{"orpha":533,"name":"Listeriosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Listeria infection"],"definition":"A rare bacterial infectious disease caused by the foodborne pathogen <i>Listeria monocytogenes</i>, characterized by a febrile gastroenteritis, which is usually mild and self-limiting in otherwise healthy persons, but can progress to severe illness in at-risk groups like pregnant women, elderly people, immunocompromised people, and neonates. Complications include sepsis, meningitis, and encephalitis. Listeriosis during pregnancy usually occurs during the third trimester and may lead to preterm labor, miscarriage, stillbirth, or intrauterine infection of the unborn child.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-533/","orphanet_url":"https://www.orpha.net/en/disease/detail/533","names":{"fr":{"name":"Listériose","definition":"Maladie infectieuse bactérienne rare causée par l'agent pathogène d'origine alimentaire <i>Listeria monocytogenes</i>, caractérisée par une gastro-entérite fébrile, qui est généralement bénigne et se résorbe spontanément chez les personnes en bonne santé, mais qui peut évoluer vers une maladie sévère chez les groupes à risque, tels que les femmes enceintes, les personnes âgées, les personnes immunodéprimées et les nouveau-nés. Les complications comprennent la septicémie, la méningite et l'encéphalite. Pendant la grossesse, la listériose survient généralement au cours du troisième trimestre et peut déclencher le travail prématuré, une fausse couche, une mortinaissance ou une infection intra-utérine chez l'enfant à naître."},"de":{"name":"Listeriose","synonyms":["Listerien-Infektion"],"definition":"Eine seltene bakterielle Infektionskrankheit, die durch den durch Lebensmittel übertragenen Erreger <i>Listeria monocytogenes</i> verursacht wird und durch eine fiebrige Gastroenteritis gekennzeichnet ist, die bei ansonsten gesunden Personen in der Regel mild und selbstlimitierend verläuft, bei Risikogruppen wie Schwangeren, älteren Menschen, immungeschwächten Personen und Neugeborenen jedoch zu einer schweren Erkrankung führen kann. Zu den Komplikationen gehören Sepsis, Meningitis und Enzephalitis. Eine Listeriose während der Schwangerschaft tritt in der Regel im dritten Trimester auf und kann zu vorzeitigen Wehen, einer Fehlgeburt, einer Totgeburt oder einer intrauterinen Infektion des ungeborenen Kindes führen."},"es":{"name":"Listeriosis","synonyms":["Infección por listeria"],"definition":"Es una enfermedad infecciosa bacteriana poco frecuente causada por el patógeno alimentario <i>Listeria monocytogenes</i>. Está caracterizada por gastroenteritis febril, que suele ser leve y autolimitada en individuos sanos, aunque puede progresar a enfermedad grave en grupos de riesgo tales como las gestantes, los individuos de edad avanzada o inmunocomprometidos y los neonatos. Las complicaciones incluyen sepsis, meningitis y encefalitis. La listeriosis durante el embarazo ocurre, por lo general, durante el tercer trimestre y puede resultar en parto prematuro, aborto espontáneo, mortinatalidad o infección fetal intrauterina."},"it":{"name":"Listeriosi","definition":"Si tratta di un'infezione batterica rara, causata dal patogeno <i>Listeria monocytogenes</i> trasmesso con gli alimenti. È caratterizzata da gastroenterite febbrile, che di solito è lieve e autolimitante nei soggetti sani, ma che può progredire verso la malattia grave nelle persone a rischio, come le donne in gravidanza, gli anziani, i soggetti immunocompromessi e i neonati. Le complicanze comprendono la sepsi, la meningite e l'encefalite. In gravidanza la listeriosi di solito esordisce nel terzo trimestre e può causare il parto pretermine, l'aborto, la morte perinatale o l'infezione fetale."},"nl":{"name":"Listeriose","synonyms":["Listeria-infectie"],"definition":"Een zeldzame, bacteriële infectieuze aandoening veroorzaakt door de door voedsel overgedragen pathogeen <i>Listeria monocytogenes</i>, en gekarakteriseerd door febriele gastro-enteritis, die meestal mild en zelflimiterend is bij voor het overige gezonde personen, maar die kan evolueren tot ernstige ziekte bij groepen die risico lopen, zoals zwangere vrouwen, oudere mensen, immuungecompromitteerde mensen, en neonaten. Complicaties zijn onder meer sepsis, meningitis, en encefalitis. Listeriose tijdens de zwangerschap komt meestal voor tijdens het derde trimester en kan leiden tot premature weeën, miskraam, doodgeboorte, of intra-uteriene infectie van het ongeboren kind."},"pt":{"name":"Listeriose"},"pl":{"name":"Listerioza","synonyms":["Listeria infection"]},"cs":{"name":"Listerióza","synonyms":["Listeria infection"]},"uk":{"name":"Лістеріоз","synonyms":["Лістеріозна інфекція"],"definition":"A rare bacterial infectious disease caused by the foodborne pathogen <i>Listeria monocytogenes</i>, characterized by a febrile gastroenteritis, which is usually mild and self-limiting in otherwise healthy persons, but can progress to severe illness in at-risk groups like pregnant women, elderly people, immunocompromised people, and neonates. Complications include sepsis, meningitis, and encephalitis. Listeriosis during pregnancy usually occurs during the third trimester and may lead to preterm labor, miscarriage, stillbirth, or intrauterine infection of the unborn child."},"zh":{"name":"李斯特氏菌病","synonyms":["李斯特菌感染"]},"tr":{"name":"Listerioz","synonyms":["Listeria enfeksiyonu"]}},"xrefs":[{"source":"ICD-10","code":"A32.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A32.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A32.7","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A32.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A32.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C1A","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"419706488"},{"source":"ICD-11","code":"1C1A.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1789950491"},{"source":"ICD-11","code":"1C1A.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"268154767"},{"source":"ICD-11","code":"1C1A.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0005828","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008088","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5886852","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6915","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10024641","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.337,"area":"Worldwide","status":"Validated","source":"25241232[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.31,"area":"United States","status":"Validated","source":"17243053[PMID]_CDC Centers for disease Control and prevention 1996-2003[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.43,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.48,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.07,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.09,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.36,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.98,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.4,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.1,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.57,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.68,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.15,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.28,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.29,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2015-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.31,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.67,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.9,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.92,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.56,"area":"Iceland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.46,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.29,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.24,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.28,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.25,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.4,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.38,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.47,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.23,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2016[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-03","source":"31837132[PMID]_25241232[PMID]_8994747[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010987","label":"Abnormal cellular immune system morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031864","label":"Bacteremia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011972","label":"Hypoglycorrhachia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100022","label":"Abnormality of movement","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000236","label":"Abnormality of the anterior fontanelle","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025615","label":"Abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001251","label":"Ataxia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030049","label":"Brain abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002955","label":"Granulomatosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001269","label":"Hemiparesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007185","label":"Loss of consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001336","label":"Myoclonus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031179","label":"Nuchal rigidity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001622","label":"Premature birth","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012330","label":"Pyelonephritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003474","label":"Somatic sensory dysfunction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012747","label":"Abnormal brainstem MRI signal intensity","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012089","label":"Arteritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001082","label":"Cholecystitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000365","label":"Hearing impairment","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011955","label":"Hepatic granulomatosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001249","label":"Intellectual disability","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007432","label":"Intermittent generalized erythematous papular rash","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100523","label":"Liver abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0200039","label":"Pustule","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003095","label":"Septic arthritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025059","label":"Splenic abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032162","label":"Unusual skin infection","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000572","label":"Visual loss","frequency":"Very rare (<4-1%)","criteria":null}]}}