{"orpha":454836,"name":"Avian influenza","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, infectious disease characterized by variable severity and outcome, ranging from mild upper respiratory tract infection with fever and cough, to influenza-like illness with rapid progression to severe pneumonia, sepsis with shock, acute respiratory distress syndrome and even death. Additional manifestations may include conjunctivitis, nausea, abdominal pain, diarrhea, vomiting, multiple organ dysfunction, and encephalopathy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-454836/","orphanet_url":"https://www.orpha.net/en/disease/detail/454836","names":{"fr":{"name":"Grippe aviaire","definition":"Maladie infectieuse rare caractérisée par une sévérité et une issue variables, allant d'une infection légère des voies respiratoires supérieures avec fièvre et toux à un syndrome pseudo-grippal progressant rapidement vers une pneumonie sévère, une septicémie avec choc, un syndrome de détresse respiratoire aiguë, voire même le décès du patient. Les autres manifestations peuvent inclure une conjonctivite, des nausées, des douleurs abdominales, des diarrhées, des vomissements, une défaillance multiviscérale et une encéphalopathie."},"de":{"name":"Vogelgrippe","synonyms":["Aviäre Influenza"],"definition":"Eine seltene Infektionskrankheit mit unterschiedlichem Schweregrad und Ausgang, die von einer leichten Infektion der oberen Atemwege mit Fieber und Husten bis hin zu einer grippeähnlichen Erkrankung mit raschem Fortschreiten zu schwerer Lungenentzündung, Sepsis mit Schock, akutem Atemnotsyndrom und sogar Tod reicht. Weitere Symptome können Konjunktivitis, Übelkeit, Bauchschmerzen, Durchfall, Erbrechen, Funktionsstörungen mehrerer Organe und Enzephalopathie sein."},"es":{"name":"Gripe aviar","synonyms":["Gripe aviaria"],"definition":"Es una enfermedad infecciosa poco frecuente caracterizada por una gravedad y un pronóstico variables que van desde una infección leve del tracto respiratorio superior con fiebre y tos, hasta una enfermedad similar a la gripe con una rápida progresión a neumonía grave, choque séptico, síndrome de distrés respiratorio agudo e incluso muerte. Otras manifestaciones adicionales pueden incluir conjuntivitis, náusea, dolor abdominal, diarrea, vómitos, disfunción multiorgánica y encefalopatía."},"it":{"name":"Influenza aviaria","synonyms":["Influenza da H5N1"],"definition":"È una malattia infettiva rara, caratterizzata da gravità ed esiti variabili, che comprende una lieve infezione delle vie aeree superiori con febbre e tosse, fino ad una malattia simil-influenzale che progredisce rapidamente nella polmonite, nello shock settico, nella sindrome da distress respiratorio acuto e nella morte. Può associarsi a congiuntivite, nausea, dolore addominale, diarrea, vomito, disfunzione multiorgano ed encefalopatia."},"nl":{"name":"Vogelgriep","synonyms":["Aviaire influenza"],"definition":"Een zeldzame infectieziekte gekarakteriseerd door variabele ernst en uitkomst, gaande van milde infectie van de bovenste luchtwegen met koorts en hoest, tot griepachtige ziekte met snelle progressie tot ernstige pneumonie, sepsis met shock, acute ademnoodsyndroom en zelfs overlijden. Mogelijke bijkomende manifestaties zijn onder meer bindvliesontsteking, misselijkheid, buikpijn, diarree, braken, disfunctie van meerdere organen, en encefalopathie."},"pt":{"name":"Gripe aviária"},"pl":{"name":"Ptasia grypa","synonyms":["Grypa H5N1"]},"cs":{"name":"Ptačí chřipka"},"uk":{"name":"Пташиний грип","definition":"A rare, infectious disease characterized by variable severity and outcome, ranging from mild upper respiratory tract infection with fever and cough, to influenza-like illness with rapid progression to severe pneumonia, sepsis with shock, acute respiratory distress syndrome and even death. Additional manifestations may include conjunctivitis, nausea, abdominal pain, diarrhea, vomiting, multiple organ dysfunction, and encephalopathy."},"zh":{"name":"禽流感","definition":"一种罕见的传染病，其特征和严重程度不同，从轻度发烧和咳嗽引起的上呼吸道感染，到快速发展的严重肺炎，败血症伴休克，急性呼吸窘迫综合征甚至死亡的流感样疾病。其他临床表型包括结膜炎，恶心，腹痛，腹泻，呕吐，多器官功能障碍和脑病。"},"tr":{"name":"Kuş gribi"}},"xrefs":[{"source":"ICD-10","code":"J09","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1E31","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1188232632"},{"source":"MONDO","code":"0018695","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D005585","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0016627","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10064097","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]},{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":826.0,"area":"Worldwide","status":"Validated","source":"World Health Organization 2015[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET_World Health Organization 2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-31","source":"28159162[PMID]_31668198[PMID]","terms":[{"hpo":"HP:0012735","label":"Cough","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025179","label":"Ground-glass opacification on pulmonary HRCT","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001888","label":"Lymphopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031246","label":"Nonproductive cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002113","label":"Pulmonary infiltrates","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031245","label":"Productive cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003073","label":"Hypoalbuminemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012486","label":"Myelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Very rare (<4-1%)","criteria":null}]}}