{"orpha":50839,"name":"Cat-scratch disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Bartonellosis due to Bartonella henselae infection"],"definition":"Cat-scratch disease is a rare infectious disease, caused by the Gram-negative bacteria <i>Bartonella henselae</i>, that is transmitted to humans via a scratch or bite of an infected cat and that has a variable clinical presentation but that usually manifests with an erythematous papule at the site of inoculation followed by chronic regional lymphadenopathy. Clinical course is usually self-limiting but disseminated illness with high fever, hepatosplenomegaly, granulomatous osteolytic lesions, encephalitis, retinitis, and atypical pneumonia can also occur. Cat-scratch disease can atypically present as parinaud oculoglandular syndrome (unilateral conjunctivitis and preauricular lymphadenopathy).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-50839/","orphanet_url":"https://www.orpha.net/en/disease/detail/50839","names":{"fr":{"name":"Maladie des griffes du chat","synonyms":["Bartonellose à Bartonella henselae"],"definition":"Maladie infectieuse rare, causée par la bactérie Gram-négative <i>Bartonella henselae</i>, transmise à l'homme par la griffure ou la morsure d'un chat infecté. Le tableau clinique est variable, mais se caractérise généralement par l'apparition d'une papule érythémateuse au site d'inoculation, suivie d'une lymphadénopathie locale chronique. L'évolution clinique est généralement spontanément résolutive, mais un malaise généralisé avec forte fièvre, hépatosplénomégalie, lésions ostéolytiques granulomateuses, encéphalite, rétinite et pneumonie atypique peut également survenir. La maladie des griffes du chat peut se manifester de manière atypique sous la forme d'un syndrome oculoglandulaire de Parinaud (conjonctivite unilatérale et lymphadénopathie préauriculaire)."},"de":{"name":"Katzenkratzkrankheit","synonyms":["Bartonellose durch Infektion mit Bartonella henselae"],"definition":"Die Katzenkratzkrankheit ist eine seltene, durch das gramnegative Bakterium <I>Bartonella henselae</I> verursachte Infektionskrankheit, die durch Kratzen oder Biss einer infizierten Katze auf den Menschen übertragen wird und ein unterschiedliches klinisches Erscheinungsbild aufweist, das sich jedoch in der Regel durch eine erythematöse Papel an der Inokulationsstelle und eine anschließende chronische regionale Lymphadenopathie äußert. Der klinische Verlauf ist in der Regel selbstlimitierend, doch können auch disseminierte Erkrankungen mit hohem Fieber, Hepatosplenomegalie, granulomatösen osteolytischen Läsionen, Enzephalitis, Retinitis und atypischer Pneumonie auftreten. Atypische Verläufe sind charakterisiert durch neurologische Symptome (Enzephalitis, periphere Neuropathie, Augensymptome [okulo-glanduläres Syndrom Parinaud]), Lungenbeteiligung, kardiovaskuläre Störungen, Hepatomegalie, thrombozytopenische Purpura und Erythema nodosum"},"es":{"name":"Enfermedad por arañazo de gato","definition":"Es una enfermedad infecciosa poco frecuente, causada por la bacteria Gram-negativa <i>Bartonella henselae</i>, que se transmite a los humanos a través de un rasguño o mordedura de un gato infectado con esta bacteria. Tiene una presentación clínica variable pero, por lo general, se manifiesta mediante una pápula eritematosa en el lugar de la inoculación seguida de linfadenopatía regional crónica. El curso clínico de la enfermedad suele ser autolimitado, pero en ciertos casos puede haber una diseminación de la enfermedad ocasionando fiebre alta, hepatoesplenomegalia, lesiones osteolíticas granulomatosas, encefalitis, retinitis y neumonía atípica. La enfermedad por arañazo de gato también puede presentarse atípicamente como un síndrome oculoglandular de Parinaud (conjuntivitis unilateral y linfadenopatía preauricular)."},"it":{"name":"Malattia del graffio di gatto","synonyms":["Bartonellosi dovuta a infezione da Bartonella henselae"],"definition":"La malattia del graffio di gatto è una malattia infettiva rara, causata da un batterio Gram-negativo, la Bartonella henselae, trasmessa all'uomo attraverso il graffio o il morso di un gatto infetto. Il quadro clinico è variabile, ma di solito è caratterizzato dalla comparsa di una papula eritematosa nel sito di inoculazione, seguita da una linfoadenopatia locale cronica. Il decorso clinico è in genere autolimitante, ma può insorgere un malessere diffuso con febbre alta, epatosplenomegalia, lesioni osteolitiche granulomatose, encefalite, retinite e polmonite atipica. La malattia del graffio di gatto può manifestarsi in maniera atipica sotto forma di sindrome oculoghiandolare di Parinaud (congiuntivite monolaterale e linfoadenopatia preauricolare)."},"nl":{"name":"Kattenkrabziekte","synonyms":["Bartonellosis als gevolg van Bartonella henselae-infectie"],"definition":"Kattenkrabziekte is een zeldzame infectieziekte die wordt veroorzaakt door de Gram-negatieve bacterie <i>Bartonella henselae</i>, en die wordt overgedragen op mensen via een krab of beet van een geïnfecteerde kat. De ziekte vertoont een variabel klinisch beeld maar manifesteert zich meestal met een erythemateuze papel ter hoogte van de plaats van inoculatie, gevolgd door chronische regionale lymfadenopathie. Het klinisch verloop is doorgaans zelflimiterend, maar gedissemineerde ziekte met hoge koorts, hepatosplenomegalie, granulomateuze osteolytische letsels, encefalitis, retinitis, en atypische pneumonie kan ook voorkomen. Kattenkrabziekte kan atypisch voorkomen als oculoglandulair syndroom van Parinaud (unilaterale conjunctivitis en pre-auriculaire lymfadenopathie)."},"pt":{"name":"Doença da arranhadela do gato","synonyms":["Bartonelose por infeção por Bartonella henselae"]},"pl":{"name":"Choroba kociego pazura","synonyms":["Bartonelloza spowodowana infekcją Bartonella henselae"]},"cs":{"name":"Nemoc z kočičího škrábnutí","synonyms":["Bartonellóza způsobená infekcí bakterií Bartonella henselae"]},"uk":{"name":"Хвороба котячих подряпин","synonyms":["Бартонельоз, спричинений інфекцією Bartonella henselae"],"definition":"Cat-scratch disease is a rare infectious disease, caused by the Gram-negative bacteria <i>Bartonella henselae</i>, that is transmitted to humans via a scratch or bite of an infected cat and that has a variable clinical presentation but that usually manifests with an erythematous papule at the site of inoculation followed by chronic regional lymphadenopathy. Clinical course is usually self-limiting but disseminated illness with high fever, hepatosplenomegaly, granulomatous osteolytic lesions, encephalitis, retinitis, and atypical pneumonia can also occur. Cat-scratch disease can atypically present as parinaud oculoglandular syndrome (unilateral conjunctivitis and preauricular lymphadenopathy)."},"zh":{"name":"猫抓病","synonyms":["巴尔通体属感染所致巴尔通体病"]},"tr":{"name":"Kedi tırmığı hastalığı","synonyms":["Bartonella henselae enfeksiyonuna bağlı bartonelloz"]}},"xrefs":[{"source":"ICD-10","code":"A28.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B98","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2003001085"},{"source":"MONDO","code":"0005692","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002372","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0007361","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"27","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10007729","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":6.6,"area":"Europe","status":"Validated","source":"[EXPERT]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-07-05","source":"29489252[PMID]_26161064[PMID]_21243990[PMID]","terms":[{"hpo":"HP:0030350","label":"Erythematous papule","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033834","label":"Malaise","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0020161","label":"Branch retinal artery occlusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0020165","label":"Branch retinal vein occlusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003565","label":"Elevated erythrocyte sedimentation rate","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001433","label":"Hepatosplenomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100653","label":"Optic neuritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012121","label":"Panuveitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000541","label":"Retinal detachment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032118","label":"Retinitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0033430","label":"Non-infectious meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very rare (<4-1%)","criteria":null}]}}