{"orpha":55655,"name":"Pneumococcal meningitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare infectious disease of the nervous system caused by the bacterium Streptococcus pneumoniae, which is commonly part of the bacterial flora colonizing the nasopharyngeal mucosa. The disease is clinically characterized by typical symptoms of acute leptomeningitis, like fever, headache, neck stiffness, vomiting, and clouding of consciousness. It is frequently fatal and, in surviving patients, often accompanied by long-term sequelae, especially focal neurological deficits, hearing loss, cognitive impairment, and epilepsy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-55655/","orphanet_url":"https://www.orpha.net/en/disease/detail/55655","names":{"fr":{"name":"Méningite à pneumocoques","definition":"Maladie infectieuse rare du système nerveux due à la bactérie <i>Streptococcus pneumoniae</i>, qui fait partie de la flore bactérienne de la muqueuse nasopharyngée. Les signes cliniques typiques de la maladie sont ceux d'une leptoméningite aiguë, tels que fièvre, céphalées, raideur de la nuque, vomissements et état confusionnel. La maladie est fréquemment létale et, chez les patients qui y survivent, elle laisse souvent des séquelles à long-terme, notamment des déficits neurologiques focaux, une perte auditive, un trouble cognitif et une épilepsie."},"de":{"name":"Pneumokokken-Meningitis","definition":"Eine seltene Infektionskrankheit des Nervensystems, die durch das Bakterium <i>Streptococcus pneumoniae</i> verursacht wird, das üblicherweise Teil der Bakterienflora ist, die die Nasen-Rachen-Schleimhaut besiedelt. Klinisch ist die Krankheit durch typische Symptome einer akuten Leptomeningitis wie Fieber, Kopfschmerzen, Nackensteifigkeit, Erbrechen und Bewusstseinstrübung gekennzeichnet. Sie verläuft häufig tödlich und geht bei überlebenden Patienten oft mit Langzeitfolgen einher, insbesondere mit fokalen neurologischen Defiziten, Hörverlust, kognitiven Beeinträchtigungen und Epilepsie."},"es":{"name":"Meningitis neumocócica","definition":"Es una enfermedad infecciosa del sistema nervioso poco frecuente producida por la bacteria <i>Streptococcus pneumoniae</i>, que suele formar parte de la flora bacteriana habitual de la mucosa nasofaríngea. La enfermedad se caracteriza clínicamente por síntomas típicos de la leptomeningitis aguda, tales como fiebre, cefalea, rigidez en el cuello, vómitos y obnubilación. La enfermedad suele ser mortal, y los pacientes que sobreviven suelen presentar secuelas a largo plazo, especialmente déficits neurológicos focales, sordera, afectación cognitiva y epilepsia."},"it":{"name":"Meningite pneumococcica","definition":"Si tratta di una malattia infettiva rara del sistema nervoso, causata dal batterio <i>Streptococcus pneumoniae</i>, che normalmente appartiene alla flora batterica che colonizza la muscosa nasofaringea. Dal punto di vista clinico, la malattia è caratterizzata dai sintomi tipici della leptomeningite acuta, che comprendono la febbre, la cefalea, la rigidità del collo, il vomito e l'obnubilamento della coscienza. La malattia è spesso letale e i pazienti che sopravvivono in genere presentano sequele a lungo termine, in particolare deficit neurologici focali, sordità, deficit cognitivo ed epilessia."},"nl":{"name":"Pneumokokkenmeningitis","definition":"Een zeldzame infectieziekte van zenuwstelsel veroorzaakt door de bacterie <i>Streptococcus pneumoniae</i>, die doorgaans deel uitmaakt van de bacteriële flora die de nasofaryngeale mucosa koloniseert. De ziekte wordt klinisch gekarakteriseerd door typische symptomen van acute leptomeningitis, zoals koorts, hoofdpijn, stijve nek, braken, en bewustzijnsvermindering. Het is vaak fataal, en bij overlevende patiënten vaak vergezeld van restverschijnselen op lange termijn, vooral focale neurologische defecten, gehoorverlies, cognitieve functiestoornis, en epilepsie."},"pt":{"name":"Meningite pneumocócica"},"pl":{"name":"Pneumokokowe zapalenie opon mózgowych"},"cs":{"name":"Pneumokoková meningitida"},"uk":{"name":"Пневмококовий менінгіт","definition":"A rare infectious disease of the nervous system caused by the bacterium Streptococcus pneumoniae, which is commonly part of the bacterial flora colonizing the nasopharyngeal mucosa. The disease is clinically characterized by typical symptoms of acute leptomeningitis, like fever, headache, neck stiffness, vomiting, and clouding of consciousness. It is frequently fatal and, in surviving patients, often accompanied by long-term sequelae, especially focal neurological deficits, hearing loss, cognitive impairment, and epilepsy."},"zh":{"name":"肺炎球菌性脑膜炎"},"tr":{"name":"Pnömokok menenjit"}},"xrefs":[{"source":"ICD-10","code":"G00.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B53","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"879178398"},{"source":"MONDO","code":"0006913","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008586","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0025295","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10027253","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98010,"name":"Infectious disease of the nervous system","classifications":[181]},{"orpha":166490,"name":"Infectious disease with epilepsy","classifications":[181]},{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}