{"orpha":525738,"name":"Prepubertal anorexia nervosa","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare neurologic disease with psychiatric involvement characterized by significantly lower-than-expected body weight due to voluntary reduction of food intake, intense fear of becoming overweight, and a distorted body image, in prepubescent children. Secondary manifestations include growth, developmental, and pubertal delay, decreased bone density, severe metabolic and endocrine dysfunction, cognitive impairment, depression, deterioration of academic or athletic performance, as well as difficulties in familial and peer relations, among others.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-525738/","orphanet_url":"https://www.orpha.net/en/disease/detail/525738","names":{"fr":{"name":"Anorexie mentale de l'enfant","definition":"Maladie neurologique rare avec atteinte psychiatrique caractérisée par un poids significativement plus faible par rapport à la normale, dû à une diminution volontaire de l'apport alimentaire, une peur intense de devenir obèse et une dysmorphophobie chez l'enfant prépubère. Les manifestations secondaires sont un retard de croissance, de développement et de la puberté, une diminution de la densité osseuse, un dysfonctionnement endocrinien et métabolique sévère, des troubles cognitifs, une dépression, une détérioration des résultats académiques et sportifs, ainsi que des difficultés relationnelles dans la sphère familiale et amicale, entre autres."},"de":{"name":"Anorexia nervosa, präpubertäre","definition":"Eine seltene neurologische Erkrankung mit psychiatrischer Beteiligung, die bei vorpubertären Kindern durch ein deutlich geringeres Körpergewicht als erwartet gekennzeichnet ist, da sie freiwillig die Nahrungsaufnahme reduzieren, starke Angst vor Übergewicht haben und ein verzerrtes Körperbild haben. Zu den sekundären Manifestationen gehören unter anderem Wachstums-, Entwicklungs- und Pubertätsverzögerungen, verminderte Knochendichte, schwere Stoffwechsel- und endokrine Funktionsstörungen, kognitive Beeinträchtigungen, Depressionen, Verschlechterung der schulischen oder sportlichen Leistungen sowie Schwierigkeiten in familiären und gleichaltrigen Beziehungen."},"es":{"name":"Anorexia nerviosa prepuberal","definition":"Es una enfermedad neurológica poco frecuente con afectación psiquiátrica caracterizada por un peso corporal significativamente menor al esperado debido a la reducción voluntaria de la ingesta de alimentos, el miedo intenso a padecer sobrepeso y una imagen corporal distorsionada en niños prepúberes. Otras manifestaciones secundarias adicionales incluyen retraso puberal, psicomotor y en el crecimiento, disminución de la densidad ósea, grave disfunción metabólica y endocrina, deterioro cognitivo, depresión, deterioro del rendimiento académico o atlético, así como problemas en las relaciones familiares y con los compañeros, entre otras."},"it":{"name":"Anoressia nervosa prepuberale","definition":"Si tratta di una malattia neurologica rara con interessamento psichiatrico, caratterizzata da un peso significativamente inferiore alla norma, causato dalla riduzione volontaria dell'assunzione di cibo, dalla paura del sovrappeso e da un'immagine distorta del corpo, nei bambini in età prepuberale. I sintomi secondari comprendono il ritardo della crescita, dello sviluppo e della pubertà, la diminuzione della densità ossea, la grave disfunzione metabolica ed endocrina, il deficit cognitivo, la depressione, il peggioramento dei risultati scolastici o nello sport, e le difficoltà nei rapporti con i familiari e con i coetanei."},"nl":{"name":"Prepuberale anorexia nervosa","definition":"Een zeldzame neurologische aandoening met psychiatrische betrokkenheid, gekarakteriseerd door significant lager dan verwacht lichaamsgewicht als gevolg van vrijwillig verminderde voedingsinname, intense angst voor overgewicht, en een verstoord lichaamsbeeld, bij prepuberale kinderen. Secundaire manifestaties zijn onder meer vertraagde groei, ontwikkeling en puberteit, verlaagde botdensiteit, ernstige metabole en endocriene disfunctie, cognitieve functiestoornis, depressie, achteruitgang van academische of atletische prestaties, alsook moeilijkheden met relaties met familie en gelijken."},"pt":{"name":"Anorexia nervosa pré-pubertária"},"pl":{"name":"Jadłowstręt psychiczny w okresie przedpokwitaniowym/anorexia nervosa w okresie przedpokwitaniowym"},"cs":{"name":"Předpubertální mentální anorexie"},"uk":{"name":"Нервова анорексія в препубертатному віці","definition":"A rare neurologic disease with psychiatric involvement characterized by significantly lower-than-expected body weight due to voluntary reduction of food intake, intense fear of becoming overweight, and a distorted body image, in prepubescent children. Secondary manifestations include growth, developmental, and pubertal delay, decreased bone density, severe metabolic and endocrine dysfunction, cognitive impairment, depression, deterioration of academic or athletic performance, as well as difficulties in familial and peer relations, among others."},"zh":{"name":"青春期前神经性厌食","definition":"一种罕见的神经系统疾病，伴有精神疾病，其特点是青春期前儿童由于自愿减少食物摄入量而导致体重明显低于预期，强烈恐惧超重，身体意象扭曲。次要表现包括生长、发育和青春期延迟、骨密度降低、严重的代谢和内分泌功能障碍、认知障碍、抑郁症、学习或运动成绩下降，以及家庭和同伴关系困难等。"},"tr":{"name":"Prepubertal anoreksiya nervoza"}},"xrefs":[{"source":"ICD-10","code":"F50.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0033926","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5568567","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":181384,"name":"Rare hypothalamic or pituitary disease","classifications":[193]},{"orpha":98033,"name":"Rare neurologic disease with psychiatric involvement","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}