{"orpha":570470,"name":"Ricin poisoning","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare disorder due to poisoning characterized by acute onset of potentially life-threatening illness following ingestion, inhalation, or injection of ricin, a lectin present in the seeds of <i>Ricinus communis</i>, the castor oil plant. Clinical presentation depends on the route of administration, inhalation being the most toxic route, followed by oral ingestion. Presenting signs and symptoms include nausea, vomiting, diarrhea, hematemesis, and melena (upon ingestion), cough, wheezing, dyspnea, sore throat, and congestion (upon inhalation), and erythema, induration, blisters, capillary leak syndrome, and localized necrosis (upon injection). The condition can progress to seizures, shock, organ failure, pulmonary edema, and respiratory failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-570470/","orphanet_url":"https://www.orpha.net/en/disease/detail/570470","names":{"fr":{"name":"Intoxication à la ricine","definition":"Maladie rare due à une intoxication, caractérisée par l'apparition soudaine de symptômes pouvant engager le pronostic vital après ingestion, inhalation ou injection de ricine, une lectine présente dans les graines de <i>Ricinus communis</i> (ricin commun). La présentation clinique dépend de la voie d'administration, l'inhalation étant la voie la plus toxique suivie de l'ingestion orale. Les premiers signes et symptômes sont nausées, vomissements, diarrhée, hématémèse et méléna (en cas d'ingestion), toux, respiration sifflante, dyspnée, maux de gorge et congestion (en cas d'inhalation), et érythème, induration, cloques, syndrome de fuite capillaire et nécrose localisée (en cas d'injection). Les signes et symptômes peuvent évoluer vers des convulsions, un choc, une défaillance d'organe, un oedème pulmonaire et une insuffisance respiratoire."},"de":{"name":"Rizin-Vergiftung","definition":"Eine seltene Form der Vergiftung, bei der nach Einnahme, Inhalation oder Injektion von Ricin, einem Lektin aus den Samen des Rizinus <i>Ricinus communis</i>, der Rizinuspflanze, eine akute, lebensbedrohliche Erkrankung auftritt. Das klinische Erscheinungsbild hängt von der Art der Aufnahme ab, wobei die Inhalation am giftigsten ist, gefolgt von der oralen Aufnahme. Zu den Anzeichen und Symptomen gehören Übelkeit, Erbrechen, Durchfall, Bluterbrechen und Melena (bei oraler Aufnahme), Husten, Keuchen, Kurzatmigkeit, Halsschmerzen und Atemlähmung (bei Inhalation) sowie Erythem, Induration, Blasen, Kapillarlecksyndrom und lokale Nekrose (bei Injektion). Der Zustand kann zu Krampfanfällen, Schock, Organversagen, Lungenödem und Atemstillstand führen."},"es":{"name":"Intoxicación por ricina","definition":"Es un trastorno poco frecuente por intoxicación caracterizado por el inicio agudo de una enfermedad potencialmente mortal después de la ingestión, la inhalación o la inyección de ricina, una lectina presente en las semillas de <i>Ricinus communis</i>, la planta de aceite de ricino. La presentación clínica depende del modo de administración, siendo la inhalación la vía más tóxica, seguida de la ingestión oral. Los signos y síntomas de presentación incluyen náuseas, vómitos, diarrea, hematemesis y melena (en caso de ingestión), tos, sibilancias, disnea, dolor de garganta y congestión (por vía inhalatoria) y eritema, induración, ampollas, síndrome de extravasación capilar y necrosis localizada (tras la inyección). El trastorno puede derivar en crisis epilépticas, shock, fallo orgánico, edema pulmonar e insuficiencia respiratoria."},"it":{"name":"Avvelenamento da ricina","definition":"Si tratta di un avvelenamento raro che esita in una malattia potenzialmente letale ad insorgenza acuta causata dall'ingestione, dall'inalazione o dall'iniezione di ricina, una lectina presente nei semi di <i>Ricinus communis</i>, la pianta del ricino. Il quadro clinico dipende dalla via di somministrazione; l'inalazione è maggiormente tossica, seguita dall'ingestione orale. I segni clinici d'esordio comprendono la nausea, il vomito, la diarrea, l'ematemesi e la melena (nel caso di ingestione), la tosse, l'affanno, la dispnea, il mal di gola e la congestione (nel caso di inalazione), e l'eritema, l'indurimento, le vesciche, la sindrome da permeabilità capillare e la necrosi localizzata (nel caso di iniezione). L'avvelenamento può progredire con convulsioni, shock, insufficienza d'organo, edema polmonare e insufficienza respiratoria."},"nl":{"name":"Intoxicatie door ricine","synonyms":["Vergiftiging door ricine"],"definition":"Een zeldzame aandoening door intoxicatie, gekarakteriseerd door acute aanvang van potentieel levensbedreigende ziekte na inname, inhalatie of injectie van ricine, een lectine dat aanwezig is in zaden van <i>Ricinus communis</i>, de wonderboom. De klinische presentatie hangt af van de route van toediening, waarbij inhalatie de meest toxische route is, gevolgd door orale inname. Presenterende verschijnselen en symptomen zijn onder meer misselijkheid, braken, diarree, hematemese, en melena (na inname), hoest, piepende ademhaling, dyspneu, pijnlijke keel, en congestie (na inhalatie), en erytheem, induratie, blaarvorming, capillair-leksyndroom, en gelokaliseerde necrose (na injectie). De aandoening kan evolueren naar insulten, shock, orgaanfalen, longoedeem, en respiratoir falen."},"pt":{"name":"Envenenamento por rícino"},"pl":{"name":"Zatrucie rycyną"},"cs":{"name":"Otrava ricinem"},"uk":{"name":"Отруєння рицином","definition":"A rare disorder due to poisoning characterized by acute onset of potentially life-threatening illness following ingestion, inhalation, or injection of ricin, a lectin present in the seeds of <i>Ricinus communis</i>, the castor oil plant. Clinical presentation depends on the route of administration, inhalation being the most toxic route, followed by oral ingestion. Presenting signs and symptoms include nausea, vomiting, diarrhea, hematemesis, and melena (upon ingestion), cough, wheezing, dyspnea, sore throat, and congestion (upon inhalation), and erythema, induration, blisters, capillary leak syndrome, and localized necrosis (upon injection). The condition can progress to seizures, shock, organ failure, pulmonary edema, and respiratory failure."},"zh":{"name":"萞麻毒素中毒"},"tr":{"name":"Ricin zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T62.2","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"264256198"},{"source":"MONDO","code":"0035511","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1443942","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]},{"orpha":97992,"name":"Rare hematologic disease","classifications":[194]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"}],"phenotypes":null}