{"orpha":521123,"name":"Radiation-induced plexopathy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare radiation-induced disorder characterized by impairment of the peripheral nervous system at the level of the brachial or lumbosacral plexus following radiation therapy. Onset of symptoms can occur between several months up to decades after the last dose of radiation. Patients with radiation-induced brachial plexopathy typically present with mostly unilateral progressive paresthesia, followed by weakness, atrophy, and pain. Symptoms in radiation-induced lumbosacral plexopathy include more variable combinations of numbness, paresthesia, pain, and weakness, and are more often bilateral.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-521123/","orphanet_url":"https://www.orpha.net/en/disease/detail/521123","names":{"fr":{"name":"Plexopathie radio-induite","definition":"Maladie radio-induite rare, caractérisée par une atteinte du système nerveux périphérique au niveau du plexus brachial ou lombosacré à la suite d'une radiothérapie. Les symptômes peuvent apparaître entre plusieurs mois à plusieurs décennies après la dernière dose de radiation reçue. Les patients atteints de plexopathie brachiale radio-induite présentent généralement une paresthésie progressive essentiellement unilatérale, suivie d'une faiblesse, d'une atrophie et de douleurs. Les symptômes de la plexopathie lombosacrée radio-induite comprennent des associations plus variables d'engourdissement, de paresthésie, de douleur et de faiblesse, et sont plus souvent bilatéraux."},"de":{"name":"Strahleninduzierte Plexopathie","definition":"Eine seltene strahleninduzierte Erkrankung, die durch eine Beeinträchtigung des peripheren Nervensystems auf der Ebene des Plexus brachialis oder lumbosakralis nach einer Strahlentherapie gekennzeichnet ist. Die ersten Symptome können mehrere Monate bis Jahrzehnte nach der letzten Strahlendosis auftreten. Patienten mit strahleninduzierter Plexus brachialis zeigen typischerweise eine meist einseitige, progressive Parästhesie, gefolgt von Schwäche, Atrophie und Schmerzen. Die Symptome der strahleninduzierten lumbosakralen Plexopathie umfassen variablere Kombinationen von Taubheit, Parästhesien, Schmerzen und Schwäche und treten häufiger beidseitig auf."},"es":{"name":"Plexopatía inducida por radiación","definition":"Es un trastorno poco frecuente inducido por radiación caracterizado por el deterioro del sistema nervioso periférico a nivel del plexo braquial o lumbosacro después de la radioterapia. Los síntomas pueden aparecer varios meses o décadas después de la última dosis de radiación. Los pacientes con plexopatía braquial inducida por radiación suelen presentarse con un cuadro de parestesias progresivas principalmente unilateral, seguido de debilidad, atrofia y dolor. Los síntomas de la plexopatía lumbosacra inducida por radiación incluyen combinaciones más variables de adormecimiento, parestesias, dolor y debilidad, con mayor frecuencia, bilaterales."},"it":{"name":"Plessopatia indotta dalle radiazioni","definition":"Si tratta di una malattia rara indotta dalle radiazioni, caratterizzata dalla compromissione del sistema nervoso periferico a livello del plesso brachiale o lombosacrale secondaria alla radioterapia. I sintomi possono manifestarsi da alcuni mesi fino a decenni dopo l'ultima seduta di radioterapia. Di solito i pazienti presentano parestesie progressive per lo più monolaterali, seguite da debolezza, atrofia e dolore. I sintomi comprendono in maniera variabile l'insensibilità, le parestesie, il dolore e la debolezza, e in genere sono bilaterali."},"nl":{"name":"Stralingsgeïnduceerde plexopathie","synonyms":["Radiatiegeïnduceerde plexopathie"],"definition":"Een zeldzame door straling geïnduceerde aandoening, gekarakteriseerd door verstoring van perifeer zenuwstelsel ter hoogte van brachiale of lumbosacrale plexus na radiotherapie. Aanvang van symptomen kan plaatsvinden vanaf enkele maanden tot decennia na de laatste stralingsdosis. Patiënten met stralingsgeïnduceerde brachiale plexopathie presenteren zich doorgaans met overwegend unilaterale progressieve paresthesie, gevolgd door zwakte, atrofie, en pijn. Symptomen bij stralingsgeïnduceerde lumbosacrale plexopathie omvatten meer variabele combinaties van gevoelloosheid, paresthesie, pijn, en zwakte, en zijn vaker bilateraal."},"pt":{"name":"Plexopatia induzida por radiação"},"pl":{"name":"Porażenie splotu nerwowego po radioterapii"},"cs":{"name":"Plexopatie vyvolaná radiací"},"uk":{"name":"Променева плексопатія","definition":"A rare radiation-induced disorder characterized by impairment of the peripheral nervous system at the level of the brachial or lumbosacral plexus following radiation therapy. Onset of symptoms can occur between several months up to decades after the last dose of radiation. Patients with radiation-induced brachial plexopathy typically present with mostly unilateral progressive paresthesia, followed by weakness, atrophy, and pain. Symptoms in radiation-induced lumbosacral plexopathy include more variable combinations of numbness, paresthesia, pain, and weakness, and are more often bilateral."},"zh":{"name":"辐射诱导的神经丛病","definition":"一种罕见的辐射引起的疾病，其特征是放疗后臂丛或腰骶丛水平的周围神经系统受损。症状可在最后一次放射剂量后数月至数十年内出现。放射诱导的臂神经丛病患者通常大多表现为单侧进行性麻木，然后是无力、萎缩和疼痛。辐射引起的腰骶神经丛病的症状包括更多的混合型麻木、麻痹、疼痛和无力，而且更多的是双侧。"},"tr":{"name":"Radyasyonla indüklenen pleksopati"}},"xrefs":[{"source":"ICD-10","code":"G54.0","qualifier":"NTBT","icd_relation":"attributed","validated":false},{"source":"ICD-11","code":"8B91.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"605374423"},{"source":"MONDO","code":"0033838","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5681446","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":182086,"name":"Acquired peripheral neuropathy","classifications":[181]},{"orpha":521132,"name":"Radiation-induced disorder","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}