{"orpha":519930,"name":"Fungal keratitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Keratomycosis","Mycotic keratitis"],"definition":"A rare disorder of the anterior segment of the eye characterized by ocular infection by human-pathogenic fungi, most commonly <i>Aspergillus</i>, <i>Candida</i>, or <i>Fusarium</i> species, which gain access into the corneal stroma through a defect in the corneal epithelium. Risk factors include trauma, ocular surface disease, contact lenses, or immunocompromised state. Patients present with pain, foreign body sensation, redness, photophobia, tearing, secretion, or blurred vision. The condition may be complicated by corneal destruction and perforation, endophthalmitis, scleritis, and panophthalmitis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-519930/","orphanet_url":"https://www.orpha.net/en/disease/detail/519930","names":{"fr":{"name":"Kératite fongique","synonyms":["Kératite mycosique","Kératomycose"],"definition":"Maladie rare du segment antérieur de l'oeil caractérisée par une infection oculaire par des champignons pathogènes pour l'Homme, le plus souvent par les espèces <i>Aspergillus</i>, <i>Candida</i>, ou <i>Fusarium</i>, qui pénètrent le stroma cornéen en raison d'un défaut de l'épithélium cornéen. Les facteurs de risque sont les traumatismes, les maladies de la surface oculaire, les lentilles de contact ou l'état d'immunodépression. Les patients présentent une douleur, une sensation de corps étranger, une rougeur, une photophobie, un larmoiement, une sécrétion ou des troubles de vision. La destruction et la perforation de la cornée, une endophtalmie, une sclérite et une panophtalmie sont des complications possibles."},"de":{"name":"Keratitis, mykotische","synonyms":["Keratomykose","Pilz-Keratitis"],"definition":"Eine seltene Erkrankung des vorderen Augensegments, die durch eine Augeninfektion mit humanpathogenen Pilzen, meist <i>Aspergillus</i>-, <i>Candida</i>- oder <i>Fusarium</i>-Arten, gekennzeichnet ist, die durch einen Defekt des Hornhautepithels in das Hornhautstroma eindringen. Zu den Risikofaktoren gehören Traumata, Erkrankungen der Augenoberfläche, Kontaktlinsen oder ein geschwächter Zustand des Immunsystems. Die Patienten leiden unter Schmerzen, Fremdkörpergefühl, Rötung, Photophobie, Tränenfluss, Sekretion oder verschwommenem Sehen. Die Erkrankung kann durch Hornhautzerstörung und -perforation, Endophthalmitis, Skleritis und Panophthalmitis kompliziert werden."},"es":{"name":"Queratitis fúngica","synonyms":["Queratitis micótica","Queratomicosis"],"definition":"Es un trastorno poco frecuente del segmento anterior del ojo caracterizado por una infección ocular por hongos patógenos de humanos, más comúnmente por especies de <i>Aspergillus</i>, <i>Candida</i> o <i>Fusarium</i>, que acceden al estroma corneal a través de un defecto en el epitelio corneal. Los factores de riesgo incluyen trauma, enfermedad de la superficie ocular, lentes de contacto o estado inmunodeprimido. Los pacientes presentan dolor, sensación de cuerpo extraño, enrojecimiento, fotofobia, lagrimeo, secreción o visión borrosa. La afección puede complicarse por destrucción y perforación de la córnea, endoftalmitis, escleritis y panoftalmitis."},"it":{"name":"Cheratite micotica","definition":"Si tratta di una malattia rara del segmento anteriore dell'occhio, caratterizzata da un'infezione oculare da funghi patogeni per l'uomo, spesso delle specie <i>Aspergillus</i>, <i>Candida</i> o <i>Fusarium</i>, che raggiungono lo stroma della cornea attraverso un difetto nell'epitelio corneale. Sono fattori di rischio i traumi, le malattie della superficie oculare, l'uso delle lenti a contatto e l'immunodeficienza. I pazienti presentano dolore, sensazione di corpo estraneo, arrossamento, fotofobia, lacrimazione, secrezione e visione offuscata. La malattia può associarsi a complicanze quali la distruzione e la perforazione della cornea, l'endoftalmite, la sclerite e la panoftalmite."},"nl":{"name":"Fungale keratitis","synonyms":["Keratitis door schimmel","Keratomycose","Mycotische keratitis"],"definition":"Een zeldzame aandoening van voorste oogsegment, gekarakteriseerd door infectie van oog door humane pathogene schimmels, doorgaans soorten van de geslachten <i>Aspergillus</i>, <i>Candida</i> of <i>Fusarium</i>, die toegang krijgen tot stroma van cornea door een defect van cornea-epitheel. Risicofactoren zijn onder meer trauma, aandoening van oogoppervlak, contactlenzen, of immuungecompromitteerde toestand. Patiënten present eren zich met pijn, gevoel van corpus alienum, roodheid, fotofobie, tranende ogen, secretie, of troebel zicht. De aandoening kan gecompliceerd worden door destructie en perforatie van hoornvlies, endoftalmitis, scleritis, en panoftalmitis."},"pt":{"name":"Queratite fúngica"},"pl":{"name":"Grzybicze zapalenie rogówki","synonyms":["Keratomycosis","Mycotic keratitis"]},"cs":{"name":"Mykotická keratitida","synonyms":["Keratomycosis","Mycotic keratitis"]},"uk":{"name":"Грибковий кератит","synonyms":["Кератомікоз","Мікотичний кератит"],"definition":"A rare disorder of the anterior segment of the eye characterized by ocular infection by human-pathogenic fungi, most commonly <i>Aspergillus</i>, <i>Candida</i>, or <i>Fusarium</i> species, which gain access into the corneal stroma through a defect in the corneal epithelium. Risk factors include trauma, ocular surface disease, contact lenses, or immunocompromised state. Patients present with pain, foreign body sensation, redness, photophobia, tearing, secretion, or blurred vision. The condition may be complicated by corneal destruction and perforation, endophthalmitis, scleritis, and panophthalmitis."},"zh":{"name":"真菌性角膜炎","synonyms":["Keratomycosis","Mycotic keratitis"]},"tr":{"name":"Mantar keratiti","synonyms":["Keratomikoz","Mikotik keratit"]}},"xrefs":[{"source":"ICD-10","code":"B49+","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-10","code":"H19.2*","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"9A71","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"712798367"},{"source":"MONDO","code":"0033821","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1262117","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10062353","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97966,"name":"Rare ophthalmic disorder"},"parents":[{"orpha":519278,"name":"Infective keratitis","classifications":[189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}