{"orpha":563,"name":"Peripartum cardiomyopathy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Postpartum cardiomyopathy"],"definition":"Peripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-563/","orphanet_url":"https://www.orpha.net/en/disease/detail/563","names":{"fr":{"name":"Myocardiopathie gravidique primitive","synonyms":["Cardiomyopathie du péri-partum","Cardiomyopathie gravidique","Syndrome de Meadows"],"definition":"La cardiomyopathie gravidique primitive est une forme idiopathique potentiellement fatale de cardiomyopathie dilatée, qui se développe au cours du dernier mois de la grossesse ou jusqu'à cinq mois après l'accouchement."},"de":{"name":"Kardiomyopathie, peripartale","synonyms":["Kardiomyopathie, postpartale","Meadows-Syndrom","PPCM","PPCMP","Peripartumkardiomyopathie"],"definition":"Die peripartale Kardiomyopathie (PPCM) ist eine idiopathische, potenziell tödliche Form der dilatativen Kardiomyopathie, die sich im letzten Monat der Schwangerschaft oder innerhalb von fünf Monaten nach der Entbindung entwickelt"},"es":{"name":"Miocardiopatía periparto","synonyms":["Cardiomiopatía periparto","Cardiomiopatía postparto","Síndrome de Meadow"],"definition":"Es una forma idiopática y potencialmente mortal de miocardiopatía dilatada que se desarrolla durante el último mes del embarazo o dentro de los cinco meses posteriores al parto."},"it":{"name":"Cardiomiopatia periparto","synonyms":["Cardiomiopatia postparto","Sindrome di Meadow"]},"nl":{"name":"Peripartumcardiomyopathie","synonyms":["Postpartumcardiomyopathie"],"definition":"Peripartum cardiomyopathie (PPCM) is een idiopathische, potentieel dodelijke vorm van gedilateerde cardiomyopathie die zich ontwikkelt tijdens de laatste maand van de zwangerschap of binnen vijf maanden na de bevalling."},"pt":{"name":"Miocardiopatia peri-parto","synonyms":["Miocardiopatia pós-parto"]},"pl":{"name":"Kardiomiopatia okołoporodowa","synonyms":["Kardiomiopatia poporodowa"]},"cs":{"name":"Peripartum kardiomyopatie","synonyms":["Postpartum kardiomyopatie"]},"uk":{"name":"Перинатальна кардіоміопатія","synonyms":["Післяпологова кардіоміопатія"],"definition":"Peripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery."},"zh":{"name":"围产期心肌病","synonyms":["产后心肌病"]},"tr":{"name":"Peripartum kardiyomiyopatisi","synonyms":["Doğum sonrası kardiyomiyopati"]}},"xrefs":[{"source":"ICD-10","code":"O90.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"JB44.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1218807936"},{"source":"MONDO","code":"0018920","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0877208","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"220","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10049430","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97929,"name":"Rare cardiac disease"},"parents":[{"orpha":217629,"name":"Non-familial dilated cardiomyopathy","classifications":[146]},{"orpha":506225,"name":"Rare disorder potentially indicated for heart transplant","classifications":[233]},{"orpha":163637,"name":"Rare disorder related with pregnancy, childbirth and puerperium","classifications":[205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["Adult"],"prevalence":[{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":30.0,"area":"Worldwide","status":"Not yet validated","source":"10703781[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":36.0,"area":"United States","status":"Not yet validated","source":"23090517[PMID]_10703781[PMID]_16765131[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":89.0,"area":"Singapore","status":"Validated","source":"23338912[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-9 / 100 000","value":5.0,"area":"Japan","status":"Validated","source":"21617320[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":334.0,"area":"Haiti","status":"Validated","source":"16342653[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":100.0,"area":"South Africa","status":"Validated","source":"16920474[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-05-28","source":"27045128[PMID]_28765406[PMID]_25636745[PMID]","terms":[{"hpo":"HP:0005135","label":"Abnormal T-wave","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001644","label":"Dilated cardiomyopathy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030848","label":"Elevated jugular venous pressure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002875","label":"Exertional dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001712","label":"Left ventricular hypertrophy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025169","label":"Left ventricular systolic dysfunction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012764","label":"Orthopnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001962","label":"Palpitations","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010741","label":"Pedal edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012664","label":"Reduced left ventricular ejection fraction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011703","label":"Sinus tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006705","label":"Abnormal atrioventricular valve morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005120","label":"Abnormal cardiac atrium morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030830","label":"Crackles","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030148","label":"Heart murmur","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030356","label":"Increased serum interferon-gamma level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031295","label":"Left atrial enlargement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001653","label":"Mitral regurgitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012763","label":"Paroxysmal dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012398","label":"Peripheral edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100602","label":"Preeclampsia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002092","label":"Pulmonary arterial hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005133","label":"Right ventricular dilatation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001708","label":"Right ventricular failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001907","label":"Thromboembolism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100603","label":"Toxemia of pregnancy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004756","label":"Ventricular tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002926","label":"Abnormality of thyroid physiology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002099","label":"Asthma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030149","label":"Cardiogenic shock","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000819","label":"Diabetes mellitus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011713","label":"Left bundle branch block","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001513","label":"Obesity","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002401","label":"Stroke-like episode","frequency":"Very rare (<4-1%)","criteria":null}]}}