{"orpha":457095,"name":"Actinomycosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare bacterial infectious disease characterized by a chronic granulomatous infection by <i>Actinomyces</i> species which are commensals in the human gastrointestinal and urogenital tract and oropharynx. Corresponding to the affected site, the disease presents as cervicofacial, respiratory tract, genitourinary tract, digestive tract, central nervous system, or cutaneous actinomycosis and leads to the formation of abscesses and fistulae in the respective region.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-457095/","orphanet_url":"https://www.orpha.net/en/disease/detail/457095","names":{"fr":{"name":"Actinomycose","synonyms":["Actinobactériose"],"definition":"Maladie infectieuse bactérienne rare caractérisée par une infection granulomateuse chronique par des espèces <i>Actinomyces</i> qui sont des commensaux du tractus gastro-intestinal, de l'urogénital humain et de l'oropharynx. En fonction du site affecté, la maladie se présente sous la forme d'une actinomycose cervico-faciale, de l'appareil respiratoire, de l'appareil génito-urinaire, de l'appareil digestif, du système nerveux central ou cutanée, et cause la formation d'abcès et de fistules dans la région de l'organisme concernée."},"de":{"name":"Aktinomykose","definition":"Eine seltene bakterielle Infektionskrankheit, die durch eine chronische granulomatöse Infektion durch <i>Actinomyces</i>-Arten gekennzeichnet ist, die Kommensalen im menschlichen Magen-Darm-Trakt, Urogenitaltrakt und Oropharynx sind. Je nach betroffener Stelle präsentiert sich die Krankheit als zervikofaziale, respiratorische, urogenitale, verdauungsfördernde, zentralnervöse oder kutane Aktinomykose und führt zur Bildung von Abszessen und Fisteln in der jeweiligen Region."},"es":{"name":"Actinomicosis","definition":"Es una enfermedad infecciosa bacteriana poco frecuente caracterizada por una infección granulomatosa crónica por especies de <i>Actinomyces</i>, microorganismos comensales del tracto gastrointestinal y urogenital así como de la orofaringe de los humanos. Dependiendo de la localización, la enfermedad se presenta como una infección cérvico-facial, del tracto respiratorio, genitourinario o digestivo, del sistema nervioso central o como una actinomicosis cutánea conducente a la formación de abscesos y fístulas en la región afectada."},"it":{"name":"Actinomicosi","definition":"Si tratta di un'infezione batterica rara, caratterizzata da un'infezione granulomatosa cronica causata dalla specie <i>Actinomyces</i>, composta da commensali del tratto gastrointestinale e urogenitale, e dell'orofaringe dell'uomo. A seconda della localizzazione, la malattia esordisce con actinomicosi cervico-facciale, delle vie respiratorie, del tratto urogenitale, del tratto digestivo, del sistema nervoso centrale o della cute, ed esita nella formazione di ascessi e fistole nella zona interessata."},"nl":{"name":"Actinomycose","synonyms":["Straalschimmelziekte"],"definition":"Een zeldzame, bacteriële infectieuze aandoening, gekarakteriseerd door een chronische granulomateuze infectie met soorten van het geslacht <i>Actinomyces</i>, die commensalen zijn in het gastro-intestinale en urogenitale stelsel en de orofarynx van mensen. Afhankelijk van het aangetaste gebied presenteert de ziekte zich als cervicofaciale actinomycose, actinomycose van ademhalingsstelsel, urogenitaal stelsel, spijsverteringsstelsel, centraal zenuwstelsel, of cutane actinomycose, en leidt tot vorming van abcessen en fistels in de overeenkomstige gebieden."},"pt":{"name":"Actinomicose"},"pl":{"name":"Aktynomikoza"},"cs":{"name":"Aktinomykóza"},"uk":{"name":"Актиномікоз","definition":"A rare bacterial infectious disease characterized by a chronic granulomatous infection by <i>Actinomyces</i> species which are commensals in the human gastrointestinal and urogenital tract and oropharynx. Corresponding to the affected site, the disease presents as cervicofacial, respiratory tract, genitourinary tract, digestive tract, central nervous system, or cutaneous actinomycosis and leads to the formation of abscesses and fistulae in the respective region."},"zh":{"name":"放线菌病","definition":"一种罕见的细菌性传染病，其特征是由人类胃肠道、泌尿生殖道和口咽部共生的放线菌属引起的慢性肉芽肿感染。对应于受累部位，本病表现为颈面部、呼吸道、泌尿生殖道、消化道、中枢神经系统或皮肤放线菌病，并在相应部位形成脓肿和瘘管。"},"tr":{"name":"Aktinomikoz"}},"xrefs":[{"source":"ICD-10","code":"A42.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A42.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A42.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A42.7","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"A42.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C10","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1697630330"},{"source":"ICD-11","code":"1C10.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"452367246"},{"source":"ICD-11","code":"1C10.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"2143116824"},{"source":"ICD-11","code":"1C10.2","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"185601767"},{"source":"ICD-11","code":"1C10.3","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"413315344"},{"source":"ICD-11","code":"1C10.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0005631","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000196","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0001261","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5728","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10000620","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_18078685[PMID]"}],"phenotypes":null}