的是良性的，可能会产生过多的儿茶酚胺，引起高血压，有时还会引起严重的急性心血管并发症。"},"tr":{"name":"Feokromositom-paragangliom"}},"xrefs":[{"source":"MONDO","code":"0035540","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5681712","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":100091,"name":"Adrenal/paraganglial tumor","classifications":[193,202]}],"children":[{"orpha":324299,"name":"EPAS1-related polycythemia-pheochromocytoma/paraganglioma syndrome","type":"Disease"},{"orpha":29072,"name":"Hereditary pheochromocytoma-paraganglioma","type":"Disease"},{"orpha":94080,"name":"Non-functioning paraganglioma","type":"Disease"},{"orpha":276621,"name":"Sporadic pheochromocytoma/secreting paraganglioma","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}