{"orpha":498251,"name":"Menstrual cycle-dependent periodic fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Luteal-phase-dependent febrile episode","Luteal-phase-dependent periodic fever","Menstrual cycle-dependent febrile episode"],"definition":"A rare anomaly of puberty or/and menstrual cycle characterized by recurrent fevers (higher than 38 degrees Celsius) associated with the luteal phase of the menstrual cycle in women.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-498251/","orphanet_url":"https://www.orpha.net/en/disease/detail/498251","names":{"fr":{"name":"Fièvre récurrente cycle menstruel-dépendante","synonyms":["Episode fébrile cycle menstruel-dépendant","Fièvre périodique cycle menstruel-dépendante","Fièvre périodique phase lutéale-dépendante","Fièvre récurrente phase lutéale-dépendante"],"definition":"Anomalie rare du cycle menstruel et/ou de la puberté caractérisée par des fièvres récurrentes (supérieures à 38°C) associées à la phase lutéale du cycle menstruel chez la femme."},"de":{"name":"Periodisches Fieber, Menstruationszyklus-abhängiges","synonyms":["Febrile Episode, Luteal-Phase-abhängige","Febrile Episode, Menstruationszyklus-abhänginge","Periodisches Fieber, Luteal-Phase-abhängiges"],"definition":"Eine seltene Anomalie der Pubertät oder/und des Menstruationszyklus, die durch wiederkehrendes Fieber (über 38 Grad Celsius) in Verbindung mit der Lutealphase des Menstruationszyklus bei Frauen gekennzeichnet ist."},"es":{"name":"Fiebre periódica dependiente del ciclo menstrual","synonyms":["Episodio febril dependiente de la fase luteal","Episodio febril dependiente del ciclo menstrual","Fiebre periódica dependiente de la fase luteal"],"definition":"Es una anomalía poco frecuente de la pubertad y/o del ciclo menstrual caracterizada por fiebre recurrente (superior a 38oC) asociada con la fase lútea del ciclo menstrual en mujeres."},"it":{"name":"Febbre periodica correlata al ciclo mestruale","definition":"Si tratta di un'anomalia rara della pubertà e/o del ciclo mestruale caratterizzata da episodi febbrili ricorrenti (temperatura superiore ai 38°C) associati alla fase luteinica del ciclo mestruale nelle femmine."},"nl":{"name":"Menstruatiecyclus-afhankelijke periodieke koorts","synonyms":["Luteale fase-afhankelijke febriele episode","Luteale fase-afhankelijke periodieke koorts","Menstruatiecyclus-afhankelijke febriele episode"],"definition":"Een zeldzame anomalie van puberteit en/of menstruatiecyclus, gekarakteriseerd door terugkerende koorts (hoger dan 38 graden Celsius), geassocieerd met de luteale fase van de menstruatiecyclus bij vrouwen."},"pt":{"name":"Febre periódico dependente do ciclo menstrual"},"pl":{"name":"Gorączka periodyczna zależna od cyklu miesięcznego","synonyms":["Gorączka periodyczna zależna od fazy lutealnej","Epizod gorączki zależnej od fazy lutealnej","Epizod gorączki zależnej od cyklu miesiączkowego"]},"cs":{"name":"Periodické horečky závislé na menstruačním cyklu","synonyms":["Luteal-phase-dependent periodic fever","Luteal-phase-dependent febrile episode","Menstrual cycle-dependent febrile episode","Periodická horečka závislá na luteální fázi","Febrilní epizoda závislá na luteální fázi","Febrilní epizoda závislá na menstruačním cyklu"]},"uk":{"name":"Залежна від менструального циклу періодична лихоманка","synonyms":["Залежний від лютеїнової фази гарячковий епізод","Залежна від лютеїнової фази періодична лихоманка","Залежний від менструального циклу гарячковий епізод"],"definition":"A rare anomaly of puberty or/and menstrual cycle characterized by recurrent fevers (higher than 38 degrees Celsius) associated with the luteal phase of the menstrual cycle in women."},"zh":{"name":"月经周期相关的周期性发热","synonyms":["Luteal-phase-dependent febrile episode","Luteal-phase-dependent periodic fever","Menstrual cycle-dependent febrile episode"],"definition":"一种罕见的青春期或（和）月经周期的异常现象，其特点是反复发烧（高于38摄氏度），与女性月经周期的黄体期有关。"},"tr":{"name":"Adet döngüsüne bağlı periyodik ateş","synonyms":["Luteal faza bağımlı periyodik ateş","Luteal faza bağlı ateşli epizod","Menstrüal döngüsüne bağlı ateşli epizod"]}},"xrefs":[{"source":"OMIM","code":"614674","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"N94.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"GA20.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0044660","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C3553418","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":96344,"name":"Rare gynecologic or obstetric disease"},"parents":[{"orpha":180208,"name":"Anomaly of puberty or/and menstrual cycle","classifications":[205]}],"children":[],"genes":[{"symbol":"HTR1A","name":"5-hydroxytryptamine receptor 1A","gene_type":"gene with protein product","association":"Candidate gene tested in","status":"Not yet assessed","source":"21990073[PMID]","hgnc":"5286","ensembl":"ENSG00000178394","omim":"109760","loci":["5q12.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":5.0,"area":"Worldwide","status":"Validated","source":"7684743[PMID]_16006734[PMID]_21990073[PMID]_21501330[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_7684743[PMID]_16006734[PMID]_21990073[PMID]_21501330[PMID]"}],"phenotypes":null}