{"orpha":57196,"name":"Medial condensing osteitis of the clavicle","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Osteitis condensans of the clavicle"],"definition":"A rare bone disease characterized by benign, usually unilateral, sclerosis of the inferomedial third of the clavicle. Patients present with localized swelling and persistent pain. Typical radiographic findings are expansion of the medial end of the clavicle with increased radio-density and signs of bone remodeling.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-57196/","orphanet_url":"https://www.orpha.net/en/disease/detail/57196","names":{"fr":{"name":"Ostéite condensante médiane de la clavicule","definition":"Maladie osseuse rare caractérisée par une sclérose bénigne, généralement unilatérale, du tiers médial inférieur de la clavicule. Les patients présentent un oedème localisé et une douleur persistante. Les signes radiographiques typiques sont une expansion de l'extrémité médiale de la clavicule avec une augmentation de la radiodensité et des signes de remodelage osseux."},"de":{"name":"Kondensierende Ostitis der medialen Klavikula","definition":"Eine seltene Knochenkrankheit, die durch eine gutartige, meist einseitige Sklerose des inferomedialen Drittels des Schlüsselbeins gekennzeichnet ist. Die Patienten weisen eine lokale Schwellung und anhaltende Schmerzen auf. Typische Röntgenbefunde sind eine Verbreiterung des medialen Endes der Klavikula mit erhöhter Radiodichte und Zeichen des Knochenumbaus."},"es":{"name":"Osteítis condensante medial de la clavícula","synonyms":["Osteítis condensante de la clavícula"],"definition":"Es una enfermedad ósea poco frecuente caracterizada por esclerosis benigna, generalmente unilateral, del tercio inferomedial de la clavícula. Los pacientes manifiestan hinchazón localizada y dolor persistente. Los hallazgos radiológicos típicos son la expansión del extremo medial de la clavícula con aumento de la radiodensidad y signos de remodelado óseo."},"it":{"name":"Osteite condensante della parte mediana della clavicola","definition":"Si tratta di una malattia scheletrica rara, caratterizzata da sclerosi benigna, di solito monolaterale, del terzo infero-mediale della clavicola. I pazienti presentano gonfiore localizzato e dolore persistente. In genere le radiografie evidenziano un allargamento dell'estremità mediana della clavicola con un aumento della radiodensità ed evidenza di rimodellamento osseo."},"nl":{"name":"Mediale condenserende osteïtis van clavicula","synonyms":["Mediale condenserende osteïtis van sleutelbeen","Osteitis condensans van clavicula"],"definition":"Een botaandoening, gekarakteriseerd door goedaardige, meestal unilaterale sclerose van het inferomediale derde deel van sleutelbeen. Patiënten presenteren zich met gelokaliseerde zwelling en aanhoudende pijn. Typische bevindingen van radiografie zijn expansie van het mediale uiteinde van sleutelbeen met verhoogde radiografische densiteit en verschijnselen van remodellering van bot."},"pt":{"name":"Osteíte condensante da clavícula medial"},"pl":{"name":"Pośrodkowe kondensujące zapalenie obojczyka","synonyms":["Kondensujące zapalenie obojczyka"]},"cs":{"name":"Mediální kondenzující osteitida klavikuly","synonyms":["Osteitis condensans of the clavicle"]},"uk":{"name":"Медіальний конденсаційний остеїт ключиці","synonyms":["Ущільнений остеїт ключиці"],"definition":"A rare bone disease characterized by benign, usually unilateral, sclerosis of the inferomedial third of the clavicle. Patients present with localized swelling and persistent pain. Typical radiographic findings are expansion of the medial end of the clavicle with increased radio-density and signs of bone remodeling."},"zh":{"name":"锁骨内侧压缩性骨炎","synonyms":["锁骨致密性骨炎"]},"tr":{"name":"Klavikulanın medial yoğunlaşan osteiti","synonyms":["Klavikulanın osteit kondansanları"]}},"xrefs":[{"source":"ICD-10","code":"M85.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"LB72.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1641338379"},{"source":"MONDO","code":"0018929","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5396729","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"10910","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93419,"name":"Rare bone disease"},"parents":[{"orpha":399319,"name":"Osteochondrosis","classifications":[196,199]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":58.0,"area":"Worldwide","status":"Validated","source":"27622150[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_27622150[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-05-27","source":"15329764[PMID]_25272551[PMID]_27622150[PMID]","terms":[{"hpo":"HP:0000889","label":"Abnormality of the clavicle","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010657","label":"Patchy reduction of bone mineral density","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030834","label":"Shoulder pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006467","label":"Limited shoulder movement","frequency":"Occasional (29-5%)","criteria":null}]}}