{"orpha":48162,"name":"Lewis-Sumner syndrome","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["MADSAM","Multifocal acquired demyelinating sensory and motor neuropathy"],"definition":"A rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of chronic inflammatory demyelinating polyneuropathy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-48162/","orphanet_url":"https://www.orpha.net/en/disease/detail/48162","names":{"fr":{"name":"Syndrome de Lewis-Sumner","synonyms":["Neuropathie démyélinisante multifocale sensitivomotrice acquise"],"definition":"Polyneuropathie démyélinisante acquise rare, caractérisée par une faiblesse distale asymétrique des membres supérieurs ou inférieures et une dysfonction motrice, apparaissant à l'âge adulte. Elle est considérée comme une variante de la polyneuropathie inflammatoire démyélinisante chronique."},"de":{"name":"Lewis-Sumner-Syndrom","synonyms":["MADSAM","Multifokale erworbene demyelinisierende sensorische und motorische Neuropathie"],"definition":"Das Lewis-Sumner-Syndrom (LSS) ist eine seltene erworbene demyelinisierende Polyneuropathie, die durch eine asymmetrische distale Schwäche der oberen oder unteren Extremitäten und eine motorische Dysfunktion mit Beginn im Erwachsenenalter gekennzeichnet ist. Es wird als eine Variante der chronisch entzündlichen demyelinisierenden Polyneuropathie angesehen."},"es":{"name":"Síndrome de Lewis-Summer","definition":"El síndrome de Lewis-Sumner (SLS) es una polineuropatía desmielinizante adquirida poco frecuente caracterizada por debilidad distal asimétrica de las extremidades superiores o inferiores y disfunción motora de aparición en la edad adulta. Se considera una variante de la polineuropatía desmielinizante crónica."},"it":{"name":"Sindrome di Lewis-Sumner","synonyms":["MADSAM"],"definition":"La sindrome di Lewis-Sumner (LSS) è una polineuropatia demielinizzante acquisita rara, caratterizzata da debolezza distale asimmetrica degli arti superiori o inferiori e disfunzione motoria ad esordio nell'età adulta. È considerata una variante della polineuropatia demielinizzante infiammatoria cronica."},"nl":{"name":"Syndroom van Lewis-Sumner","synonyms":["MADSAM","Multifocale verworven demyeliniserende sensorische en motorische neuropathie"],"definition":"Een zeldzame verworven demyeliniserende polyneuropathie, gekarakteriseerd door asymmetrische distale zwakheid van bovenste of onderste ledematen en motorische disfunctie met aanvang in de volwassenheid. Deze aandoening wordt beschouwd als een variant van chronische inflammatoire demyeliniserende polyneuropathie."},"pt":{"name":"Síndrome Lewis-Sumner"},"pl":{"name":"Zespół Lewisa i Sumnera","synonyms":["MADSAM","Wieloogniskowa nabyta demielinizująca neuropatia czuciowa i ruchowa"]},"cs":{"name":"Lewisův-Sumnerův syndrom","synonyms":["MADSAM","Multifokální získaná demyelinizační senzorická a motorická neuropatie","Lewis-Sumnerův syndrom"]},"uk":{"name":"Синдром Льюїса-Самнера","synonyms":["MADSAM","Мультифокальна набута демієлінізуюча сенсорна та моторна нейропатія"],"definition":"A rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of chronic inflammatory demyelinating polyneuropathy."},"zh":{"name":"Lewis-Sumner综合征","synonyms":["多灶性获得性脱髓鞘感觉和运动神经病"]},"tr":{"name":"Lewis-Sumner sendromu","synonyms":["MADSAM","Multifokal edinsel demiyelinizan duyusal ve motor nöropati"]}},"xrefs":[{"source":"ICD-10","code":"G61.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8C01.3","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"980657399"},{"source":"MONDO","code":"0018826","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1695985","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"13070","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10065580","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":2932,"name":"Chronic inflammatory demyelinating polyneuropathy","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.9,"area":"Europe","status":"Not yet validated","source":"19260065[PMID]"}],"phenotypes":null}