{"orpha":466677,"name":"Scorpion envenomation","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Scorpion envenomation is a rare intoxication caused by a scorpion sting which typically manifests with localized pain, edema, erythema, and paresthesias at the site of the sting and, when severe, progresses to produce systemic symptoms of variable severity that include respiratory difficulties, abnormal systemic blood pressure, cardiac arrhythmia, and a combination of parasympathetic (i.e. excessive salivation and lacrimation, diaphoresis, miosis, frequent urination, diarrhea, vomiting, priapism) and sympathetic (e.g. hyperthermia, hyperglycemia, mydriasis) manifestations. Neurological manifestations may also be associated, such as abnormal eye movements, blurred vision, agitation and restlessness, as well as muscle fasciculations and spasms. Signs and symptoms are highly variable and in most severe cases may lead to cardiogenic shock and pulmonary edema.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-466677/","orphanet_url":"https://www.orpha.net/en/disease/detail/466677","names":{"fr":{"name":"Envenimation suite à la morsure de scorpion","definition":"Une intoxication rare causée par la morsure d'un scorpion, qui se manifeste typiquement par une douleur localisée, un oedème, un érythème et une paresthésie au site de la morsure. Dans les cas sévères, elle évolue et se manifeste par des symptômes systémiques de sévérité variable, dont des troubles respiratoires, une pression sanguine systémique anormale, une arythmie cardiaque et une combinaison de manifestations parasympathiques (salivation et larmoiement excessifs, diaphorèse, myosis, besoin fréquent d'uriner, diarrhée, vomissements, priapisme) et sympathiques (ex. hyperthermie, hyperglycémie, mydriase). Des signes neurologiques peuvent aussi être associés, tels que des mouvements oculaires anormaux, une vision trouble, une agitation et une instabilité psychomotrice, ainsi que des fasciculations et des spasmes musculaires. Les signes et les symptômes sont très variables. Dans les cas les plus sévères, ils peuvent conduire à un choc cardiogénique et un oedème pulmonaire."},"de":{"name":"Vergiftung durch Skorpionstiche"},"es":{"name":"Envenenamiento por escorpión","definition":"Es una intoxicación poco frecuente causada por la picadura de escorpión, que típicamente se manifiesta con dolor localizado, edema, eritema y parestesias en el sitio de la picadura. Cuando es grave, progresa para producir síntomas sistémicos de intensidad variable que incluyen dificultades respiratorias, presión arterial alterada, arritmia cardíaca y una combinación de manifestaciones parasimpáticas (es decir, salivación y lagrimeo excesivos, diaforesis, miosis, micción frecuente, diarrea, vómitos, priapismo) y manifestaciones simpáticas (p. ej., hipertermia, hiperglucemia, midriasis). También pueden estar asociadas ciertas manifestaciones neurológicas, tales como movimientos oculares anómalos, visión borrosa, agitación e inquietud, así como fasciculaciones musculares y espasmos. Los signos y síntomas son muy variables y, en la mayoría de casos graves, pueden provocar shock cardiogénico y edema pulmonar."},"it":{"name":"Avvelenamento da puntura di scorpione","definition":"L'avvelenamento da puntura di scorpione è un'intossicazione rara, che di solito si manifesta con dolore, edema ed eritema localizzati, e con parestesie attorno al sito della puntura. Nei casi più gravi, si osservano sintomi sistemici di gravità variabile, che comprendono le difficoltà respiratorie, le anomalie della pressione arteriosa, l'aritmia cardiaca e un insieme di sintomi parasimpatici (salivazione e lacrimazione eccessive, diaforesi, miosi, minzione frequente, diarrea, vomito, priapismo) e simpatici (ipertermia, iperglicemia, midriasi). Possono associarsi sintomi neurologici, come le anomalie dei movimenti oculari, l'annebbiamento della vista, l'agitazione, l'irrequietezza, le fascicolazioni e gli spasmi muscolari. I segni clinici sono molto variabili e, nei casi più gravi, possono esitare nello shock cardiogeno e nell'edema polmonare."},"nl":{"name":"Vergiftiging door schorpioenensteek","definition":"Vergiftiging als gevolg van een schorpioenensteek is een zeldzame intoxicatie die veroorzaakt wordt door de steek van een schorpioen, die zich doorgaans manifesteert met gelokaliseerde pijn, oedeem, erytheem en paresthesie op de plaats van de steek, en die, indien ernstig, evolueert naar systemische symptomen met variabele gradaties van ernst waaronder ademhalingsproblemen, abnormale systemische bloeddruk, hartritmestoornissen, en een combinatie van parasympathische (i.e. overmatige speeksel- en traanproductie, diaforese, miosis, frequent urineren, diarree, braken, priapisme) en sympathische (e.g. hyperthermie, hyperglykemie, pupildilatatie) manifestaties. Neurologische manifestaties kunnen ook geassocieerd zijn, zoals abnormale oogbewegingen, wazig zicht, agitatie en rusteloosheid, alsook spierfasciculaties en -spasmen. Tekenen en symptomen zijn zeer variabel en kunnen in de ergste gevallen leiden tot cardiogene shock en longoedeem."},"pt":{"name":"Envenenamento por escorpião"},"pl":{"name":"Zatrucie jadem skorpiona","definition":"*Zatrucie jadem skorpiona jest rzadkim zatruciem spowodowanym przez użądlenie skorpiona, które zwykle objawia się miejscowym bólem, obrzękiem, rumieniem i parestezjami w miejscu użądlenia, zaś w formie ciężkiej wywołuje ogólnoustrojowe objawy o różnym nasileniu, w tym trudności w oddychaniu, nieprawidłowe ciśnienie krwi, arytmię serca oraz różnorodne objawy z układu przywspółczulnego (tj. nadmierne wydzielanie śliny i łzawienie, obfite pocenie się, zwężenie źrenic, częste oddawanie moczu, biegunkę, wymioty, priapizm – długotrwały wzwód prącia) oraz współczulnego (np. hipertermia, hiperglikemia, rozszerzenie źrenic). Mogą również wystąpić objawy neurologiczne, takie jak nieprawidłowe ruchy gałek ocznych, niewyraźne widzenie, pobudzenie i niepokój, a także fascykulacje mięśni (skurcze grup włókienek mięśniowych) i skurcze. Objawy są bardzo zmienne, a w najpoważniejszych przypadkach mogą prowadzić do wstrząsu kardiogennego i obrzęku płuc."},"cs":{"name":"Bodnutí štírem"},"uk":{"name":"Отруєння скорпіона","definition":"Scorpion envenomation is a rare intoxication caused by a scorpion sting which typically manifests with localized pain, edema, erythema, and paresthesias at the site of the sting and, when severe, progresses to produce systemic symptoms of variable severity that include respiratory difficulties, abnormal systemic blood pressure, cardiac arrhythmia, and a combination of parasympathetic (i.e. excessive salivation and lacrimation, diaphoresis, miosis, frequent urination, diarrhea, vomiting, priapism) and sympathetic (e.g. hyperthermia, hyperglycemia, mydriasis) manifestations. Neurological manifestations may also be associated, such as abnormal eye movements, blurred vision, agitation and restlessness, as well as muscle fasciculations and spasms. Signs and symptoms are highly variable and in most severe cases may lead to cardiogenic shock and pulmonary edema."},"zh":{"name":"蝎毒","definition":"蝎子毒液中毒是一种罕见的由蝎子蜇伤引起的中毒，一般表现为蜇伤部位的局部疼痛、水肿、红斑和麻痹，严重时可进展为产生多种全身症状，包括呼吸困难、全身血压异常、心律失常，并合并有副交感神经（如唾液分泌过多和流涎、尿失禁、尿频、腹泻、呕吐、遗尿症）和交感神经（如高热、高血糖、尿毒症）的综合表现。还可能伴有神经系统表现，如眼球运动异常、视力模糊、烦躁不安，以及肌肉肌束震颤和痉挛。症状和体征变化很大，最严重时可导致心源性休克和肺水肿。"},"tr":{"name":"Akrep zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T63.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"311621356"},{"source":"MONDO","code":"0018755","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D065008","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0238417","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_27912864[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-05","source":"25075837[PMID]_26676487[PMID]","terms":[{"hpo":"HP:0000969","label":"Edema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012531","label":"Pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031546","label":"Cardiac conduction abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000616","label":"Miosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000711","label":"Restlessness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031416","label":"Abnormal nasal mucus secretion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004360","label":"Abnormality of acid-base homeostasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001735","label":"Acute pancreatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030149","label":"Cardiogenic shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031956","label":"Elevated circulating aspartate aminotransferase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003781","label":"Excessive salivation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003076","label":"Glycosuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003074","label":"Hyperglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002900","label":"Hypokalemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031185","label":"Increased circulating NT-proBNP concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032232","label":"Increased circulating creatine kinase MB isoform","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0410173","label":"Increased circulating troponin I concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005967","label":"Mixed respiratory and metabolic acidosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200023","label":"Priapism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025072","label":"Prominent U wave","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001950","label":"Respiratory alkalosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012250","label":"ST segment depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010872","label":"T-wave inversion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012547","label":"Abnormal involuntary eye movements","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001251","label":"Ataxia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011710","label":"Bundle branch block","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100660","label":"Dyskinesia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010828","label":"Hemifacial spasm","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002487","label":"Hyperkinetic movements","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001347","label":"Hyperreflexia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002919","label":"Ketonuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001336","label":"Myoclonus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006682","label":"Ventricular extrasystoles","frequency":"Very rare (<4-1%)","criteria":null}]}}